Showing papers in "Neoplasia in 2000"

TL;DR: OCT can be used where standard excisional biopsy is hazardous or impossible, to reduce sampling errors associated with excisionality, and to guide interventional procedures, and its potential biomedical and clinical applications are described.

TL;DR: Clinical studies to quantitatively determine normal and malignant breast tissue optical and physiological properties in human subjects show that ductal carcinomas and benign fibroadenomas exhibit 1.25 to 3-fold higher absorption than normal breast tissue.

TL;DR: A comprehensive review on steady-state and time-resolved, fluorescence measurements of neoplastic and non-neoplastic, biologic systems of varying degrees of complexity is provided.

TL;DR: It is demonstrated that inhibition of VEGF significantly prolongs survival in athymic rats inoculated in the basal ganglia with G55 human glioblastoma cells and systemic anti-VEGF inhibition causes decreased tumor vascularity as well as a marked increase in tumor cell apoptosis in intracranial tumors.

TL;DR: Translating the knowledge gained by studying the connection between cell death and cell proliferation may aid in identifying novel therapies to circumvent disease progression or improve clinical outcome.

TL;DR: The development of microCT technology for small animal imaging is reviewed, and key considerations for designing small animal microCT imaging protocols are summarized.

TL;DR: The ability of BLI to noninvasively quantitate the growth and therapeutic-induced cell kill of orthotopic rat brain tumors derived from 9L gliosarcoma cells genetically engineered to stably express firefly luciferase was investigated and provides direct validation ofBLI imaging as a powerful and quantitative tool for the assessment of antineoplastic therapies in living animals.

TL;DR: The necessity of angiogenesis-mediated absorption contrast for diagnostic optical mammography minimizes the potential for using NIR techniques to assess sentinel lymph node staging, metastatic spread, and multifocality of breast disease, among other applications.

TL;DR: Real time spatiotemporal analyses of tumor cell growth can reveal the dynamics of neoplastic disease, and facilitate rapid optimization of effective treatment regimens, and accelerate the development of therapeutic strategies.

TL;DR: A PET scanner (microPET) designed specifically for studies of small animals, and several radiolabeled probes that can be used with the HSV1-tk reporter gene both for SPECT and for PET imaging are described.

TL;DR: Research suggests that adopting AICR guidelines for diet and exercise could reduce cancer incidence by 30–40%.

TL;DR: It is shown that h TERTalpha inhibits endogenous telomerase activity, which results in telomere shortening and chromosome end-to-end fusions, which suggest a possible role for hTERT splice variants in the regulation of telomersase activity.

TL;DR: A review of recent findings about how the p53 response may be activated following cellular stress shows that posttranslational modifications of p53, such as phosphorylation, dephosphorylated, acetylation and ribosylation, have been shown to occur following Cellular stress.

TL;DR: Three alternately spliced hTERT variants that contain the alpha, beta or both alpha and beta deletion sites are introduced into normal human fibroblasts and several telomerase-positive immortal and tumor cell lines and it is found that none of the three alternate splicing variants reconstitutes telomere shortening and eventually cell death.

TL;DR: It is found that inhibition of survivin expression increased apoptosis and polyploidy while decreasing colony formation in soft agar, indicating that survivin plays important roles in a late stage of cytokinesis, as well as in apoptosis.

TL;DR: Clinical applications of magnetic resonance spectroscopic imaging (MRSI) for the study of brain and prostate cancer have expanded significantly over the past 10 years and provide evidence that the magnitude of metabolic changes in regions of cancer before therapy as well as the magnitude and time course of metabolicChanges after therapy can improve the understanding of cancer aggressiveness and mechanisms of therapeutic response.

TL;DR: Data support the conclusion that overexpression of RhoC GTPase is specifically and directly implicated in the control of the production of angiogenic factors by IBC cells.

TL;DR: A novel confocal assay in which living human breast cancer cells are observed through the use of quenched-fluorescent protein substrates is described, suggesting that a proteolytic cascade participates in pericellular digestion of matrix proteins by living human Breast cancer cells.

TL;DR: This work describes for the first time the heightened expression of COX-2 and PPARdelta, but notCOX-1, in uterine endometrial adenocarcinoma.

TL;DR: This review presents selected examples of how MR has been used to identify metabolic changes associated with apoptosis, detect therapeutic response prior to a change in tumor volume, optimize the combination of metabolic inhibitors with chemotherapy and/or radiation, characterize and exploit the influence of tumor pH on the effectiveness of chemotherapy, characterize tumor reoxygenation and the effects of modifiers of tumor oxygenation in individual tumors.

TL;DR: An important aspect of MRI and MRS studies is that techniques and findings are easily translated between systems, and pre-clinical studies using cultured cells or experimental animals have a high connectivity to potential clinical utility.

TL;DR: The simulations suggest that continuous infusion for optimal durations is superior to the other protocols, and predictions for thermosensitive liposomes indicate a potential advantage at some doses, but only if hyperthermia is applied locally so that the blood is not significantly heated.

TL;DR: Intravital microscopy application to the study of tumor-induced neovascularization further provides information on molecular transport and delivery, intra- and extravascular cell-to-cell and cell- to-matrix interaction, as well as tumor oxygenation and metabolism.

TL;DR: 5p15 gains and amplifications have been documented for various tumour types, including non-small cell lung carcinoma, squamous cell carcinoma of head and neck, and uterine cervix cancer, making hTERT a potential target.

TL;DR: Analysis of the mechanism underlying aspirin-induced apoptotic event showed that aspirin induces translocation of Bax to the mitochondria and mitochondrial release of cytochrome into the cytosol, which provides evidence that the release of Cytochrome c is an important part of the apoptotic mechanism of aspirin.

TL;DR: DNA sequence and cytogenetic analysis suggests that spontaneous telomere loss is a mechanism for chromosome instability in human cancer cells.

TL;DR: These results demonstrate key features that emphasize the potential of anti-GD3 IgTCR-modified autologous T cells for melanoma therapies and demonstrate the effectiveness of the sFv-zeta construct for clinical development.

TL;DR: This review highlights PET approaches to imaging two other aspects of tumor biology: cellular proliferation and tumor steroid receptors and reviews the biochemical and biologic processes underlying the imaging, positron-emitting radiopharmaceuticals that have been developed, quantitative image-analysis considerations, and clinical studies to date.

TL;DR: It is demonstrated that induction of apoptosis by indomethacin in esophageal adenocarcinoma cells is associated with the upregulation of Bax expression and mitochondrial cytochrome c translocation, and does not correlate with the expression of COX-2.

TL;DR: Results provide further evidence, based on the study of an endogenous gene (hprt) and an IL-8 transgene, that neutrophils may contribute to genetic instability in tumors.