Showing papers in "Natural Product Reports in 2009"

TL;DR: This review summarizes the chemistry, biosynthesis and occurrence of the compounds involved, namely the C6-C3-C6 flavonoids-anthocyanins, dihydrochalcones, Flavan-3-ols, flavanones, flavones, Flavonols and isoflavones, and the mechanisms underlying these processes are discussed.

TL;DR: Trends in the secondary metabolomes of natural product-rich actinomycetes are highlighted in this review article, which contains 199 references.

TL;DR: This review describes secondary metabolites that have been shown to be synthesized by symbiotic bacteria, or for which this possibility has been discussed, and includes 365 references.

TL;DR: An overview of the astonishing metabolic capacity of the Pseudomonads is provided, the knowledge of secondary metabolite biosynthesis in this group of organisms is summarized, and the biological significance of these compounds to the diverse life styles exhibited by PseUDomonas spp.

TL;DR: This review focuses on the advances in the last 15 years, and cites 149 references, in understanding blue flower coloration since the comprehensive review by Goto and Kondo in 1991.

TL;DR: From January 1995 to the end of 2008, more than 400 new naturally occurring stilbenes were isolated and identified, and this review focuses on their structural diversity, distribution, and bioactivity.

TL;DR: The heparin contamination crisis, its resolution, and the lessons learned are reviewed, with the conclusion that safer and better-regulated processes are needed for heparIn production.

TL;DR: The aim of this review is to cover the recent advances in phytochemical antibacterial activities and their mode of action, as well as to indicate current developments in their control of MDR bacteria and biofilms.

TL;DR: This review deals with the isolation and structure elucidation of meroterpenoids from higher and lower fungi, and discusses biosynthetic studies and biological activities as appropriate.

TL;DR: This review covers the biosynthesis of extender units that are utilized for the assembly of polyketides by polyketide synthases.

TL;DR: Ecteinascidins are marine natural products consisting of two or three linked tetrahydroisoquinoline subunits and an active carbinolamine functional group that make them attractive candidates for development as anticancer agents.

TL;DR: The major structural and biosynthetic categories of ribosomally synthesized bacterial natural products and, where applicable, compare them to their homologs from nonribosomal biosynthesis are summarized.

TL;DR: The mangrove flora is a diverse group of salt-tolerant plants growing in tropical and subtropical intertidal estuarine zones and the molecular phylogeny and chemotaxonomy of trueMangrove plants is discussed.

TL;DR: This comprehensive review summarizes all the research into the isolation and structure elucidation of the Daphniphyllum alkaloids reported since investigations began in 1966.

TL;DR: This review covers the source, chemistry and bioactivities of natural lignans, and highlights the total syntheses of some lignan motifs and asymmetric synthese of their motifs.

TL;DR: This review highlights the role of total synthesis in the structural revision of natural products and its importance in the development of new drugs and medical products.

TL;DR: Recent breakthrough achievements in both X-ray and NMR spectroscopic studies are reviewed that illuminate the architecture of NRPS PCP domains, PCP-containing didomain-fragments and of a full termination module (C-A-PCP-TE).

TL;DR: This review, containing over 276 references, covers the progress made in the chemistry and bioactivity of boswellic acids, and the phytochemistry and chemical modifications, including mechanism of action, are discussed.

TL;DR: The antitumor and anti-HIV activities of naturally occurring triterpenoids, including the lupane, ursane, oleanane, lanostane, dammarane, and miscellaneous scaffolds are reviewed.

TL;DR: This review highlights novel molecules isolated from microorganisms that either tolerate or favour extreme growth conditions.

TL;DR: A brief background to the discovery of conotoxins is given and their sequences, biological activities, and applications in drug design are described.

TL;DR: This review summarises how molecular structure influences the balance between the immunomodulatory and antimicrobial functions of LL-37.

TL;DR: Several examples of new biosynthetic chemistry discovered in the course of investigating gene clusters that direct the biosynthesis of known natural products are highlighted.

TL;DR: This review describes 602 new compounds isolated from gorgonian corals, with a focus on the structures of new compounds as well as their biological activity.

TL;DR: Metagenomic analysis provides an alternative method to directly access the uncultivated genome for natural products research and for the discovery of novel, bioactive substances.

TL;DR: Antitumor compounds produced by actinomycetes and novel derivatives generated by combinatorial biosynthesis are reviewed and a description of the strategies used for the generation of the novel derivatives and the activities of these compounds against tumor cell lines is described.

TL;DR: An overview of current methods for the chemical synthesis of NDP- and NMP-sugars, including recently developed protocols for the direct chemical manipulation of unprotected sugar-nucleotides are presented.

TL;DR: Three different imaging mass spectrometry approaches, MALDI, DESI and SIMS and their recent applications in the analysis of natural products are described.

TL;DR: This review describes the recent developments in functional genomics efforts targeting plant secondary metabolism and indicates substantial progress has been made in Arabidopsis thaliana because of its publicly-available biological materials and genome-related information.

TL;DR: This review focuses on the impact of genomics on the evaluation and exploitation of myxobacteria and the exploitation of their biosynthetic potential.