Showing papers in "Neurobiology of Aging in 2000"

TL;DR: By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.

TL;DR: Elevated levels of blood pressure in middle age can increase the risk for late age dementia in men never treated with anti-hypertensive medication, and these results were consistent for Alzheimer's disease and vascular dementia.

TL;DR: In this article, current knowledge on the relation between vascular risk factors and Alzheimer's disease is reviewed, and the authors suggest that the risk factors for vascular disease and stroke are associated with cognitive impairment and Alzheimer’s disease, and that the presence of cerebrovascular disease intensifies the presence and severity of the clinical symptoms of Alzheimer's diseases.

TL;DR: It is proposed that cerebral ischemia or oligemia may promote Alzheimer type of changes in the aging brain, and that management of peripheral vascular disease is important in the treatment or prevention of Alzheimer's disease or mixed dementia.

TL;DR: The results suggest a specific defect of COX in the AD brain versus the normal human brain, which may contribute to impaired energy generation and biochemically is confined to selected brain regions, suggesting anatomic specificity.

TL;DR: Results indicate that in addition to the accepted association of high BP with neuropathic cerebrovascular lesions, there is a direct relationship with brain atrophy, NP and NFT.

TL;DR: A logistic regression model of baseline EEG values adjusted for baseline Mini-Mental Test Examination showed that the important predictors were alpha and theta relative power and mean frequency from left temporo-occipital derivation (T5-O1), which classified 85% of MCI subjects correctly.

TL;DR: It is suggested that repeated treatment with estrogen and progesterone initiated within a specific period of time after the loss of ovarian function may be effective at preventing specific negative effects of hormone deprivation on brain aging and cognitive decline.

TL;DR: The results indicate that the previously demonstrated age-related decline in striatal dopamine D2 receptors extends to several extrastriatal regions in normal human males, and the rate of D2/3R decline may be faster in the frontal cortex as compared to the temporal and thalamic regions.

TL;DR: Logistic regression analyses indicate that the medial occipitotemporal and the combined middle and inferior temporal gyri may be the first temporal lobe neocortical sites affected in AD; atrophy in these areas may herald the presence of future AD among nondemented individuals.

TL;DR: A wide range of dementia-associated mental and behavioral disturbances afflict the majority of individuals with dementia, and these disturbances should be ascertained and treated in all cases of dementia.

TL;DR: It is suggested that the formation of the MCI epitope is one of the earliest pathological alterations of tau in AD.

TL;DR: The concept that advanced aging in the presence of a vascular risk factor can converge to create a critically attained threshold of cerebral hypoperfusion (CATCH) that triggers regional brain microcirculatory disturbances and impairs optimal delivery of energy substrates needed for normal brain cell function is proposed.

TL;DR: Group differences in longitudinal change in rCBF patterns may reflect one way through which hormones modulate brain activity and contribute to enhanced memory performance among ERT users.

TL;DR: The findings raise the question of the potential implication of apoAI in the etiopathology of AD and bring serum apo AI concentration to the fore as an important biochemical marker.

TL;DR: Alzheimer's disease is manifested by core features of progressive memory impairment, visuospatial decline, aphasia, and loss of executive function, and patients may evidence a variety of other cognitive and behavioral features.

TL;DR: It is demonstrated that neurons containing characteristic lesions in a subset of diseases, including Down Syndrome, Frontotemporal Dementia linked to chromosome 17, Progressive Supranuclear Palsy, and Pick's disease, display mitotic indices, implicating diverse etiologies in mitotic activation.

TL;DR: Because NO modulates activities including cerebral blood flow and memory, and reduced NO production has been observed in AD brain, stimulation of NO production by L-deprenyl could contribute to the enhancement of cognitive function in AD.

TL;DR: Putative risk factors accelerating mild cognitive decline and dementia were correlated with repeated measures of cerebral atrophy, CT, densitometry, perfusions, and cognitive testing among neurologically and cognitively normative aging volunteers.

TL;DR: There is sufficient evidence to take seriously the possibility that depression is a risk factor for dementia and cognitive decline and further work is needed to examine depression as a prodrome of vascular dementia, depression as an early reaction to perceived cognitive decline, the effects of depression on the threshold for manifesting dementia, and Depression as a source of hippocampal damage through a glucocorticoid cascade.

TL;DR: This review focuses on apoE research, from clinical studies to animal models, in AD, acute brain injury and cerebrovascular disease and explores the common mechanisms that may explain some of the complex underlying neurobiology.

TL;DR: Examining the distribution of agrin and laminin within the VBM, and measuring the agrin concentration within hippocampus and prefrontal cortex, suggest that agrin is an important VBM-associated HSPG in the brain and that Agrin levels are altered in association with microvascular damage in AD.

TL;DR: The manner in which the brain responds to the environment with advancing age is highly genetically determined, both for the lateral ventricles, which dilate with aging and disease, and for the corpus callosum, which is deformed in shape by age-related ventricular enlargement, whereas its midline cross-sectional area remains unchanged.

TL;DR: It is found that the CDK inhibitor, flavopiridol blocks the delayed death of cultured cortical neurons evoked by 3-nitroproprionic acid treatment and that the NMDA antagonist, MK801 provides short term protection in this model.

TL;DR: Dementia was significantly correlated only with the volume density of Abeta deposits and the numerical density of NFT, and the intellectual deficit seemed to be more significantly related to the latter two lesions than to the microglia-amyloid complex, that was visible at an earlier stage.

TL;DR: This poster presents a poster presented at the 2016 American Academy of Neurology Congress entitled “Neuroscience Discovery Research: Advances in Neurosurgery and Nervous System Injury: Foundations of Neuroscience and Toxicology.”

TL;DR: Cortical patterns of β-amyloid deposition were evaluated in beagle dogs and it may be possible to predict the presence of Aβ within specific brain regions in individual dogs by using parameters derived from regression analyses.

TL;DR: The colocalization of the kinase Cki delta and its apparent substrate tau suggests a function for CkiDelta in the abnormal processing of tau in Alzheimer's disease.

TL;DR: It is found that when weak orthodromic stimulation of medial perforant path fibers is paired with intracellular current injection of granule cells, the threshold for LTP induction is elevated in aged, spatial memory-impaired rats compared to middle-aged and young controls, suggesting that greater depolarization and input convergence is required before durable modification of synaptic strength can be induced.

TL;DR: Parenchymal Abeta deposition seems to be a common correlate of behavioral problems in aging dogs, and Multivariate analysis showed that the age and the extension index explained most of the variance.