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Showing papers in "Neuroscience Letters in 2004"


Journal ArticleDOI
TL;DR: Recent findings on the peripheral mechanisms of action of three prototypic proinflammatory cytokines, interleukin-1beta, interLEukin -6 and tumor necrosis factor-alpha, with regards to pain and hyperalgesia are summarized.

798 citations


Journal ArticleDOI
Ji-Sheng Han1
TL;DR: A combination of the two frequencies produces a simultaneous release of all four opioid peptides, resulting in a maximal therapeutic effect, verified in clinical studies in patients with various kinds of chronic pain including low back pain and diabetic neuropathic pain.

718 citations


Journal ArticleDOI
TL;DR: MEG recordings of five healthy human subjects were converted to sparsely connected graphs by applying a suitable threshold to the N * N matrix of synchronization strengths, and synchronization patterns were similar to those of an ordered graph with a consistent drop of synchronization strength as a function of distance.

546 citations


Journal ArticleDOI
TL;DR: Emotional effects observed on P1, P2 and P3b showed that the valence content of the stimulus modulates the cognitive processes at several points in the information processing stream.

320 citations


Journal ArticleDOI
TL;DR: Bone marrow mesenchymal stem cells can trans-differentiate into neuronal phenotypes in culture and during nerve regeneration, indicating glial differentiation in response to local cytokines and growth factors.

298 citations


Journal ArticleDOI
TL;DR: The results were independent of APOE genotype, demonstrating that the effect of mt variation is not confounded by APOE4 carrier status, and suggest that variations within haplogroup U may be involved in AD expression in combination with environmental exposures or nuclear proteins other than APOE.

280 citations


Journal ArticleDOI
TL;DR: The results suggest that spinal pain and aging may lead to changes in postural control by refocusing proprioceptive sensitivity from the trunk to the ankles.

259 citations


Journal ArticleDOI
TL;DR: It is reported that crocin is a unique and potent antioxidant that combats oxidative stress in neurons and was more effective than those of alpha-tocopherol at the same concentration.

246 citations


Journal ArticleDOI
TL;DR: It is suggested that activation of ER-resident caspase-12 indirectly activates cytoplasmic caspases-3 and might be important in ER stress-induced neuronal apoptosis.

239 citations


Journal ArticleDOI
TL;DR: Results showed not only that levels of activity in exposed animals were higher than those in control animals, but the degree to which the activity was increased was related to the strength of the behavioral evidence for tinnitus.

228 citations


Journal ArticleDOI
TL;DR: 5-HTT genetic variation was associated with symptom severity and amygdala excitability in social phobia and individuals with one or two copies of the short allele exhibited significantly increased levels of anxiety-related traits, state anxiety, and enhanced right amygdala responding to anxiety provocation.

Journal ArticleDOI
TL;DR: The MIA model of OA is reproducible and mimics OA pain in humans, and analgesic drug studies indicate this model may be useful for investigating chronic nociceptive pain.

Journal ArticleDOI
TL;DR: It is concluded that Sox-2 might, in combination with appropriate cell-specific markers, constitute a useful marker to study the in vivo dynamics of the neural progenitor cell compartment also in the adult brain.

Journal ArticleDOI
TL;DR: Exercise was shown to modulate BDNF induction in a time-dependent manner, and this may translate to improvements in neurotrophin-mediated tasks within the CNS.

Journal ArticleDOI
TL;DR: The role of coupling between prefrontal and temporo-parietal brain areas within the theta frequency range of the human electroencephalogram was explored and results support the idea of working memory functions being dependent on distributed prefrontal-temporal networks.

Journal ArticleDOI
TL;DR: Results warrant interest for the variants of genes pertaining to the molecular clock as possible endophenotypes of bipolar disorder, and for GSK3-beta as a target of a new class of antidepressant drugs, but caution ought to be taken in interpreting these preliminary results.

Journal ArticleDOI
TL;DR: It is shown that D-methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA), D-amphetamine, and p-chloroamphetamine, each of which has been linked to dopamine (DA) or serotonin nerve terminal damage, result in microglial activation in the striatum.

Journal ArticleDOI
TL;DR: The results presented here provide the first evidence of a neuroprotective effect of Astragaloside IV in the model of ischemic brain injury and suggest that the anti-infarction effect by Astranaceus may be derived at least in part from its antioxidant properties.

Journal ArticleDOI
TL;DR: Findings provide evidence that in CRPS I pain perception can be modulated by repetitive motor cortex stimulation, and sham rTMS did not alter pain perception.

Journal ArticleDOI
TL;DR: The significant decrease in PSH, CSH and NPSSC, as well as the increase in PSSP, NPSSR, lipid peroxidation and protein oxidation levels after PTZ-induced seizure indicate increased oxidative damage in hippocampus, although the levels of GSH and GSSG do not change significantly.

Journal ArticleDOI
TL;DR: These findings indicate that after about a month in vitro these cultured neuronal networks have developed a degree of excitability that allows almost instantaneous triggering of generalized discharges.

Journal ArticleDOI
TL;DR: The results suggest that tools do not simply 'extend' peripersonal space, but that just the tips of tools actively manipulated in extrapersonalspace are incorporated into the brain's visuotactile representations of the body and of peripERSONal space.

Journal ArticleDOI
TL;DR: The results indicate that the MA task-induced activity in the right prefrontal cortex was larger than that in the left prefrontal cortex in the subject with high HR increases, suggesting that theright prefrontal cortex activity during theMA task has a greater role in cerebral regulation of HR by virtue of decreasing parasympathetic effects or increasing sympathetic effects.

Journal ArticleDOI
TL;DR: There is emerging evidence that opioid receptor antagonists may also have prokinetic actions, reversing pathological states of gastrointestinal hypomotility that are due to overactivity of the enteric opioid system.

Journal ArticleDOI
TL;DR: Postural variations in different jaws relations were significant: in particular, the SKN multiple comparison test showed that myocentric position improved postural balance on frontal plane with respect to the other jaw positions considered.

Journal ArticleDOI
TL;DR: Results warrant interest for the variants of genes pertaining to the molecular clock as possible endophenotypes of bipolar disorder, but caution ought to be taken in interpreting these preliminary results and future replication studies must be awaited.

Journal ArticleDOI
TL;DR: The present results indicate that ghrelin inhibited luteinizing hormone (LH) secretion in vivo in prepubertal males as well as gonadectomized males and females, whereas follicle-stimulating hormone (FSH) remained unaffected.

Journal ArticleDOI
TL;DR: In the present studies the neuroprotective activity of rasagiline is blocked by ERK inhibitor, PD98059 (20 microM), suggesting the involvement of PKC-MAP kinase pathway in the neuroprotection.

Journal ArticleDOI
TL;DR: It is suggested that, at least under some circumstances, proprioceptive inflow may represent the dominant sensory input to the on-line representation of the body in space.

Journal ArticleDOI
TL;DR: The results indicate that TGF-alpha may be successfully used in the bFGF induction protocol and yield higher numbers of dopaminergic neurons from hES cells.