official journal of the Hungarian Association of Psychopharmacology 

About: official journal of the Hungarian Association of Psychopharmacology is an academic journal. The journal publishes majorly in the area(s): Poison control & Anxiety. Over the lifetime, 264 publications have been published receiving 5836 citations.

About the history of sexuality.

Abstract: About 50 years of demolition work, it's time now for a return to the grand syntheses. Two of the great syntheses of the 19th century have now been shattered. Marxism lies in fragments. And psychoanalysis has largely drifted outside of psychiatry to find a new and doubtless temporary home in departments of literary studies. To be sure, the third of the great syntheses, Darwin's theory of evolution, remains intact. But otherwise, as far as the eye can see, there is rubble. The time for new attempts at synthesis is now nigh. After decades of pioneering work in the neurosciences, the fundamental importance of brain biology in the human condition has now become evident. Surely one of the new syntheses will draw upon neurochemistry and neurophysiology, and it is to the great credit of the Hungarian neurosciences that pharmacologist Joseph Knoll has now ventured a first attempt. This attempt will be widely discussed and will form the platform for other work that may end up building firm bridges between "neuroenhancers" and behavior - and, what's more, to show how this relationship has shaped the evolution of thousands of years of human destiny, a great synthesis indeed.

Gender differences in suicidal behavior

Abstract: Gender-specific differences in suicidal behaviour have been analysed in a number of recent studies. According to these, several socioeconomic, demographic, psychiatric, familial, help-seeking differences can be identified in protective and risk factors between males and females. Gender is one of the most replicated predictors for suicide. In the framework of the WHO/EURO Multicentre Study on Suicidal Behaviour, more than fifty thousand suicide attempts have been registered so far. Until now data on more than 1200 monitored suicidal events have been collected in Pecs centre. In most countries male suicid rates are higher. In contrast to suicides, rates of suicide attempts are usually higher in females. Concerning the differences in methods, it is a recognised fact that males use violent methods of both suicide and attempted suicide more often than females. The summarised clinical impression suggests that compliance of male patients is poorer than that of females. According to our data, a typical male attempter is characterised as follows: unemployed, never married, lives alone. He tends to use violent methods; if he takes drugs, it is mostly meprobamate or carbamazepine. A lot of male attempters have alcohol problems or dependence. As for the females, we found high odds ratios in the following cases: divorced or widowed, economically inactive, depressive state in the anamnesis. Female attempters are mainly repeaters using the method of self-poisoning, mostly with benzodiazepines. As suicide is a multicausal phenomenon, its therapy and prevention should also be complex and gender differences should be taken into account in building up our helping strategies.

Psychometric properties of the Hungarian version of the original and the short form of the Positive and Negative Affect Schedule (PANAS).

Abstract: AIM Psychometric properties of the Hungarian version of the original and the short form of the Positive and Negative Affect Schedule (PANAS) were investigated in the present study. METHODS Participants were undergraduate university students (N=1163) and patients visiting their General Practitioners (GPs) for various somatic complaints (N=466). RESULTS According to the confirmatory factor analysis, both versions showed adequate fit to the theoretical one-and-one (positive and negative affect) factor model. Internal consistency coefficients (Cronbach-alpha values) were above .8 for the original positive and negative scales, .73 and .79 for the short positive scale, and .65 and .67 for the short negative scale in the student and the patient groups, respectively. The correlations between the original 10-item subscales and their 5-item counterparts were above .9 in both groups. CONCLUSION The short PANAS scale represents a good and practical alternative for the original version, with lower but still acceptable internal consistency values.

Suicide in schizophrenia.

Abstract: It is known that 9-13% of individuals with a diagnosis of schizophrenia commits suicide. In addition, patients with schizophrenia have approximately a 50% lifetime risk for attempting suicide. The authors review the identified risk factors for suicide in schizophrenia. The most significant risk factors include the age of the patient, male gender, depression, presence of positive symptoms and substance abuse. There is evidence that implicates the serotonin system in the suicide of individuals with schizophrenia. Overactivity of the hypothalamo-pituitary-adrenal axis has also been reported in individuals who went on to attempt suicide. The authors review the molecular biology of suicide in schizophrenia. With regard to prevention of suicide, pharmacological intervention with typical antipsychotics and antidepressants may be helpful. It is suggested that atypical anti-psychotics, in particular clozapine may provide additional benefit in reducing the rate of suicide attempts. The authors emphasise the importance of early treatment of individuals with a diagnosis of schizophrenia, the role of maintenance therapy and the importance of a collaborative approach between in- and outpatient services.

The role of purinergic signaling in depressive disorders.

Abstract: The purinergic signaling system consists of transporters, enzymes and receptors responsible for the synthesis, release, action and extracellular inactivation of adenosine 5'-triphosphate (ATP) and its extracellular breakdown product adenosine. The actions of ATP are mediated ionotropic P2X and metabotropic P2Y receptor subfamilies, whilst the actions of adenosine are mediated by P1 adenosine receptors. Purinergic signaling pathways are widely expressed in the central nervous system (CNS) and participate in its normal and pathological functions. Among P2X receptors, the P2X7 receptor (P2rx7) has received considerable interest in both basic and clinical neuropsychiatric research because of its profound effects in animal CNS pathology and its potential involvement as a susceptibility gene in mood disorders. Although genetic findings were not always consistently replicated, several studies demonstrated that single nucleotide polymorphisms (SNPs) in the human P2X7 gene (P2RX7) show significant association with major depressive disorder and bipolar disorder. Animal studies revealed that the genetic knock-down or pharmacological antagonism leads to reduced depressive-like behavior, attenuated response in mania-model and alterations in stress reactivity. A potential mechanism of P2rx7 activation on mood related behavior is increased glutamate release, activation of extrasynaptic NMDA receptors and subsequent enduring changes in neuroplasticity. In addition, dysregulation of monoaminergic transmission and HPA axis reactivity could also contribute to the observed changes in behavior. Besides P2rx7, the inhibition of adenosine A1 and A2A receptors also mediate antidepressant-like effects in animal experiments. In conclusion, despite contradictions between existing data, these findings point to the therapeutic potential of the purinergic signaling system in mood disorders.