Showing papers in "Nuclear Medicine and Biology in 2013"

TL;DR: This review seeks to provide a comprehensive portrait of the current state of ⁸⁹Zr radiochemical and imaging research, including work into the production and purification of the isotope, the synthesis of new chelators, the development of new bioconjugation strategies, and the creation of novel ⁦¬Zr-based agents for preclinical imaging studies.

TL;DR: Findings in BGLs, diabetes, insulin, and obesity affect the FDG biodistribution in muscular tissue and the brain and are therefore essential for diagnosis and follow-up of malignant diseases.

TL;DR: This review will address definitions occurring in microfluidics as well as analyze the different approaches under two macro-categories: microvessel and microchannel, involving the use of positron emitting species and fewer examples of gamma emitting radionuclides.

TL;DR: The unique biodistribution of each of these drugs may be of relevance in understanding their therapeutic and side effect profile including their teratogenic effects.

TL;DR: Results demonstrate that 5F7GGC anti-HER2 Nb labeled with residualizing [¹³¹I]IB-Mal-D-GEEEK had better tumor targeting properties compared to the directly labeled Nb suggesting the potential utility of this Nb conjugate for SPECT (¹²⁹I) and PET imaging of patients with HER2-expressing tumors.

TL;DR: It is concluded that ⁶⁸Ga-TRAP(RGD)₃ could allow for imaging of low-level integrin expression in tissues which are not visible with the two competitors, and constitutes proof of concept for the favourable in vivo properties of TRAP-based ₸Ga radiopharmaceuticals.

TL;DR: The advantages and disadvantages for broader uses of some of the well known therapeutic radionuclides are described and radioisotopes which are expected to have the potential to meet the growing demand of therapeutic Radionuclide therapy are also discussed.

TL;DR: Based on the analysis provided in this review, it appears that some proven separation technologies can be quickly resurrected for the separation of clinical grade (99m)Tc from macroscopic levels of reactor or cyclotron irradiated molybdenum targets.

TL;DR: The relatively high, time- and tumor type dependent (64)Cu uptake demonstrated here in five different human cancer xenograft models in mice, indicates that high in vivo stability of copper-based PET tracers is of particular importance because non-tracer-bound copper can accumulate in tumor tissue to a level that could potentially lead to misinterpretation of PET data.

TL;DR: Combined in vitro and in vivo data demonstrate that verapamil, in nanomolar concentrations, is selectively transported by Pgp and not by MRP1 and BCRP at the BBB, which supports the use of (R)-[11C]verAPamil or racemic [11C]-verapamIL as PET tracers of cerebral Pgp function.

TL;DR: Copper-free, strain-promoted click chemistry is an attractive, straightforward approach to radiolabeling of an α(v)β(6) integrin targeting peptide via strain- Promoted click using a fluorine-18 prosthetic group and in vitro and in vivo evaluation.

TL;DR: The potential of (89)Zr-DFO-panitumumab PET/CT imaging and non-invasive, in vivo imaging of HER1 expression and estimated human dosimetry is evaluated and it is suggested that only a low dose is expected to be clinically feasible.

TL;DR: This work is the first to use production levels of (18)F-activity to directly label RGD at specific activities that are an order of magnitude higher than most reports and thereby increases the distribution window for radiotracer production and delivery.

TL;DR: The results show the feasibility of generating radioimmunoconjugates and peptide conjugates for use as in vivo α generator systems in the clinic.

TL;DR: A systematic study on (68)Ga complexes with different bifunctional chelators (BFCs) and the effect of metal ion impurities on the radiochemical yields in order to identify the most suitable BFC to be used for the development of ( 68)Ga-based target specific radiopharmaceuticals.

TL;DR: The low reactivity of the studied cyclooctynes, and their serum interactions preclude their use at the low in vivo concentrations typical for pretargeting applications.

TL;DR: It is demonstrated that (18)F-FBPA was predominantly transported by system L in human glioblastoma cells compared to (14)C-MET, and is suitable for the selection of patients who benefit from BNCT with BPA.

TL;DR: Anti-FACBC has higher affinity for ASCT2 than for SNAT2, LAT1, or LAT2, which could be used for more effective prostate cancer imaging.

TL;DR: A robust, reliable, compact microreactor capable of chelating radiometals with common chelates has been developed and validated and outperforms conventional radiosynthetic methods for the radiometal labeling of commonly utilized BFC-BM in aqueous solutions.

TL;DR: The first (18)F-labeled uPAR PET ligand has successfully been prepared and effectively visualized noninvasively uPAR positive prostate cancer and the favorable in vivo kinetics and easy production method facilitate its future clinical translation for identification of prostate cancer patients with an invasive phenotype and poor prognosis.

TL;DR: The results of the in vitro and in vivo studies indicate that 3p-C-NETA is a promising chelator for RIT applications using (212)Bi and (213)Bi.

TL;DR: Although further studies are required to assess their performance in tumor models, the results obtained suggest that these ligands could be useful both in imaging and therapeutic treatment of bone metastases.

TL;DR: This study tested the hypothesis whether a (64)Cu-labeled NODAGA-exendin-4 peptide with a MAL linkage could decrease kidney radioactivity levels in rats, compared to a ([(64) Cu]NODAGa-MAL-exendingin- 4 reference, without impairing the radioactive levels in the target tissue.

TL;DR: A highly efficient tumor-targeting PET/fluorescence imaging probe PC-1001 is synthesized and validated in vitro in MCF-7 breast cancer cells and in vivo in mice breast cancer xenograft model.

TL;DR: Due to its relatively high tumor uptake, renal elimination and negligible abdominal localization, the new (99m)Tc-RGD peptide is considered promising in the field of imaging α(ν)β(3)-positive tumors.

TL;DR: While the radioconjugated aptamer bound specifically to the HER2 receptor on cells in vitro, it did not show any significant tumor- to-blood or tumor-to-muscle ratios in mice and modifications to radiolabeled aptamer will require improving its pharmacokinetic properties and tumor uptake in vivo.

TL;DR: Tumor PET imaging using Lactosome as a nanocarrier may be a potential candidate for a facile and general solid tumor imaging technique.

TL;DR: In the following most of the events are covered that could jeopardize the development of the drug, focusing on the industrial, economic and regulatory aspects, comprehending the detailed analysis of the currently best available radionuclides.

TL;DR: In vivo targeting fungal ribosomal RNA with (99m)Tc labeled MORF probes AGEN and AFUM may be useful for A. fumigatus infection imaging and may provide a new strategy for the noninvasive diagnosis of invasive aspergillosis and other fungal infections.

TL;DR: Based on triphenyltetrazolium chloride staining and autoradiograph image data, the hotspot uptake may be associated primarily with the ischemic penumbra, in which high apoptotic activity was observed by cleaved caspase-3 immunocytochemical staining.