Showing papers in "Nuclear Medicine and Biology in 2021"

TL;DR: The arsenal of technetium-99m radiopharmaceuticals is already equipped with imaging agents that may complement and integrate the role played by analogous tracers developed for positron emission tomography (PET), and these include, in particular, somatostatin and prostate-specific membrane antigen receptor targeting agents, and a number of peptide-derived radiopharms.

TL;DR: FES was the first PET probe for a receptor in cancer, and its development and clinical applications in breast cancer parallel the conceptual evolution of the whole field of receptor-binding radiotracers.

TL;DR: The present review addresses the availability of suitable Auger-emitting radionuclides for therapy and the design of targeting vectors which can deliver Auger emitters into/close to the nucleus by defining important parameters for the selection of radions for application to Targeted Auger Therapy.

TL;DR: Radiochemical conversion is an important term to be included in the "Consensus nomenclature rules for radiopharmaceutical chemistry" to define reaction efficiency by measuring the transformation of components in a crude reaction mixture at a given time.

TL;DR: In this article, a review of the current knowledge on uptake mechanisms of PSMA-targeting compounds in the salivary glands and the research performed to investigate different strategies to prevent or treat saliver gland toxicity is presented.

TL;DR: This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging and argues that the number of 11C-carbonyl compounds entering biological investigations should be higher.

TL;DR: In this article, a review of the current methodologies for the production and purification of 211At, both by the direct production route noted above and via a 211Rn generator system, is discussed.

TL;DR: This review will discuss the production, purification, labeling reactions, and biological studies of actinium-225 and thorium-227 complexes and clinical studies within the area of targeted alpha therapy.

TL;DR: This review summarizes the basic knowledge on [18F]FET and its contribution to the care of patients with brain tumors and its utility in tumor grading and prognostication regarding the revised WHO classification of brain tumors are addressed.

TL;DR: In this article, the authors evaluated the renal protection potential of current and promising future strategies and discussed the importance of renal dosimetry in PRRT with [177Lu]Lu-DOTA-TATE for the treatment of GEP-NETs.

TL;DR: The potential of non-destructive in-vivo imaging with positron-emission-tomography directs the view on further areas of life sciences, as exploiting the excellent methodology for basic research on molecular biochemical functions and processes is increasingly encouraged.

TL;DR: These studies proved the practicality of [18F]BODIPY dyes as a hybrid PET/optical imaging probe and recent advances in the synthesis and biological evaluation of 18F-labelled BODIPy dyes are described.

TL;DR: This work proposed an approach to liberate a radiometabolite of urinary excretion from covalently conjugated antibody Fab fragments, used as a representative LMW polypeptide, by the action of enzymes present on the brush border membrane of renal tubules.

TL;DR: A brief summary of the present status of immuno-PET, and then further development of advanced technologies related to Immuno- PET, peptidic PET probes, and nucleic acids PET probes are described.

TL;DR: In this paper, the authors provide some perspectives of using the TRIUMF ISOL facility (ISAC) to produce medical radionuclides for targeted radiation therapy application and highlight the current effort to collect of 165Er and 155Tb for Auger Therapy and SPECT imaging, respectively.

TL;DR: A site-specific strategy utilizing a radioiodinated, residualizing maleimido moiety and the anti-HER2 sdAb 5F7 bearing a GGC tail for conjugation is evaluated and may facilitate clinical translation, particularly for sdAb with compromised affinity after random labeling.

TL;DR: The role of microbiome-gut-brain axis in health and disease is described and the imaging modalities and agents that could be applied to study the dynamic interactions between microbiome, gut and brain are discussed, key aspects in understanding the biochemical lexicon underpinning the microbiome-host crosstalk that would enable the development of diagnostics and therapeutics.

TL;DR: The in vitro and ex vivo biological characterization of 18F-labeled PPQ derivatives revealed that these tracers were selective for tau in AD brain sections without off-target binding, and they furthermore demonstrated brain uptake in normal mice.

TL;DR: This manuscript will review the production routes, separation chemistry, radiolabeling techniques and in vitro/in vivo studies of three medically relevant isotopes of arsenic (arsenic-74, arsenic-72, and arsenic-77).

TL;DR: The Auger effect is based on the emission of a low energy electron (typically <25 keV) from an atom post electron capture (EC), internal conversion (IC), or incident X-rays excitation.

TL;DR: In vivo pharmacokinetics envisaged in the present design was achieved using the present gold functionalized NP preparation, which showed affinity towards FR positive KB cancer cell lines.

TL;DR: The first examples of making [11C]cyanide for radiolabeling date back to the 1960s and during the ensuing decades, it was popular for producing biologically important molecules including 11C-labeled α-amino acids, sugars and neurotransmitters as mentioned in this paper.

TL;DR: Combination radionuclide therapy (CRT) is a newer application of the concept, utilizing a combination of radiolabeled molecular targeting agents with chemotherapy and beam radiation therapy for enhanced therapeutic index as mentioned in this paper.

TL;DR: A review of recent therapeutic strategies for metastatic castration resistant prostate cancer (mCRPC) highlighting the need for rational combination of treatment options is presented in this article, where checkpoint inhibition, checkpoint inhibition as well as sipuleucel-T and PROSTVAC demonstrated only limited efficacy in mCRPC when used as monotherapy.

TL;DR: In this paper, a plasmid pBR322 assay was carried out to determine the DNA damaging properties of [201Tl]Tl(III) and a range of oxidising agents (ozone, oxygen, hydrogen peroxide, chloramine-T, iodogen, iodobeads, trichloroisocyanuric acid) were assessed using thin layer chromatography.

TL;DR: In this paper, the authors evaluated radiolabeling properties of the novel bifunctional AAZTA5-SA being coupled to a model antibody (bevacizumab) in comparison to DOTA-SA, DTPA-p-Bn-SA and CHX-A″-DTPA-mAb using the therapeutic lutetium-177.

TL;DR: The performance of the improved method for synthesizing [11C]phosgene using a carbon tetrachloride detection tube kit in environmental air analysis and the automated synthesis system for preparing [11 C]phOSgene have been reported, including automated synthesis apparatus developed in house, are reported.

TL;DR: In this article, the maximum target-to-background ratio (TBRmax) was used to diagnose high grade gliomas and brain metastases using [99mTc]Tc-iPSMA SPECT images.

TL;DR: It is hypothesized that selectivity of compound 1 for CAA is attributable to its limited penetration of the blood-brain barrier due to the highly polar nature of the carboxylate moiety, thereby limiting access to parenchymal plaques and promoting selective in-vivo labeling of Aβ deposits in the vascular wall.

TL;DR: In this article, the prostate specific membrane antigen (PSMA) and the gastrin-releasing peptide receptor (GRPR) are overexpressed in prostate cancer (PCa).