Showing papers in "Oral Oncology in 2009"

TL;DR: This review presents data on incidence, mortality, survival and trends in cancers of the lip, oral cavity and oropharynx using available recent data sources around the world to gain insight into the geographic variations in the incidence of this cancer in the globe.

TL;DR: At present, oral lichen planus seems to be accepted in the literature as being a potentially malignant disorder, although the risk of malignant transformation is lower than in leukoplakia, and the efficacy of follow-up of oral lichens planus is questionable.

TL;DR: The role of the surgeon is essential throughout the life history of a patient with a malignant neoplasm in the head and neck area, from initial diagnosis through definitive treatment, post-treatment surveillance, management of complications, rehabilitation of the sequelae of treatment, and finally for palliation of symptoms.

TL;DR: The WHO Global Oral Health Programme is committed to work for country capacity building in oral cancer prevention, inter-country exchange of information and experiences from integrated approaches in prevention and health promotion, and the development of global surveillance systems for oral cancer and risk factors.

TL;DR: An overview of oral squamous cell carcinoma (OSCC) is presented highlighting essential points from the contributors to this issue, to set the scene.

TL;DR: Current research is leading to a comprehensive understanding of the biology of mucositis, which has resulted in the development of novel interventions and a number of eclectic molecules, all designed to interfere with pathways that lead to injury are in pre-clinical and clinical development.

TL;DR: Age-sex mortality rates for the North-West indicate that 15.0% of the 489 primary surgery patients might have been expected to die within 5 years if they were typical of the general population and the observed difference between all causes and oral-cancer specific survival was 18.3%.

TL;DR: The emerging information on how the use of modern technologies and the molecular dissection of aberrant signaling networks, including the EGFR, ras, NFkappaB, Stat, Wnt/beta-catenin, TGF-beta, and PI3K-AKT-mTOR signaling pathways can help elucidate the molecular mechanisms underlying HNSCC progression is discussed.

TL;DR: Following Adler's theory and the principles of the "Ottawa Charter for Health Promotion", conditions such as education, sustainable resources, social justice, and equity must be satisfied before the implementation of physical health promotion campaigns.

TL;DR: The administration of ZA/DX preceding dental extractions in rats results in the development of bony and soft tissue changes that are similar to those noted humans who develop BRONJ, and may provide a useful model for study of its pathogenesis, as well as strategies for its prevention and treatment.

TL;DR: Odontogenic tumors are in general uncommon lesions in this Chinese population and some similarities between the data and the previous studies from Africa and Asia and some differences in comparison to the reports from American and European countries are identified.

TL;DR: In RMSGCs further evaluations of EGFR targeting agents are advisable and should take place by appropriate tumor biological selection, differentiating ACC from non-ACC.

TL;DR: The Patients Concerns Inventory (PCI) helps focus the consultation onto patient needs and promotes multidisciplinary care and is being rolled out to other consultants in the H & N clinic.

TL;DR: Recent incidence trends of HNSCC in The Netherlands vary between sites with a considerable increase of oropharyngeal cancer as the most remarkable finding; the reason for the decreasing annual incidence rate at all sites observed for Dutch young adults remains to be explained.

TL;DR: This work reports the identification, expansion, and characterization of CD44+ cancer stem-like cells from a permanent squamous cell carcinoma of the head and neck (SCCHN) cell line and indicates that a subpopulation of CSCs is maintained in the SCCHN cell line, and the presence of such C SCs has an important clinical implication for head and head cancer treatment.

TL;DR: This article looks beyond the standard protocols and deals with potential difficulties and pitfalls in the assessment of incisional biopsy specimens, surgical resection specimens and neck dissections and considers the prognostic value of accurate histopathological staging.

TL;DR: There is a plethora of conflicting data which suggest the answer to the question if microscopic evidence of perineural invasion has true prognostic significance in adenoid cystic carcinoma is indeed in the affirmative.

TL;DR: This TK-hormonal receptors analysis identify a histotype-specific profiles that could be exploited for better selecting patients for innovative treatment within prospective studies.

TL;DR: LOH, survivin, MMP 9 and DNA content are potential markers for increased risk of progression from oral dysplasia to cancer, and research into this field should concentrate on longitudinal design, with pooling of data from multiple centres to achieve larger cohorts.

TL;DR: The significance of positive margins emphasizes the need for adequate surgical resection in patients with oral verrucous carcinoma treated surgically and the presence of either leukoplakia or SMF and tumor location in the upper alveolar-palatal complex is associated with worse outcomes.

TL;DR: It is now possible to exclude a strong relation between these foods and oral and pharyngeal cancer risk, and the population attributable risk increases to 85-95% when tobacco and alcohol consumption are also considered.

TL;DR: Combined FDG-PET/CT is a useful screening method for primary tumor detection, accurate nodal staging, and distant metastases in patients with CUPs.

TL;DR: The infectious nature of OSCC in NS/ND was revealed by consistent detection of HPV, suggesting HPV's potential role in transforming oral epithelium, providing further evidence of the need to screen the oropharynx for HPV in non-smokers/non-drinkers.

TL;DR: Accumulated data are predicted to alter the field of oral cancer diagnosis by employing highly sensitive new tools which will enable both medical professionals and the patients themselves to monitor their saliva for diagnosis and prognosis prediction, as they relate to oral cancer.

TL;DR: It is concluded that aneuploid oral dysplastic lesions have a high risk of malignant progression and that DNA image cytometry might help to identify those lesions most at risk.

TL;DR: The results of this study show for the first time that overexpression of the HDAC protein is a frequent event in oral cancer and could be used as a prognostic factor in oral SCC.

TL;DR: Gyp induced ER stress and production of reactive oxygen species and Ca(2+), change the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, caused cytochrome c release, activation of caspase-3 before leading to apoptosis.

TL;DR: The impact of TIL on prognosis in patients with head and neck cancer may be affected by type of treatment and stage of disease, and this finding will influence future studies on the role of Til in human cancers.

TL;DR: It is not yet clear whether FDG-PET can reliable avoid futile routine evaluation by examination under general anaesthesia in oral and oropharyngeal cancer and planned neck dissection when a residual mass persists in the neck after (chemo)radiation.