Showing papers in "Natural Product Research in 2021"

TL;DR: Mechanistic studies indicated that 3 induces apoptotic cell death, and the structure of the new compound, pretrichodermamide G, was established on the basis of spectroscopic data, including 1D/2D NMR and HRESIMS.

TL;DR: Overall the greatest effect was for the fish treated with medium dose of astaxanthin (100 mg.kg-1), under the artificial light conditions of rearing, which indicated the important effects of all three factors (light source, dosage and carotenoids type).

TL;DR: Biological activities of J. regia extract may be due to its high flavonoid and phenolic contents, and they deserve further scientific investigations.

TL;DR: The bark and leaf oils showed a remarkable inhibitory effect against all tested bacterial strains with minimum inhibitory concentration (MIC) range of 25 to 300 µg/mL, while the bark oil was active against Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 10145 only.

TL;DR: A review of the studies conducted to date about this issue and try to understand whether the use of nutraceuticals as a supplementary therapy to COVID-19 may be a valid and viable avenue is presented in this paper.

TL;DR: Five flavonoids from a traditional Chinese herb, Artemisia rupestris L., with synergistic antibacterial effects against multidrug-resistant Staphylococcus aureus are discovered with synergy effects.

TL;DR: The essential oil from M. spicata showed a more preeminent effect against Cryptococcus neoformans and the dermatophytes Trichophyton rubrum and T. verrucosum, and both oils were very effective in inhibiting C. albicans germ tube formation, at doses well below their MIC.

TL;DR: The results indicated that the EtOAc extract exhibited the best antioxidant potential among these four extracts in all three antioxidant bioassay platforms.

TL;DR: During drought stress, transcription factors and related pathways for biosynthesis of phenolics, flavonoids, anthocyanins as well as for stress jasmonate and abscisic acid stress hormones are activated.

TL;DR: Both TPC and TFC were positively correlated with radical scavenging and cytotoxic activities and all medicinal plants were considered inactive, in particular L. barbarum and G. uralensis.

TL;DR: In this article, the chemical compositions of the essential oils from roots, stems, leaves and fruits of Foeniculum vulgare subsp. piperitum collected in Sicily were evaluated by GC and GC-MS.

TL;DR: Diverse biological activity of meleagrin (1) was investigated and compound 1 pronounced potent cytotoxicity against the human cervix carcinoma cell line KB-3-1 and its multidrug resistant sub-clone KB-V1 of IC50 3.

TL;DR: The research showed results related to the effects of Maca on the quality and quantity of the semen, sexual behaviour and disorders of the male genital tract, and further research is needed to clarify the mechanisms of action of MacA.

TL;DR: The apple juice supplemented solid rice media led to significant changes in the secondary metabolism of the fungus, C. rosea B5-2, and induced the production of four new compounds, (-)-dihydrovertinolide (2), which exhibited phytotoxicity against lettuce seedlings at a concentration of 50 mg L−1.

TL;DR: Fifteen known phenolic compounds were isolated and identified from the roots and rhizomes of Glycyrrhiza uralensis, including ten flavonoids, four coumarins, and two benzofurans compounds, including the first time that their PD-1/PD-L1 inhibition activities were reported.

TL;DR: LBT was found to weakly inhibit XO activity via a mixed type mechanism and the impact of 1-week oral LBT treatment on serumXO activity in vivo is limited in hyperuricemic mice, however, oral L BT at 50 mg/kg significantly reduced hepatic XOActivity in vivo.

TL;DR: P. ferulacea essential oil chemical composition and the antioxidant, anti-acetylcholinesterase (AChE) and cytotoxic activities have been studied and a new chemotype is identified and good biological results are reported.

TL;DR: In this paper, P. longifolia leaves extract alleviating effect was assessed in nephritic-induced rats by whole body shot dose of γ-radiation, which significantly ameliorated all elevated biomarker levels.

TL;DR: Two new flavonoids were isolated from the leaves of Rhododendron dauricum and evaluated for their inhibitory effects on the production of tumour necrosis factor (TNF)-α in LPS-stimulated RAW 264 cells.

TL;DR: The potent activities of 16α-hydroxycleroda-3,13-dien-16,15-olide-3-al suggest its potential application as an anti-histaminic and antimicrobial agent.

TL;DR: Chemical investigation of endophytic fungus Phyllosticta capitalensis, isolated from the hypocotyls of the Chinese mangrove Bruguiera sexangula led to the isolation of eight known secondary metabolites, the first report of these compounds being isolated from this fungal species.

TL;DR: An unprecedented saponin is being reported herein together with five known compounds from the methanol extract of the roots of Albizia adianthifolia together with considerable inhibition of the new saponIn against the studied bacteria with MIC values ranging from 16 to 128 μg/mL.

TL;DR: The pulps were found to be the best source of dietary fibre, based on the amount and on the best insoluble/soluble ratio, and the total, the insoluble and the soluble dietary fibre (TDF, IDF and SDF respectively).

TL;DR: Two new fusicoccane diterpene and pinophicin A, and a new polyene, pinophol A, were isolated from the plant endophytic fungus Talaromyces pinophilus obtained from the aerial parts of Salvia miltiorrhiza.

TL;DR: Results show that Morosil®, a standardised extract of Moro blood oranges exerts antioxidant and anti-adipogenic activities during adipocyte differentiation of 3T3-L1 pre- adipocytes.

TL;DR: Eight antiviral compounds identified showed inhibitory activities against novel 2019-nCoV protease and one of these compounds, Esculetin ethyl ester from Marine Sponges Axinella cf.

TL;DR: Two new ergosterol derivatives separated from the EtOAc extract of the endophytic fungus Fusarium chlamydosporum isolated from Anvillea garcinii (Asteraceae) leaves growing in Saudi Arabia showed moderate 5-LOX inhibitory potential compared to indomethacin.

TL;DR: Four new diterpene-type compounds normiltirone and isosalviamides F-H together with twelve known compounds were isolated from the roots of Salvia miltiorrhiza and evaluated for their ability to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.

TL;DR: In this paper, the authors used a virtual screening method to study 57 isolated phytochemicals (alkaloids, phytosterols, and flavonoids) against the SARS-CoV-2 main protease (Mpro).

TL;DR: The Olea europaea L. is a very well-known and widely used plant, especially for its nutritional qualities as discussed by the authors, and its extracts from leaves and fruits are widely used in contrasting and preventing various pathologies.