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Showing papers in "NeuroImage in 1994"


Journal ArticleDOI
TL;DR: This serial-tomography method allows the use of sufficiently thin sections to achieve adequate resolution with electron tomography, yet enables the generation of large reconstructions with considerably fewer sections than would be required using a serial thin section reconstruction technique.

130 citations


Journal ArticleDOI
TL;DR: A method for analyzing electrical activity called "cordance" that has face validity as a measure of cortical deafferentation is developed and demonstrated strong associations between cordance and other measures of brain structure and function.

120 citations


Journal ArticleDOI
TL;DR: A satisfactory agreement between noninterpolated confocal measurements and the Cavalieri estimates suggests that less-stringent optical sectioning parameters may suffice for individual cell volume measurements when using confocal microscopy, thus making it significantly more efficient.

67 citations


Journal ArticleDOI
TL;DR: A spatially accurate, high-resolution three-dimensional (3D) volume of brain anatomy from cryosectioned whole human head is generated as an educational, clinical, and research resource.

48 citations


Journal ArticleDOI
TL;DR: Using a CCD, a system which enables the repeatable imaging of rapid function in rodent primary somatosensory cortex (S-I), based on activity-related changes in its optical reflectance (intrinsic signals), is developed.

44 citations


Journal ArticleDOI
TL;DR: Two methods of estimating volumes from images of brain structures were compared and evaluated, with Pixel counting proved to be the more robust of the two methods, being less sensitive to nuisance-interactions between size of object, shape, and slice thickness.

36 citations


Journal ArticleDOI
TL;DR: A three-dimensional (3D) digital atlas of a mouse lemur head at 60-micron cubic voxel isotropic resolution is presented, constructed from a 3D proton magnetic resonance image (MRI) acquired at 500 MHz.

28 citations


Journal ArticleDOI
TL;DR: The laser scanning confocal microscope, when used with the krypton-argon ion laser, is well suited for the simultaneous detection of pairs of antigens by immunofluorescence, but the use of fluorophores excited by the 488 nm line produces unsatisfactory results when tissue contains low wavelength-excitable aut ofluorescence.

27 citations


Journal ArticleDOI
TL;DR: Results indicate that autoradiographic images of the rat brain obtained with [11C]physostigmine reflect AChE distribution, thus supporting the use of this radioligand to trace cerebral A cholinesterase activity in humans with positron emission tomography.

24 citations


Journal ArticleDOI
TL;DR: High-resolution MRI was used to examine the brain of this mutant, an animal model for the study of human phenylketonuria, and revealed no evidence of demyelination or other abnormalities in the brains of Pah(enu2) mice.

24 citations


Journal ArticleDOI
TL;DR: The results demonstrate that specific cell types in developing rat cerebellum can be identified after acute isolation, which should facilitate analysis of their endogenous properties.

Journal ArticleDOI
TL;DR: Using a computerized three-dimensional reconstruction technique with serially sectioned rat embryos, changes in the size and form of the forebrain were studied on Embryonic Days (E) 12, E15, E18, and E21, showing that the majority of diencephalic structures develop earlier than those in the telencephalon.

Journal ArticleDOI
TL;DR: Responses of the hamster suprachiasmatic nucleus (SCN) to retinohypothalamic tract (RHT) stimulation were studied in horizontal hypothalamic slices using fast multisite optical recording techniques and showed that both SCN components had similar spatial distributions within the SCN, although the Early P.E.P.S.P.'s tended to be slightly more prominent within the medial SCN in some preparations.

Journal ArticleDOI
TL;DR: A computer image analysis procedure for counting autoradiographic grains in in situ hybridization experiments revealed a significant correlation between human and computer estimations of grain number and consistently underestimated the number of grains when grain density was high.

Journal ArticleDOI
TL;DR: The cellular and functional specificity of these fluorescent lipid probes shows great promise for monitoring biochemical events in complex neuronal systems with significant spatial and temporal resolution.

Journal ArticleDOI
TL;DR: Positively charged, nonspecific protein stain SFRM-B displays greater photostability and less leakage than the positively charged acridine orange, and its fluorescence persists for hours, whereas acridin orange fluorescence fades within 1 min when exposed to ultraviolet illumination.

Journal ArticleDOI
TL;DR: Developmental study showed that primitive glomeruli lacking the internal structure of the adult form first appear in the 22-day embryo and that the characteristic internal structureOf the glomerulus develops mainly during postnatal days, and the confocal laser scanning image method together with specific molecular markers provides a simple tool for the three-dimensional analysis of theglomerular structure.

Journal ArticleDOI
TL;DR: It is demonstrated that HBO treatment does not reduce the blood-brain barrier (BBB) disturbance and cerebral edema in EAE, that in an opposite way, it provokes reversible BBB breakdown, and that preventive HBO treatments results in modification of the course of EAE.