Showing papers in "Neuroscience Letters in 2001"

TL;DR: This work proposes selective associations of theta and alpha oscillating networks activity with states of internalized attention and positive emotional experience in brain regions involved in meditative states.

TL;DR: Observations provide the first direct evidence that inhibition of the ubiquitin-proteasome pathway leading to altered protein handling and Lewy body formation may be responsible for degeneration of the nigrostriatal pathway in idiopathic PD.

TL;DR: It is suggested that protective antioxidant gene responses are insufficient to counteract the increased oxidative damage of proteins in a vulnerable region of the AD brain.

TL;DR: CSF levels of kynurenic acid in schizophrenic patients were found to correlate with age, which is indicative of a contribution of kysine-site of the N-methyl D-aspartate-receptor in the pathogenesis of schizophrenia.

TL;DR: Findings suggest that total tau and phospho-t Tau in CSF reflect different pathogenic processes in the brain; total-tau the degree of neuronal damage and phosphO-tAU the phosphorylation state of t Tau and thus possibly the formation of neurofibrillary tangles.

TL;DR: The results suggest that deficient degradation of beta-amyloid protein caused by low levels of neprilysin may contribute to AD pathogenesis.

TL;DR: Analysis of neuropathological events in a transgenic mouse model expressing human mutant beta-amyloid precursor protein and human mutant presenilin-1 in neurons revealed that intracellular Abeta staining preceded plaque deposition, which started in the hippocampal formation.

TL;DR: It is suggested that MSCs injected intrastriatally survive, express dopaminergic protein TH immunoreactivity, and promote functional recovery in mice treated with MPTP.

TL;DR: Paired-pulse TMS provides a non-invasive means of studying age-related functional changes in the motor cortex and demonstrates that normal aging is associated with a relative decrease in the excitability of intracortical inhibitory circuits.

TL;DR: The results suggest that these compounds may be protecting the cells from betaA(1-42) insult through antioxidant pathway through antioxidants pathway.

TL;DR: A lack of correlation between CSF Aβ40 and Aβ42 levels with those of plasma suggests that Aβ in CSF and plasma originates from different sources, and the data suggest that plasma ACT crosses the blood–brain barrier.

TL;DR: The data suggested that the hypothalamus might characterize the central expression of acupuncture stimulation at the classical analgesic point and serve as one key element in mediating analgesic efficacy ofupuncture stimulation.

TL;DR: The findings document that valence discrimination is associated with the early (200-500 ms poststimulus) time-locked synchronized theta activity as well as hemispheric asymmetries in anterior-posterior direction.

TL;DR: It is concluded that gymnasts are able to use the remaining sensory modalities to compensate for the lack of vision in unstable postures.

TL;DR: The limited, but significant depression of the neuronal HVA Ca(2+) current, produced by LEV at a clinically relevant concentration, might contribute to the antiepileptic action of the drug.

TL;DR: Joke comprehension has been decomposed into surprise registration followed by a coherence stage, involving frame-shifting (retrieving a new frame from long-term memory to reinterpret information in working memory), which is examined by recording event-related brain potentials from adults reading one-line jokes or non-joke controls with equally unexpected endings.

TL;DR: In concentration-clamp experiments, the effects of the uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists memantine, amantadine and MRZ 2/579 on 5-HT receptors stabley expressed in HEK-293 cells and on native 5- HT(3) receptors in the N1E-115 cell line were investigated.

TL;DR: The dynamic changes in the mechanisms for cholesterol efflux from the brain are of interest in relation to the link between brain cholesterol and amyloid beta-protein in AD.

TL;DR: This study has validated SHIRPA using a large cohort with one single mutation, 'legs at odd angles that causes neurological dysfunction', and this is the first longitudinalSHIRPA analysis.

TL;DR: It is found that congenital deafness can enhance the accuracy of suprathreshold tactile change detection while tactile frequency discrimination is not significantly changed, although there is a trend toward reduced thresholds.

TL;DR: This is the first demonstration of the feasibility of transiently disrupting the cerebellum by rTMS and inducing behavioral effects, and this method of 'virtual lesions' can expand the study of the role of the Cerebellum in motor control and cognition.

TL;DR: Because a memory trace is lacking for new pictures, the increase in theta during retrieval reflects primarily general processing demands of a complex episodic memory system.

TL;DR: The results suggest that the investigated 5-HT2A and 5- HTTLPR polymorphisms are not major susceptibility factors in the etiology of major depression, however, subtypes might be identified at least on a basis of differential treatment response.

TL;DR: First direct evidence that claudin-11 besides claud in-1 and -2, occludin and the zonula occlUDens protein ZO-1 is present in choroid plexus epithelial tight junctions is presented.

TL;DR: It is suggested that oxidative stress plays an active role in ALS and the potential for treatment strategies aimed specifically against ROS is illustrated.

TL;DR: The results suggest that the mechanisms for feeding of the neonatal chick through GH release are different from mammal, and ghrelin in a dose-dependent manner.

TL;DR: Evidence is provided that the decreased dopaminergic function in the right caudate nucleus is related to the impaired performance in tests sensitive to frontal lobe function in patients at an early stage of PD and with no antiparkinsonian medication.

TL;DR: In vitro and in situ evidence is presented that, like amyloid beta peptide (Abeta), tau, the major protein constituent of the neurofibrillary tangle, is a potent, antibody-independent activator of the classical complement pathway.

TL;DR: The distribution pattern and mRNA expression levels of AQP4 were examined in a severe traumatic brain injury model by immunohistochemistry and reverse transcription-polymerase chain reaction to provide basic information for investigating new treatments for traumatic brain oedema.

TL;DR: It is suggested that it is necessary to differentiate between cues from plantar cutaneous receptors involved in exteroceptive functions, like the evaluation of the support structure or of relative foot-to-surface motion, and cues from deep receptors which subserve proprioception functions like the control of center of pressure shifts within the limits of the foot support base.