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JournalISSN: 1471-0056

Nature Reviews Genetics

About: Nature Reviews Genetics is an academic journal. The journal publishes majorly in the area(s): Genome & Genomics. It has an ISSN identifier of 1471-0056. Over the lifetime, 3853 publication(s) have been published receiving 661148 citation(s). The journal is also known as: Nature Reviews. Genetics. more


Open accessJournal ArticleDOI: 10.1038/NRG2484
Zhong Wang1, Mark Gerstein1, Michael Snyder1Institutions (1)
Abstract: RNA-Seq is a recently developed approach to transcriptome profiling that uses deep-sequencing technologies. Studies using this method have already altered our view of the extent and complexity of eukaryotic transcriptomes. RNA-Seq also provides a far more precise measurement of levels of transcripts and their isoforms than other methods. This article describes the RNA-Seq approach, the challenges associated with its application, and the advances made so far in characterizing several eukaryote transcriptomes. more

Topics: De novo transcriptome assembly (53%), RNA-Seq (51%), Transcriptome (50%)

10,295 Citations

Journal ArticleDOI: 10.1038/NRG1272
Abstract: A key aim of postgenomic biomedical research is to systematically catalogue all molecules and their interactions within a living cell. There is a clear need to understand how these molecules and the interactions between them determine the function of this enormously complex machinery, both in isolation and when surrounded by other cells. Rapid advances in network biology indicate that cellular networks are governed by universal laws and offer a new conceptual framework that could potentially revolutionize our view of biology and disease pathologies in the twenty-first century. more

Topics: Network medicine (54%), Human interactome (50%)

6,976 Citations

Open accessJournal ArticleDOI: 10.1038/NRG2626
Michael L. Metzker1Institutions (1)
Abstract: Demand has never been greater for revolutionary technologies that deliver fast, inexpensive and accurate genome information. This challenge has catalysed the development of next-generation sequencing (NGS) technologies. The inexpensive production of large volumes of sequence data is the primary advantage over conventional methods. Here, I present a technical review of template preparation, sequencing and imaging, genome alignment and assembly approaches, and recent advances in current and near-term commercially available NGS instruments. I also outline the broad range of applications for NGS technologies, in addition to providing guidelines for platform selection to address biological questions of interest. more

6,671 Citations

Open accessJournal Article
Abstract: MicroRNA (miRNA) alterations are involved in the initiation and progression of human cancer. The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery. MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein- coding genes involved in cancer. more

Topics: microRNA (52%), Carcinogenesis (51%), Epigenetics (51%) more

6,306 Citations

Open accessJournal Article
Abstract: I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer. more

Topics: Gene silencing (60%), microRNA (50%)

6,064 Citations

No. of papers from the Journal in previous years

Top Attributes

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Journal's top 5 most impactful authors

Tanita Casci

248 papers, 253 citations

Darren J. Burgess

232 papers, 573 citations

Louisa Flintoft

202 papers, 329 citations

Magdalena Skipper

179 papers, 186 citations

Linda Koch

164 papers, 360 citations

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