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JournalISSN: 1474-1733

Nature Reviews Immunology

About: Nature Reviews Immunology is an academic journal. The journal publishes majorly in the area(s): Immune system & T cell. It has an ISSN identifier of 1474-1733. Over the lifetime, 3759 publication(s) have been published receiving 674620 citation(s). The journal is also known as: Nature Reviews. Immunology. more

Topics: Immune system, T cell, Innate immune system more

Journal ArticleDOI: 10.1038/NRI1391
Shizuo Akira1, Kiyoshi Takeda2Institutions (2)
Abstract: One of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms is through the Toll-like receptors (TLRs), which recognize specific molecular patterns that are present in microbial components. Stimulation of different TLRs induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also instructs the development of antigen-specific acquired immunity. Here, we review the rapid progress that has recently improved our understanding of the molecular mechanisms that mediate TLR signalling. more

Topics: Pattern recognition receptor (65%), TIRAP (64%), TLR8 (58%) more

7,430 Citations

Open accessJournal ArticleDOI: 10.1038/NRI2448
David M. Mosser1, Justin P. Edwards1Institutions (1)
Abstract: Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions. In this Review we suggest a new grouping of macrophage populations based on three different homeostatic activities - host defence, wound healing and immune regulation. We propose that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation. We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations. more

Topics: Regulatory macrophages (59%), Macrophage polarization (57%), M2 Macrophage (55%) more

6,350 Citations

Journal ArticleDOI: 10.1038/NRI978
Siamon Gordon1Institutions (1)
Abstract: The classical pathway of interferon-gamma-dependent activation of macrophages by T helper 1 (T(H)1)-type responses is a well-established feature of cellular immunity to infection with intracellular pathogens, such as Mycobacterium tuberculosis and HIV. The concept of an alternative pathway of macrophage activation by the T(H)2-type cytokines interleukin-4 (IL-4) and IL-13 has gained credence in the past decade, to account for a distinctive macrophage phenotype that is consistent with a different role in humoral immunity and repair. In this review, I assess the evidence in favour of alternative macrophage activation in the light of macrophage heterogeneity, and define its limits and relevance to a range of immune and inflammatory conditions. more

Topics: Macrophage polarization (64%), M2 Macrophage (64%), Regulatory macrophages (60%) more

5,529 Citations

Open accessJournal ArticleDOI: 10.1038/NRI2506
Abstract: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in healthy individuals and in the context of various diseases. In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit. more

5,072 Citations

Journal ArticleDOI: 10.1038/NRI1733
Siamon Gordon1, Philip R. Taylor1Institutions (1)
Abstract: Heterogeneity of the macrophage lineage has long been recognized and, in part, is a result of the specialization of tissue macrophages in particular microenvironments. Circulating monocytes give rise to mature macrophages and are also heterogeneous themselves, although the physiological relevance of this is not completely understood. However, as we discuss here, recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues. These advances in our understanding have implications for the development of therapeutic strategies that are targeted to modify particular subpopulations of monocytes. more

Topics: Regulatory macrophages (56%), Monocyte (56%), Macrophage (52%)

4,500 Citations

No. of papers from the Journal in previous years

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Journal's top 5 most impactful authors

Yvonne Bordon

314 papers, 512 citations

Lucy Bird

305 papers, 301 citations

Kirsty Minton

295 papers, 409 citations

Olive Leavy

266 papers, 880 citations

Elaine Bell

136 papers, 159 citations

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