Showing papers in "Neuron in 1988"

TL;DR: It is concluded that the nonpermissive substrate properties of CNS white matter are due to these membrane proteins on the surface of differentiated oligodendrocytes and to their in vivo product, myelin.

TL;DR: expression of mRNA has yet to be observed in brain or selected peripheral tissues, suggesting that either it is substantially less abundant than m1-m4 or its distribution is quite different.

TL;DR: TAG-1 is immunochemically distinct from the cell adhesion molecules N-CAM and L1 (NILE) and is expressed on commissural and motor neurons over the period of initial axon extension, evidence that axonal guidance and pathway selection in vertebrates may be regulated in part by the transient and selective expression of distinct surface glycoproteins on subsets of developing neurons.

TL;DR: NGFI-B, as a possible ligand-dependent transcriptional activator induced by NGF, may play a role in initiating NGF-induced differentiation.

TL;DR: The magnitude and displacement dependence of the gating compliance provide quantitative information about the molecular basis of mechanoelectrical transduction: the force required to open each channel, the number of transduction channels per hair cell, the stiffness of a gating spring, and the swing of a channel's gate as it opens.

TL;DR: A scheme for cellular determination in the Xenopus retina is presented in which a coherent group of clonally related cells stretch out radially as lamination begins, which brings different cells into different microenvironments.

TL;DR: In vitro assay for MR and GR function demonstrates that these receptors respond to different levels of glucocorticoid, suggesting that together they confer a larger dynamic range of sensitivity to this hormone, leading to a new hypothesis for glucoc Corticosteroid action in the central nervous system.

TL;DR: To analyze cell lineage in the murine cerebral cortex, progenitor cells were infected with a recombinant retrovirus, then the retroviral gene product was used to identify the descendants of infected cells, and neuronal and glial lineages appear to diverge early in cortical development.

TL;DR: It was found that postnatal ganglion cells differed in antigenic, morphological, and intrinsic electrophysiological characteristics, and that these properties were correlated with one another.

TL;DR: The antigenic sites for five monoclonal antibodies that react with tau and cross-react with SDS-extracted neurofibrillary tangles are defined and mapped epitopes were found to span almost the entire length of tau, suggesting that PHF contains tau in its entirety or nearly in its entire.

TL;DR: The enhancement of synaptic transmission during LTP is caused by an increased sensitivity of the postsynaptic neuron to synaptically released glutamate, and the novel physiological properties of excitatory synaptic transmission in the CA1 region of the hippocampus are examined.

TL;DR: It is proposed that calcium influx and calpain I activation provide a mechanism by which neuronal activity regulates the degradation of specific neuronal structural proteins and may thereby modify neuronal morphology.

TL;DR: The results indicate that the pre- and postsynaptic effects mediated by GABAB receptors in hippocampus have distinctly different pharmacological properties and possibly a different coupling mechanism.

TL;DR: RNA blot analyses show that one of the mRNAs is expressed selectively in the nervous system, that the two messages display different regional distributions in the adult human brain, and that the expression of the two m RNAs is differentially affected in Down's syndrome brain and in Alzheimer's disease frontal cortex.

TL;DR: Since N-cadherin and integrin beta 1 antibodies together virtually eliminated E8 CG neurite outgrowth on cultured astrocytes, these two neuronal receptors are probably important in regulating axon growth on astroglia in vivo.

TL;DR: The intensity of per-specific staining in the visual system was found to oscillate, defining a free-running circadian rhythm with a peak in the middle of the night.

TL;DR: It is demonstrated that cell lines expressing an antigenic marker specific for a major brain precursor cell population can be established from rat cerebellum and express the precursor, neuronal or glial properties depending on the growth conditions.

TL;DR: A full-length rat brain Na + channel α subunit cDNA is constructed that differs from the previously reported a subunit of Noda et al. at 6 amino acid positions indicating the presence of a component, either a structural sub unit of the channel complex or a modifying enzyme, necessary for normal gating of the channels.

TL;DR: The axoplasm at the presynaptic active zone of excitatory synapses between parallel fibers and Purkinje cell spines contains a meshwork of distinct filaments intermingled with synaptic vesicles, seen most clearly after the rapid freezing, freeze-etch technique of tissue preparation.

TL;DR: It is concluded that the carboxyl third of tau is tightly bound to PHF.

TL;DR: The corticopontine projection develops by an interstitial budding of collaterals from parent axons rather than a reported mechanism of axon branching, growth cone bifurcation, which is used regardless of whether the parent axon's postpontine segment is permanent or transient.

TL;DR: It is proposed that the nervous system expresses diverse forms of neuronal nicotinic acetylcholine receptors by combining β2 subunits with different agonist-binding α subunits.

TL;DR: 18 additional Sh cDNAs are isolated and examined in an attempt to understand the origin, extent, and significance of the variability of the Shaker (Sh) locus.

TL;DR: In this paper, the Ca 2+ indicator fura-2 in frog sympathetic neurons was spatially resolved by digital imaging with the CA 2+ indicators fura 2 in frog nervous system.

TL;DR: Regulation of the presence of beta-Thr382 in the holoenzyme by both differential gene expression and alternative splicing suggests that it may have an important but highly specialized function.

TL;DR: It is found that the P0 extracellular domain is similar in structure to a single immunoglobulin variable region domain, and the partitioning of which provides genetic evidence for the evolution of immunoglOBulin-related domains from an ancestral half-domain.