Showing papers in "Natural Product Reports in 2015"

TL;DR: This review highlights the broad range of science that has arisen from the synthesis of coumarin-linked and fused heterocycle derivatives and their synthesis and biological activity.

TL;DR: The ability of natural receptors to possess differential binding between atropisomers is an important factor when considering active and inactive atrop isomeric drugs, and has required the development of new techniques for atropselective synthesis of desired targets.

TL;DR: It is argued that a network pharmacology approach would enable an effective mapping of the yet unexplored target space of natural products, hence providing a systematic means to extend the druggable space of proteins implicated in various complex diseases.

TL;DR: The described protective symbioses between animals and bacteria, fungi, and dinoflagellates are reviewed to derive general patterns on the chemistry, ecology, and evolution of such associations.

TL;DR: The mechanisms of action of ginsenosides and their metabolites, which can modulate signaling pathways associated with inflammation, oxidative stress, angiogenesis, metastasis, and stem/progenitor-like properties of cancer cells are reviewed.

TL;DR: Dereplication has become a hot topic presenting a huge publication boom since 2012, blending multidisciplinary fields in new ways that provide important conceptual and/or methodological advances, opening up pioneering research prospects in this field.

TL;DR: A substantial review of recent technical advances in mass spectrometry imaging, nuclear magnetic resonance imaging, integrated LC-MS-SPE-NMR for metabolite identifications, and X-ray crystallography of microgram quantities for structural determinations is provided.

TL;DR: The biological properties of natural abietane-type diterpenoids with an aromatic C ring are reviewed and an overview of the synthetic studies of this group of abietanes, including dehydroabietic acid, callitrisic acid and ferruginol is presented.

TL;DR: This review examines interspecies interactions, and the natural products involved, as they have been presented in literature stemming from four disciplines: soil science, interspecies microbiology, ecology, and evolutionary biology, and considers how these interactions fit into accepted paradigms of signaling, cueing, and coercion.

TL;DR: This review focuses on the different types of methods that have been successfully used in the total synthesis of natural products, placing emphasis on the diastereoselective preparation of vicinal quaternary carbon centers and the subsequent total syntheses.

TL;DR: A critical review of the state-of-the-art in broad-spectrum antiviral drug discovery discusses putative targets and treatment strategies, with particular focus on natural products as promising starting points for antiviral lead development.

TL;DR: This work seeks to give an overview of all reliably-described xanthone dimers, their structures, occurrence, and the bioactivities established to date.

TL;DR: An overview of the initial discovery of the marine actinomycete genus Salinispora and its development as a model for natural product research illustrates the extraordinary biosynthetic diversity that can emanate from a narrowly defined genus and supports future efforts to explore marine taxa in the search for novel natural products.

TL;DR: This review investigates the use of complex ester fragment couplings within natural product total synthesis campaigns and presents and discusses a collection of successful examples from the literature.

TL;DR: More than 250 new triterpenoids are reviewed and their structures, classifications, biogenetic pathways, syntheses, and bioactivities are described.

TL;DR: The isolation and structural and biological characterization of phytotoxins produced by pathogenic fungi for weeds, including parasitic plants, are described and structure activity relationships and mode of action studies are reported to elucidate the herbicide potential of these promising fungal metabolites.

TL;DR: This review summarizes recent work on fatty acid-derived compounds (fatty acid alkyl esters, fatty alcohols, medium- and short-chain methyl ketones, alkanes, α-olefins, and long-chain internal alkenes) and isoprenoids, including hemiterpenes, monoterpenes and sesquiterpene, including farnesene and bisabolene.

TL;DR: The background and implications of the discovery of artemisinin, along with personal viewpoints toward the affordability of modern medicines from natural products are provided.

TL;DR: This review will focus on compounds for which the direct targets have been deciphered or which were found to target a novel pathway, and link them to disease states where target modulation may be beneficial.

TL;DR: The total syntheses of 33 complex natural O-glycosides, such as the glycosides of macrocyclic lactones/lactams, enediynes, angucyclines, and anthracyclines, are highlighted, with a major focus being placed on the O- glycosylation reactions which connect the saccharides and the aglycones.

TL;DR: Et-743 stands out as the most potent antitumor antibiotics that it is recently approved for treatment of a number of soft tissue sarcomas.

TL;DR: This review covers conformational and configurational assignments in natural product molecules using chiroptical spectroscopy reported over the last 15 years with special attention to vibrational optical activity methods associated with quantum mechanical calculations.

TL;DR: This review intends to present examples of the various chemical interactions of fungi with other fungi, plants, bacteria and animals and to give an overview of the current knowledge of fungal chemical ecology.

TL;DR: This review is mainly focused on the synthesis of various types of nitrogen and occasionally sulfur-containing heterocyclic triterpenoids for their potential use as future drugs in medicine and in addition discusses their overall biological activities.

TL;DR: This highlight article will focus on recent studies of the mechanisms utilized by indole prenyltransferases and suggests that in some cases prenolation may first occur at the nucleophilic C-3 position, and subsequent rearrangements then generate the final product.

TL;DR: This review comprehensively highlights successful applications of metabolomics in chemical ecology and discusses existing limitations of these novel techniques and outlines the potential of large metabolomics initiatives for model organisms in the field of chemical ecology.

TL;DR: Structures and properties of phenylglycine containing natural products as well as the biosynthetic origin and incorporation of phenolglycines are discussed.

TL;DR: This highlight provides an overview of recent progress towards elucidating the structure, biosynthesis, and mode of action of colibactin, a genotoxic secondary metabolite synthesized by human gut bacteria.

TL;DR: The current knowledge on lactone semiochemicals from insects, vertebrates and bacteria will be described, concentrating on the structure, chemistry, function, biosynthesis and synthesis of these compounds.

TL;DR: This review covers the isolation and chemistry of diterpenoids from terrestrial as opposed to marine sources and includes labdanes, clerodanes, abietanes, pimaranes, kauranes, cembranes and their cyclization products.