Showing papers in "Neural Regeneration Research in 2013"

TL;DR: The contribution of oxidative stress and mitochondrial damage to the onset of neurodegenerative eases is summarized and strategies to modify mitochondrial dysfunction that may be attractive therapeutic interventions for the treatment of various neurodegnerative diseases are discussed.

TL;DR: Kinect-based virtual reality training could promote the recovery of upper limb motor function in subacute stroke patients, and brain reorganization by Kinect-basedvirtual reality training may be linked to the contralateral primary sensorimotor cortex.

TL;DR: In this paper, the role of autophagic process in representative chronic and acute neurodegenerative disorders is discussed and a review article provides an update of the role in these disorders.

TL;DR: In this article, the authors established a rat model of vascular dementia using permanent bilateral common carotid artery occlusion and found that resveratrol improved learning and memory ability in vascular dementia rats.

TL;DR: Data concerning neuroplasticity, physiology, and control of mitochondrial oxidative phosphorylation and reactive oxygen species production is reviewed, highlighting the importance of understanding the role of mitochondria in neuronal development and synaptic plasticity.

TL;DR: Results showed that as cognitive deficits increased across the four groups, the shortest path in the resting-state functional network gradually increased, while clustering coefficients gradually decreased, indicating that dementia is associated with a decline of brain network efficiency.

TL;DR: Therapeutic hypothermia decreases free radical produc-tion, inflammation, excitotoxicity and intracranial pressure, and improves cerebral metabolism after traumatic brain injury and cerebral ischemia, thus protecting against central nervous system dam-age.

TL;DR: This review focuses on chemotherapy-induced neurodegeneration and hippocampal dysfunctions and related mechanisms as measured by in vivo and in vitro approaches, and provides direction for the future development of novel optimized chemotherapeutic agents.

TL;DR: It is proposed that resveratrol may be a promising agent for protecting embryonic neural stem cells because of its potential to decrease oxidative stress by inducing higher activity of antioxidant enzymes, decreasing nitric oxide production and nitricoxide synthase activity, and alleviating both nuclear and mitochondrial DNA damage.

TL;DR: Puerarin pretreatment strongly protects the brain against cerebral ischemia/reperfusion injury and inhibits the inflammatory response, indicating that the anti-inflammatory effect of puerarin may partly be mediated through the activation of the cholinergic anti- inflammatory pathway.

TL;DR: If the inherent properties of endogenous Schwann cells could be developed and utilized, it would offer a new avenue for the restoration of injured spinal cord.

TL;DR: This paper retrospectively analyzed the articles published in the past 10 years that addressed the relationship between peripheral nerve compression and changes in intraneural microcirculation, with the aim of providing help for further studies in peripheral nerve micro Circulation and understanding its protective mechanism.

TL;DR: The experimental findings indicated that differentiation is important for immortalized cell lines to render post-mitotic neuronal properties, and that differentiated HT22 neurons represent a better model of hippocampal neurons than undifferentiated cells.

TL;DR: The findings suggest that regional gray matter volume abnormalities in low back pain patients are more extensive than in upper backPain patients, and subcortical gray matterVolume increases are found only in patients with low backPain.

TL;DR: This is the first report showing that Aβ25-35, a main etiological factor of Alzheimer's disease, can alter the level and metabolism of neuroactive steroids in the prefrontal cortex and hippocampus, which are brain regions significantly involved in learning and memory.

TL;DR: Overall, the results show that miR-137 suppresses Grin2A protein expression through binding to Grin1A mRNA, thereby exerting an inhibitory effect on post-stroke depression, which offers a new therapeutic direction for post- stroke depression.

TL;DR: Findings suggest that nanofibrous poly(3-hydroxybutyrate-co-3-Hydroxyvalerate) nerve conduit is suitable for repair of long-segment sciatic nerve defects.

TL;DR: It is suggested that the atypical antipsychotics, olanzapine, risperidone and aripiprazole may improve specific cognitive domains with similar global clinical efficacy.

TL;DR: It is suggested that an inertial sensor-based motion tracking system can be used in patients who have upper limb impairment through data integration with a virtual reality-based neuroretation system.

TL;DR: Long-term administration of Gastrodia elata Blume has therapeutic potential for Alzheimer's disease, and western blot analysis and Ellman method showed significant decrease in the activity of acetylcholinesterase in all three regions (prefrontal cortex, medial septum and hippocampus).

TL;DR: Experimental findings suggest that EGb761 enhances proliferation of neural stem cells in the subventricular zone and dentate gyrus, and significantly improves learning and memory in rats with vascular dementia.

TL;DR: Different levels and regions of activation for different types of reward processing during decision-making are observed, including greater activation of brain areas associated with loss when the degree of reward uncertainty increased.

TL;DR: This study examined the current status of a unit of 1 040 rescue workers who participated in earthquake relief for the Wenchuan earthquake that occurred on May 12th, 2008 to reveal the incidence of post-traumatic stress disorder.

TL;DR: The results showed that working-memory training significantly enhanced performance on the nontrained working memory tasks in children with developmental dyslexia, and interventions to improve working memory may help dyslexic children to become more proficient in reading.

TL;DR: Human umbilical cord mesenchymal stem cell-loaded amniotic membrane can be used for the repair of radial nerve injury and muscular electrophysiological function was significantly better in the transplantation group than the control group.

TL;DR: In this paper, a 13.56-MHz radio frequency hyperthermia device was used for the treatment of malignant glioma using CT-guided stereotactic apparatus.

TL;DR: The coordinative structure during walking assessed by this technique could provide further information of the body control mechanism and correlate walking pattern with injury.

TL;DR: Results showed that lactic acid was involved in seizure onset and provided energy at early stages and induces metabolic acidosis, which terminates the seizure.

TL;DR: It is demonstrated that it was the interaction of tau with GSK-3β and protein phosphatase 2A, rather than their individual activities, that dominates the phosphorylation of tAU in transient brain ischemia, which may play an important role in the evolution of brain injury in ischemic stroke.

TL;DR: It is suggested that nanofibrous poly(3-hydroxybutyrate-co-3-Hydroxyvalerate) conduit is suitable in use for repair of long-segment sciatic nerve defects.