Showing papers in "Neurobiology of Aging in 1982"

TL;DR: Studies were carried out on a group of six young and six older normal men who lived under conditions of temporal, but not social isolation, from three to eight weeks, demonstrating a reduction in the period and amplitude of the body temperature rhythms during free-running in the older group.

TL;DR: It is suggested that fragmented nocturnal sleep is a significant cause of reduced daytime well-being in elderly individuals and the continuity of both sleep and wakefulness appears to be disrupted with age.

TL;DR: The results indicate that sleep and EEG variables discriminate well for early, mild SDAT in minimally depressed aged individuals, with further change in the moderate and severe stages of dementia.

TL;DR: Dopamine and its metabolites showed a decline, statistically correlated with age, in all the dopaminergic areas considered, indicating that this system is profoundly affected in the senescent rat.

TL;DR: The method used was magnitude matching, by which subjects made numerical estimates of the perceived magnitude of various levels of the two chemical stimuli and of the loudness of low-pitched noises to compensate for individual idiosyncrasies in the use of numbers and potential biases associated with age.

TL;DR: All-night sleep EEG data were collected in relatively young and relatively unimpaired patients with presumptive Alzheimer's disease and eight age-matched controls andDelta sleep time and Delta sleep %--but not REM sleep measures--were significantly reduced in the patients.

TL;DR: It is concluded that systematic research bridging age-related differences in sleep and rhythmic phenomena in laboratory animals is lacking although several promising areas have been explored.

TL;DR: Data indicate that some specific physiological processes which are not paralleled by reported biochemical changes are affected by aging, and the mechanisms underlying these changes are subject to further investigations.

TL;DR: There were no completely consistent regional correlations between significant changes in lipid peroxidase levels and any neurotransmitter indices studied except for MAO which was only measured in the caudate-putamen.

TL;DR: The astrocytic phenomenon may represent a stage in a continuous cycle of synaptic loss and replacement in the normal brain and by 17 months, when total synapse numbers decrease, synaptic replacement may be less than optimal.

TL;DR: The overall picture is of a system in change characterized by a wide range of individual differences, and the inability to sustain sleep is clearly indexed by the sleep structure measures.

TL;DR: A slurry of aluminum powder injected into the brains of mature rabbits produced neurofibrillary changes in neurons of spinal cord and cerebrum similar to those produced by aluminum chloride, and with similar topography and rates of formation.

TL;DR: It appears that there is an age-related difference in the response of noradrenergic neurons to stress in the hypothalamus, and that apparent regional differences exist in the pattern of these changes.

TL;DR: This study is the first to report neuron loss in an animal brainstem nucleus and age pigment deposits were larger and more numerous in the MTBs of old animals, but not as extensive as has been described previously in many other parts of the nervous system.

TL;DR: The findings confirm those of an earlier report from the laboratory and suggest that age-corrected sleep variables can be developed for clinical diagnostic application, and suggest the potential utility of EEG sleep measures in the differential diagnosis of these two disorders, especially in patients with mixed symptoms.

TL;DR: Evidence is provided for neuropeptides producing behavioral improvement in non-human primates using an appetitive task, eliminating a popular criticism that the data in this literature has depended too heavily on the testing of rodents in shock-motivated tasks.

TL;DR: It is not known whether age-related changes in the ovary, pituitary, or hypothalamus are largely responsible for differences in the secretion of LH, FSH and Prl in aging C57BL/6 mice.

TL;DR: In some animals, the presence of nodal axonal swellings and of paranodal myelin retraction were expression also of a distal axonopathy, and in these animals there were also pathologic changes in the peripheral nerves and muscles.

TL;DR: It is concluded that SRBDs have a very high incidence in older males and are not usually secondary to pulmonary cardiac, neurological, or behavioral disorders, but depression of brain stem reticular formation activity during sleep plays a primary role in these disorders.

TL;DR: The profile of anterograde memory impairments observed with amitriptyline is similar to that previously reported for the antimuscarinic, scopolamine, and it appears likely that the pharmacologic blockade of central muscarinic receptors in the aged results in the selective disruption of verbal recall in secondary memory.

TL;DR: Preliminary findings suggest that the philothermal response may represent a biological marker with diagnostic usefulness for at least one subgroup of DAT patients.

TL;DR: Serum levels of somatomedins were determined in apparently healthy aged individuals and dementia patients primarily with clinically suspected Alzheimer type disorder and it was suggested that the elevated levels represent a compensatory mechanism to overcome receptor insensitivity in patients with dementia disorders of the Alzheimer type.

TL;DR: The data indicate peripheral auditory dysfunction in aged cats but little abnormality in auditory brainstem transmission with click intensity normalized for ABR threshold.

TL;DR: Capillary lumen size and capillary wall thickness remain the same throughout life, but basal lamina thickness doubles from 3 to 24 months and then remains constant from 24 to 36 months, and the incidence of several unusual ultrastructural features of the outer capillary basalLamina has been shown to increase with age.

TL;DR: It is concluded that any significant correlation between sexual behavior and hormone levels must be regarded as tentative unless repeated in successive independent studies.

TL;DR: Whole brain homogenates from rats aged 6 months (young) and 24 months (old) showed a decline with age of the pre-synaptic cholinergic marker, choline acetyltransferase, and also of total specific binding sites for the muscarinic antagonist L(-)quinuclidinyl benzilate (L-QNB).

TL;DR: The results suggest that HR, SP, and P3 responses may reflect physiological processes related to the slower RTs of healthy elderly subjects.

TL;DR: Changes with age in responses to stress of certain central monoaminergic systems were investigated, and the 18 and 29-month-old rats presented enhanced serotonergic tonus, indicated by the greater increase in 5HIAA determined by stress.

TL;DR: The increase in d' indicates that physostigmine enhanced storage of information in memory while the change in C is consistent with the view that patients altered their decision criteria to maximize the number of correct responses in both conditions.

TL;DR: The data suggest that persistent hyperprolactinemia rather than impaired LH secretory mechanisms is primarily responsible for the PP state in old Fischer 344 rats.