Showing papers in "Neuropeptides in 1992"

TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.

TL;DR: Results indicate areas where GLP-1(7-36) amide may have a role as a neurotransmitter or neuromodulator, and placeable binding of the label was sharply localized to discrete areas.

TL;DR: The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat by investigating the responses to subcutaneous formalin and electrical C-fibre stimulation.

TL;DR: These results demonstrate complex, region-specific interactions between cocaine and the neurohypophyseal hormones in the brain and in the periphery underlying the alteration in behavioral and autonomic functions caused by acute and chronic cocaine exposure.

TL;DR: The effects of devazepide and L-365,260, CCK antagonists, on morphine antinociception appear to be dependent on the animal's response to a new environment or to the stress induced by an unaccustomed experimental paradigm.

TL;DR: The results suggest the coexistence of functional NK1 and NK2 receptors and it appears that in this mast cell line neurokinin-induced histamine release is primarily mediated by the NK2 receptor, characterized biochemically as a low affinity binding site with a Kd value of 40 nM for SP.

TL;DR: Two peptides, enkephalin (ENK) and corticotropin releasing factor (CRF) are present in specific populations of climbing fibers and mossy fibers, which have an overlapping distribution in several areas of the cerebellum, in particular the lateral aspect of vermal lobules VII and VIII, where ENK and CRF have opposite effects on Purkinje cell activity.

TL;DR: CCK8s may attenuate beta-endorphin-induced inhibition of the tail-flick response by inhibiting the release of Met-enkephalin from the spinal cord.

TL;DR: Two types of CGRP responses in the guinea pig basilar artery are suggested: alpha-C GRP induced relaxation is blocked by the antagonist hCGRP(8-37), while the equally strong dilator response to beta-CGRp is not antagonized.

TL;DR: It is shown that GABAergic afferents arising from the medial septal area extensively innervate neuropeptide Y-containing neurons in the hippocampal formation of the rat.

TL;DR: This result confirms that septide, [pGlu6, Pro9]SP(6-11), a peptide active in the guinea-pig ileum bioassay and practically devoid of binding potencies for the three specific NK-1, NK-2 and NK-3 tachykinin binding sites interacts with a tachyKinin receptor different from theNK-1 receptor sensitive to [Pro 9]SP.

TL;DR: It is suggested that iv injected TNF-alpha and interleukin-1 may share a common site of action in the brain, such as the ME, to stimulate CRH secretion.

TL;DR: The present work provides further evidence that RP 67580 and (+/-) CP-96,345 exert in vitro a potent, selective and competitive antagonistic action on NK1 receptors and suggests the existence of at least two distinct NK1 receptor subtypes in some guinea-pig peripheral organs.

TL;DR: The increased level of proenkephalin and prodynorphin opioid peptides in brain structures, essential for the appearance of spike-wave discharges, suggests that these opioid systems, but not proopiomelanocortin one, may play a role in absence epilepsy.

TL;DR: Few immunoreactive fibers were visualized in the interpeduncular nucleus, cuneiform nucleus, locus coeruleus, nucleus incertus, superior and inferior central nuclei, nucleus sagulum, ventral nucleus of the lateral lemniscs, nucleus praepositus hypoglosii, medial vestibular nucleus, Kölliker-Fuse area.

TL;DR: It is suggested that NT differentially affects in vivo DA release in the striatum and nucleus accumbens, and further strengthens the assertion that NT is an important modulator of dopaminergic function.

TL;DR: These observations correlate with the effects of neuropeptides on serous cell lactoferrin secretion, and the presence of specific GRP, SP, and VIP binding sites on human nasal submucosal glands that have been detected by autoradiography.

TL;DR: It is shown that corticotropin releasing factor stimulates ‘in vitro’ the migration of human monocytes, the maximum effect being obtained at 10 −14 M.

TL;DR: It is argued that a new biological role has probably been acquired by ACTH in higher vertebrates, where it is also expressed in cells belonging to the lymphocyte lineage, possibly exerting a regulatory role on antibody response.

TL;DR: The rat insulinoma RIN 5F and the mouse pituitary AtT-20 cell line, which are known to express several biologically active peptides, were found to express CCK mRNA, to correctly process, and to release immunoreactive cholecystokinin (CCK) peptides.

TL;DR: It is concluded that CGRP might be able to lengthen the passive avoidance latency by facilitating learning and memory formation.

TL;DR: Findings may indicate the possible role of somatostatin in the pathogenesis of common migraine, and support earlier observations that beta-endorphin is involved in the development in this disorder.

TL;DR: Increased rates of glucose metabolism among many other nuclei, particularly distinct subunits of the hippocampal formation and structures in contact with the ventricular system, signify that endothelin induced widespread metabolic stimulation over much of the neuraxis.

TL;DR: The results suggest a possible alteration of the endothelin-1 system in the central nervous system in Alzheimer's disease.

TL;DR: It is found that intraventricular injection of 9 pmol of ET reduced rates of perfusion by an average of 29% and a significant vasoconstrictor effect occurred in the ipsilateral choroid plexus after ET injection, despite its increased rate of glucose metabolism.

TL;DR: The findings that FMRFamide-related peptides (FaRPs) are weak agonists at opioid receptors and appear to reconcile the apparently chimeric agonist and antagonist properties of these peptides observed in vivo are consistent with the view that F-Met2]-FMRFamilial antinociception and attenuated morphine-induced ant inociceptive properties are consistent.

TL;DR: It was found that TRH, but not other compounds investigated herein, increased the thymus cell proliferation 12 hours after the injection.

TL;DR: Three peptides tested are likely to be involved in the pathophysiology of acute intestinal inflammation and substance P may play a role in the transmission of nociceptive signals from the inflamed colonic segment.

TL;DR: The data suggest that TRH and TRH mRNA are present in the rat heart, but their concentrations are dissociated, possibly because of differential post-transcriptional or post- translational processing.

TL;DR: Cell-specific expression in subpopulations of cerebrocortical neurons suggest that chromogranin A and B gene products may play a role in central neuronal function.