Showing papers in "Natural Product Reports in 2012"

TL;DR: The aim of this article is to review the advances in in vitro and in vivo studies on the potential chemotherapeutic value of phytochemical products and plant extracts as RMAs to restore the efficacy of antibiotics against resistant pathogenic bacteria.

TL;DR: This review focuses on the distribution of stilbenes and 2-arylbenzofuran derivatives in the plant kingdom, the chemical structure of stILbenes in the Vitaceae family and their taxonomic implication.

TL;DR: The complexity of terpenoid natural products has drawn significant interest, and while this has certainly led to some insights into the enzymatic structure-function relationships underlying the elongation and simpler cyclization reactions, the understanding of the more complex cyclization and/or rearrangement reactions remains limited.

TL;DR: This review highlights not only what has been revealed about the structures and activities of each of the domains of type I polyketide synthases but also the mysteries that remain to be solved.

TL;DR: The main focus of this article is on new synthetic approaches and biosynthetic investigations, most of which were published between 1997 and 2010, but go beyond, e.g. for some biosyntheses all the way back to the 1980s, to provide the necessary context of information.

TL;DR: This review focuses on the recent discoveries and breakthroughs in the structural elucidation, molecular mechanism, and chemical biology underlying the discrete domains within NRPSs.

TL;DR: This review will focus on the structural modifications, structure-activity relationships, pharmacology, and clinical development of triptolide in the last forty years.

TL;DR: This review studies the impact of whole genome sequencing on Aspergillus secondary metabolite research and disclosed the surprising finding that there are many more secondary metabolites biosynthetic pathways than laboratory research had suggested.

TL;DR: Engineering microbial-derived P450 enzymes to accommodate alternative substrates and add new functions continues to be an important near- and long-term practical goal driving the structural characterization of these molecules.

TL;DR: In this review, recent discoveries of anti-diabetic compounds have been summarized according to their chemical structures and mechanisms of action.

TL;DR: A comprehensive compilation of electrophilic natural products from all major chemical classes together with their biological targets, with special emphasis on the elucidation of their respective biological targets via activity-based protein profiling.

TL;DR: It is shown how a widespread protein fold evolved to accommodate chemically diverse methyl acceptors and to catalyse disparate mechanisms suited to the physiochemical properties of the target substrates, suggesting that NPMTs may serve as starting points for generating new biocatalysts.

TL;DR: This review describes the structure and function of all known lasso peptides (as of mid-2012) and covers the current knowledge about the biosynthesis of those molecules.

TL;DR: A snapshot of the important work done on the lysobacterial natural products is provided to provide useful information for future biosynthetic engineering of novel antibiotics in Lysobacter.

TL;DR: A phytochemical update will be provided and the total synthesis of alkaloids and terpenoids will be discussed in detail, as Homoharringtonine is active against some orphan leukaemia and is nowadays approaching marketability.

TL;DR: Recent advances in the discovery, synthesis, target identification, structure-activity relationships, HDAC8-largazole thiol crystal structure, and biological studies are surveyed, including in vivo anticancer and osteogenic activities.

TL;DR: This review covers the structural and biochemical characterization of carrier proteins, as well as assessing their interactions with different ligands, and other synthase components.

TL;DR: This work addresses the latest developments in theoretical and experimental research on properties of NA that are and will be driving anti-influenza drug development now and in the near future.

TL;DR: This review covers the literature on the chemically mediated ecology of cyanobacteria, including ultraviolet radiation protection, feeding-deterrence, allelopathy, resource competition, and signalling.

TL;DR: Recent research into the structure and function of sesquiterpene synthases and the mechanisms of the reactions that they catalyse are reviewed to suggest that these fascinating enzymes play multifaceted active roles in what are arguably the most complex biosynthetic reactions.

TL;DR: This review covers the emerging biosynthetic role of crotonyl-CoA carboxylase/reductase (CCR) homologs in extending the structural and functional diversity of polyketide natural products.

TL;DR: This review includes a comprehensive description of the state of the art for CDPS-dependent pathways, and highlights the ways in which this knowledge could be used to increase the diversity of natural DKPs by pathway engineering.

TL;DR: This review covers the literature of prenylated quinone, hydroquinone and naphthoquinone marine natural products with reported cytotoxic and/or antioxidant properties and recent biosynthetic studies of selected compounds are discussed.

TL;DR: The chemical nature and signaling pathways of natural products released by microorganisms, Herbivores, and plants during pathogenic infections, herbivory, symbioses and allelopathic interactions are reviewed.

TL;DR: This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects.

TL;DR: Progress in identification of natural products that bind to the major groove of DNA is summarized and recent reports of non-covalent major groove binding with carbohydrates, aminoglycosides in particular, have revealed them as promising leads for DNA major groovebinding probes or drugs.

TL;DR: The challenges synthetic chemists are facing during the synthesis of this small, but structurally and biologically fascinating class of natural products are described, concentrating on the representatives exhibiting configurational stability.

TL;DR: This review covers the biosynthesis of AHBA-derived natural products from a molecular genetics, chemical, and biochemical perspectives, and 174 references are cited.

TL;DR: The present review discusses both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti-cancer activities of these compounds.

TL;DR: This review summarizes the structural studies of bacterial enzymes involved in biosynthesis of novel sugar nucleotides and serves as a starting point for engineering variant enzymes to facilitate to production of differentially-glycosylated natural products.