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Showing papers in "Oral Oncology in 2001"


Journal ArticleDOI
TL;DR: Much work is required to understand the caveats related to global demography, risk factors and their diagnostic and prognostic markers for this disease which might be considered a disease distinct from that occurring in older patients.

532 citations


Journal ArticleDOI
TL;DR: It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.

382 citations


Journal ArticleDOI
TL;DR: Results indicated that the expression of snail has a key role for the acquisition of more invasive and metastatic phenotypes of SCC and the clones reported here will be useful tools for understanding the mechanism of the transition from epithelial to mesenchymal SCC cells.

217 citations


Journal ArticleDOI
TL;DR: It is suggested that with the use of parotid-sparing RT, contralateral glands are preserved at 1 year post-RT with a concomitant improvement in xerostomia-related quality of life.

208 citations


Journal ArticleDOI
TL;DR: Poor dental status was shown to lead to an approximately twofold increase in salivary acetaldehyde production from ethanol (P=0.02), which could be an important factor underlying the role of poor dental hygiene and status in oral cancer risk associated with ethanol drinking.

180 citations


Journal ArticleDOI
TL;DR: The present profile of the peripheral ameloblastoma (PA) is based on a literature survey of 160 published tumour cases and it is discussed whether PA is a true neoplastic counterpart of the IA or rather an odontogenic hamartomatous lesion.

162 citations


Journal ArticleDOI
TL;DR: It is suggested that polymorphism in CYP1A1 m2 gene and/or GSTM1 and GSTT1 null genotype may confer an increased risk for oral cancer.

156 citations


Journal ArticleDOI
TL;DR: Clinical guidelines in evaluating the possible risk of transformation in OLP lesions are illustrated to illustrate the remarkable improvement in prognosis compared to the previous study, in which the criteria were adopted different.

155 citations


Journal ArticleDOI
TL;DR: This update attempts to include and highlight some studies conducted in the Asia-Pacific region on ethnic differences and socio-cultural risk factors in relation to oral precancer and cancer.

122 citations


Journal ArticleDOI
TL;DR: It was observed that the delay in beginning oncologic treatment influenced the prognosis of the patients and the natural evolution of a head and neck cancer was progressively faster, from an initial clinical stage to an advanced clinical stage until it becomes untreatable.

114 citations


Journal ArticleDOI
TL;DR: Oral and periodontal care must continue following cancer therapy, and requires that the health care provider have an understanding of the malignant disease, oral manifestations of the disease, medical management of the Disease, and of the oral complications that may develop.

Journal ArticleDOI
TL;DR: The most striking feature separating the DA from IA is to be found in the tumour stroma: in DA there is extensive stromal desmoplasia with an abundance of thick collagen fibres that seem to compress the epithelial islands.

Journal ArticleDOI
TL;DR: 87.5% of the samples harbored at least one of the alterations in the p14(ARF), p15(INK4B), and p16(inks4A) genes, indicating that the frequent inactivation of these genes may be an important mechanism during OSCC development.

Journal ArticleDOI
TL;DR: The results indicated that the proliferating activities of ameloblastomas are quite variable, and the evaluations of Ki-67 and PCNA seem to be good indicators to assess the proliferates activity of each type of amaloblastoma.

Journal ArticleDOI
TL;DR: Oral cancer mortality in São Paulo remained stationary at high levels during the study period, but the increase of death rates related to unspecified parts of the mouth points to the deficiencies of health services in detecting most of oral cancer cases early.

Journal ArticleDOI
TL;DR: The current advances in understanding of the roles of somatic mutations, viral infection and angiogenesis are discussed and the way in which molecular changes may be used for prevention, early diagnosis and treatment of SCCHN is focused on.

Journal ArticleDOI
TL;DR: The results indicate that there was an overexpression of BMP-2/4, B MP-5, bBMP-McAb and BMPR-IA in the high-risk premalignant and malignant lesions of oral epithelium.

Journal ArticleDOI
TL;DR: The occurrence of the p53 gene alteration is less frequent in ACC and MEC than that in other kinds of tumors, and therefore does not seem to play a critical role in the course of the tumorigenesis in ACCand MEC.

Journal ArticleDOI
TL;DR: The findings indicate that having traditional herbal medication before HCP consultation increased the risk of advanced stage disease and the lower risk ofAdvanced stage OSCC associated with ulcerative tumours and those on the floor of the mouth may be due to their being more readily detected by the patients.

Journal ArticleDOI
TL;DR: The genetic defects associated with inherited cancer syndromes and their relevance to oral cancer are examined to suggest that genetic instability is of fundamental importance in the pathogenesis of oral cancer.

Journal ArticleDOI
TL;DR: A health education campaign about OSCC and the use of traditional herbal medication is recommended to shorten patient delay and continuing education on oral cancer and precancer for HCPs is needed to effect a major reduction in professional delay.

Journal ArticleDOI
TL;DR: It is concluded that amplification of the cyclin D1 gene is frequent in OED and that duplex, quantitative polymerase chain reaction is a reliable method to detect this change in routinely processed biopsies and suggests that this method may be suitable to assess cyclinD1 gene status in tissues not suitable for protein analysis.

Journal ArticleDOI
TL;DR: A case-control study of OC in Athens obtained information on tobacco, alcohol use and other potential risk factors and confounding variables for 110 incident cases and 115 hospital-based controls, and the type of alcoholic beverage seemed important: drinking ouzo and tsipouro was associated with greater increased OC risk than drinking comparable amounts of wine, beer or dark spirits.

Journal ArticleDOI
TL;DR: Data suggest that the c1 allele may contribute to increased risk for oral cancer in Caucasians and African Americans.

Journal ArticleDOI
TL;DR: The results of this single dose trial suggest that topical doxepin rinse has significant ability to provide clinically significant pain relief in patients with mucosal damage with an extended duration of effect.

Journal ArticleDOI
TL;DR: Investigation of differentiation-specific keratins in oral epithelial dysplasia and squamous cell carcinoma revealed an essentially normal pattern of keratin gene expression, which reflects the gross changes in epithelial differentiation and maturation.

Journal ArticleDOI
TL;DR: The case of an osteolipoma of the tongue in a 49-year-old female who was referred for a painless mass on the left lateral margin of the tongues, and present for about 8 years, is presented.

Journal ArticleDOI
TL;DR: The results showed that although treatment guided by clinical removal of leukoplakia reduced cancer progression risk in all three risk groups, the amount of reduction in the study group did not reach statistical significance, and suggest the use of molecular profiles to guide the treatment of low-grade dysplasia.

Journal ArticleDOI
TL;DR: It is suggested that smoking and alcohol drinking have different patterns of associated variables in post-therapeutic H&N cancer patients, which has important implications for intervention design.

Journal ArticleDOI
TL;DR: It is established that osteosarcoma of bone is not a stereotyped disease, and several varieties have been identified by clinical findings, radiographic and histopathologic appearances, but the aetiology and precise pathogenesis of this disease remain unknown.