Showing papers in "Ophthalmology in 2011"

TL;DR: Ranibizumab monotherapy and combined with laser provided superior visual acuity gain over standard laser in patients with visual impairment due to DME and had a safety profile in DME similar to that in age-related macular degeneration.

TL;DR: The age-adjusted incidence of uveal melanoma has remained unchanged from 1973 to 2008 and despite a shift toward more conservative treatments, survival has not improved during this time period.

TL;DR: Among patients with macular edema owing to BRVO or CRVO, single and repeated treatment with DEX implant had a favorable safety profile over 12 months.

TL;DR: Intraocular injections of ranibizumab provide an effective treatment for macular edema after central retinal vein occlusion, with low rates of ocular and nonocular safety events.

TL;DR: It is hypothesized that the optic nerve and ocular changes discovered in 7 astronauts after long-duration space flight may result from cephalad fluid shifts brought about by prolonged microgravity exposure.

TL;DR: This study demonstrates thickening of choroid in the eyes with PCV, in contrast with choroidal thinning observed in eyes with AMD, and suggest involvement of different pathogenic mechanisms in PCV from those in exudative AMD.

TL;DR: The expanded 2-year results reported are similar to results published previously and reinforce the conclusions originally reported: Ranibizumab should be considered for patients with DME and characteristics similar to those of the cohort in this clinical trial, including vision impairment with D ME involving the center of the macula.

TL;DR: Postoperative data indicate that DALK is superior to PK for preservation of ECD, and DALK has important theoretic safety advantages, and it is a good option for visual rehabilitation of corneal disease in patients whose endothelium is not compromised.

TL;DR: Individuals with myopia have an increased risk of developing open-angle glaucoma and study-specific odds ratios were pooled using a random effects model to determine this association.

TL;DR: Pressure reduction on fewer medications was clinically and statistically significantly better 1 year after stent plus cataract surgery versus cataracts surgery alone, with an overall safety profile similar to that of catarACT surgery alone.

TL;DR: Visual acuity in SUSTAIN patients with individualized re-treatment based on VA/optical coherence tomography assessment reached on average a maximum after the first 3 monthly injections, decreased slightly under PRN during the next 2 to 3 months, and was then sustained throughout the treatment period.

TL;DR: In the per-protocol population (293 patients), BCVA, measured by Early Treatment Diabetic Retinopathy Study-like charts, increased from baseline to month 12 by 4.9, and at month 12, BCVA gain in the monthly regimen was higher than that of the quarterly regimens.

TL;DR: DMEK had better visual acuity results in the first year after surgery than typically reported for other endothelial keratoplasty techniques, while having less refractive changes and similar endothelial cell counts but a higher rebubbling rate.

TL;DR: Both implants were effective in reducing IOP and the need for glaucoma medications and the Baerveldt group had a lower failure rate and a lower IOP on fewer medications than the Ahmed group, but had a small risk of hypotony that was not seen in the Ahmed Group.

TL;DR: The data suggest that sustained myopic defocus, even when presented to the retina simultaneously with a clear image, can act to slow myopia progression without compromising visual function.

TL;DR: Both low- and high-dose FA inserts significantly improved BCVA in patients with DME over 2 years, and the risk-to-benefit ratio was superior for the low-dose insert.

TL;DR: A structural grading system for foveal hypoplasia was developed based on the stage at which fovean development was arrested, which helps to provide a prognostic indicator for VA and is applicable in a range of disorders associated with fovea.

TL;DR: The LV, which represents the anterior portion of the lens, is a novel parameter independently associated with angle closure after adjusting for age, gender, ACD, and LT.

TL;DR: Cirrus HD-OCT ONH parameters are able to discriminate between normal eyes and eyes with glaucoma or even mild glaucolysis, and area under receiver operating characteristic curves (AUCs) are no difference.

TL;DR: The prevalences of POAG and POAG with an IOP ≤ 21 mmHg in the Namil-myon region of central South Korea were higher than that in most previous reports worldwide, but were similar to the reported rates in black and Japanese populations.

TL;DR: In each treatment group, mean visual acuity improved over 24 months, with neither approach superior to a degree detectable with the study's power, suggesting that the specific advantages and disadvantages identified should dictate selection between the alternative treatments in consideration of individual patients' particular circumstances.

TL;DR: Eye care providers need to assess patient adherence and to work with those patients with poor adherence to find ways to improve their ability and self-efficacy in using their glaucoma medications.

TL;DR: Intravitreal VEGF Trap-Eye produced a statistically significant and clinically relevant improvement in visual acuity when compared with macular laser photocoagulation in patients with DME.

TL;DR: The results support considering more aggressive treatment when undue elevation or variation in IOP measures is observed, and in models predicting inadequate IOP control, consistently significant predictors of higher maximum, standard deviation, and range of IOP included black race, higher baseline IOP, and clinical center.

TL;DR: The 5-year graft survival rates for DSEK were similar to those reported for penetrating keratoplasty in the multicenter Cornea Donor Study and the 5- year endothelial cell density was correlated weakly with the baseline donor ECD and was not significantly correlated with recipient gender.

TL;DR: Retinal arteriolar tortuosity was associated with older age and higher levels of blood pressure and BMI, whereas venular tortuose was also associated with lower HDL level, and the quantitative assessment of retinal vascular tortUosity from retinal images may provide further information regarding effects of cardiovascular risk factors on the retinal vasculature.

TL;DR: Vision loss after 2 years of monthly ranibizumab therapy was associated with lesion characteristics commonly associated with suppressed CNV, such as pigmentary abnormalities, atrophic scar, and the absence of leakage.

TL;DR: Age, axial length, CCT, and diastolic ocular perfusion pressure are significantly associated with choroidal thickness in glaucoma suspects and glau coma patients.

TL;DR: Among a Japanese cohort, DED leading to a clinical diagnosis or severe symptoms is prevalent and is more prevalent in men with low BMI, HT, and in women with myocardial infarction or angina and VDT use.

TL;DR: The SD-OCT fundus image can be used to visualize and quantify GA and has the convenience and assurance of using a single imaging technique that permits simultaneous visualization of GA along with the loss of photoreceptors and the retinal pigment epithelium that should correlate with the lost visual function.