Showing papers in "Neuroscience Letters in 1995"

TL;DR: The results support the involvement of immunological events in the complex process of neurodegeneration in AD and PD.

TL;DR: By a combination of site-directed mutagenesis of recombinant tau and in vitro phosphorylation, it is shown that AT8 requires tau protein to be phosphorylated at both serine 202 and threonine 205 (using the numbering of the longest human brain tau isoform).

TL;DR: It is demonstrated that subdiaphragmatic vagal transection disrupts the hyperthermia-inducing effects of recombinant human IL-1 beta and stress, providing evidence for a novel route of immune-brain communication, as well as a novel routes whereby stress can influence physiological processes.

TL;DR: An experiment replicates findings which showed that listening to a Mozart piano sonata produced significant short-term enhancement of spatial-temporal reasoning in college students, and shows that 'repetitive' music does not enhance reasoning; a taped short story does not enhancing reasoning; and long-term memory is not enhanced.

TL;DR: The anatomical findings provide a reasonable explanation for the action of the exogenous peripheral glutamate, namely that activation of these receptors leads to increased primary afferent activity in unmyelinated axons and thus to pain behaviors.

TL;DR: Results show that STN-HFS exerts an inhibitory influence on the basal ganglia output structures similar to that obtained by STN lesion.

TL;DR: Brain pH declined with increasing age at death and was related to agonal state severity, but was independent of postmortem interval and the histological presence of hypoxic changes, and provides a simple means to improve human brain gene expression studies.

TL;DR: Production of these enzymes by glia or infiltrating inflammatory cells could therefore contribute to demyelination in neuroinflammatory disease.

TL;DR: This is the first report showing that LTP of C-fiber-evoked field potentials in the spinal dorsal horn in vivo may last for more than 8 h, and may underlie plastic changes of spinal nociception.

TL;DR: The extent to which higher order corticopontine projections are derived from prefrontal associative cortices are determined by injecting anterograde tracers into multiple prefrontal regions in rhesus monkeys by strengthening the observation that the cerebrocerebellar system incorporates associative cerebral regions.

TL;DR: Results suggest that nitration of protein-tyrosine residue is upregulated in motor neurons of the spinal cord of ALS.

TL;DR: The results suggest that ketobemidone and methadone may be useful therapeutic agents in conditions where a combined opiate agonist and NMDA antagonist treatment is desired.

TL;DR: A significant reduction in global cerebral metabolic rate for glucose was found when compared with 16 age-matched controls and there was a focal, parieto-temporal deficit similar to, although less extensive than, that found in 18 symptomatic individuals from familial Alzheimer's disease (FAD) pedigrees.

TL;DR: In this article, the authors evaluated the behavior of 16 male Ts(17 16 )65Dn mice (TS) and 16 control mice (CO) compared to their CO littermates in the Morris water maze.

TL;DR: Four continuous cell lines of human microglial cells were obtained by transfection of enriched cultures of human embryonic brain-derived macrophages with a plasmid encoding for the large T antigen of SV40 with the macrophagic characteristics of adherence and intra-cytoplasmic non-specific esterase activity.

TL;DR: It is hypothesized that the increase in mediolateral activity in subjects with IPD may reflect an attempt to maintain potentially stabilizing movements during quiet standing in the face of impaired movement in the anteroposterior direction.

TL;DR: The results suggest that inflammation around the nerve is critical for the development of guarding behavior and thermal hyperalgesia in this model of neuropathic pain.

TL;DR: It is shown that apoE-deficient mice have cholinergic deficits and the importance of this mouse model for studying the interactions between apolipoprotein E and the Cholinergic nervous system is highlighted.

TL;DR: It is reported that transient transfection of human GSK3 beta into Chinese hamster ovary cells stably transfected with individual human tau isoforms leads to hyperphosphorylation of tau at all the sites investigated with phosphorylation-dependent anti-tau antibodies.

TL;DR: Roles for both IL-1 and IL-6 in the neuronal mechanisms related to beta-amyloid protein deposition in AD are suggested.

TL;DR: This is the first demonstration that cells can reversibly inhibit mitochondrial respiration via NO production, and this inhibition is large and potentially important in a range of pathophysiological conditions.

TL;DR: In this paper, EEG responses recorded over the occipital lobe showed an increase of 40 Hz spectral power when a regular pattern of moving bars appeared, and the enhancement varied as a function of visual field presentation.

TL;DR: Dose dependent reduction of allodynia was observed after I.P. and ICV morphine, but not after IT morphine, IT or ICV c[D-pen2 D-pen5]enkephalin (DPDPE) (delta agonist), or IT orICV U50488H (kappa agonist).

TL;DR: The startle response elicited when the subject's attention was focused onto reacting to the visual 'go' signal involved more muscles and induced larger EMG responses than when the startling stimulus was delivered unexpectedly.

TL;DR: In rats that received intraperitoneally L-DOPA plus a peripheral decarboxylase inhibitor, it was shown by use of a double-labeling immunofluorescence method that dopamine was localized in serotonergic fibers of the striatum and cerebral cortex as well as inserotonergic cell bodies of the midbrain raphe nuclei.

TL;DR: Following ventral root avulsion and 4 weeks of continuous treatment, BDNF, but not CNTF, was found to prevent cell death and NOS expression in the lesioned motoneurons, suggesting a therapeutic potential for BDNF in the adult nervous system, possibly through blockage of nitric oxide synthesis.

TL;DR: The results suggest that the visual cortex of blind humans can participate in auditory discrimination, and a whole-scalp magnetometer with 122 planar gradiometers is used to study this activity.

TL;DR: Findings suggest a central inhibitory effect of cold sensitive A-delta fibre activation on itch, which is related to histamine-induced itch, wheal and flare reactions of the left lower arm.

TL;DR: Serum and CSF levels were correlated to the daily dose, but not to the duration of treatment, and memantine is expected to specifically interact with the PCP binding site of the NMDA receptor.

TL;DR: The neuronal cannabinoid receptor clone was expressed of saturable [3H]WIN 55,212-2 binding sites and co-expression of the cannabinoid receptor with cRNA coding for the G-protein-gated inwardly rectifying K+ channel (GIRK1) resulted in oocytes exhibiting large inward K+ currents in response to the cannabinoid agonists.