Showing papers in "Pancreatology in 2017"

TL;DR: The working group has revised the guidelines regarding prediction of invasive carcinoma and high-grade dysplasia, surveillance, and postoperative follow-up of IPMN and includes updated information and recommendations based on the current understanding.

TL;DR: The present definition acknowledges that resectability is not just about the anatomic relationship between the tumor and vessels, but that biological and conditional dimensions are also important.

TL;DR: Gallstone is the dominant aetiology in southern Europe and alcohol in eastern Europe with intermediate ratios in northern and western Europe, and Acute pancreatitis continues to increase throughout most of Europe.

TL;DR: Assessment of pain follows the guidelines for other types of chronic pain, where the multidimensional nature of symptom presentation is taken into consideration and neurolytical interventions and neuromodulation can be considered in difficult patients.

TL;DR: This multicenter study revealed several key points concerning the diagnosis and management of early-stage PDAC, including screening of asymptomatic cases, importance of indirect imaging findings, application of cytology during endoscopic retrograde cholangiopancreatography, and the risk of carcinogenesis in the remnant pancreas.

TL;DR: Recommendations are based on the available evidence, and eastern and western experts' opinions to find standard treatment of AIP worldwide and can be tailored according to the local expertise and context in the management of individual patients.

TL;DR: This review systematically focuses on the role played by the different microenvironmental components in determining chemoresistance of pancreatic tumors.

TL;DR: Sarcopenia is independently associated with PEI in patients with pancreatic disease, and on multivariate analysis, only sarcopenia remained independently related to PEI.

TL;DR: A new taxonomy of DEP, compliant with the American Diabetes Association standards of diagnosis and care for patients with diabetes mellitus, will ensure standardisation of reporting in future clinical studies on DEP and enable a dynamic incorporation of glucose dysregulation mechanisms related specifically to diseases of the exocrine pancreas as new evidence emerges.

TL;DR: The study suggests that CP at a population level may have a milder course than that reported from tertiary centers, and confirms that ACP has a more severe phenotype than NACP.

TL;DR: A ten-year US tertiary-center experience in managing AP patients and its trends overtime is described, finding that pancreatic intervention is required in less than 50% of patients with necrotizing pancreatitis.

TL;DR: This study provides the first evidence of RFA-based immunomodulation in LAPC, and most cells showed prolonged activation some weeks after the procedure, suggesting true immunommodulation rather than a normal inflammatory response.

TL;DR: Current evidence suggests a possible link between microbiota imbalance and pancreatic cancer and acute and chronic pancreatitis, and dysbiosis appears to be present in both conditions.

TL;DR: A systematic review of the frequency and prognosis of AP associated with fulminant or non-fulminant acute hepatitis A and developed a tool for risk of bias assessment of case reports and case-series and applied to the included studies.

TL;DR: The CEL gene has proven to be exceptionally polymorphic due to copy number variants of the CEL-CELP locus and alterations involving the VNTR, and is an attractive candidate gene for further exploration of links to pancreatic disease.

TL;DR: More carers had symptoms of anxiety than patients with pancreatic cancer, but symptoms of depression were similarly common in patients and carers, and accessing psychological help was associated with elevated anxiety.

TL;DR: It is suggested that overexpression of KIAA1199 may contribute to increased migration of PDAC cells and predict shorter survival after surgical resection.

TL;DR: The Fukuoka criteria have considerably improved sensitivity but still lack adequate specificity, and the development of criteria with an increased specificity is required for further reduction of a potential surgical overtreatment of BD-IPMN.

TL;DR: In nearly 1 out of 3 patients undergone pancreas cyst surgery, there is a discrepancy between pre- and post-op diagnosis of presumed MCN, which is more likely to be incorrect than the other cysts.

TL;DR: "Step up" endoscopic transmural drainage using multiple plastic stents as an initial therapy is safe and effective treatment of WON and avoids more aggressive DEN in majority of patients.

TL;DR: A single rectal dose of NSAIDs is effective in preventing PEP both in high-risk and in unselected patients, regardless of timing of administration (pre- or post-ERCP) and NSAID type (indomethacin or diclofenac).

TL;DR: The clinical efficiency of RFA for hepatic oligometastatic pancreatic cancer was easily affected by the following factors: primary tumor location, maximum diameter of liver metastasis and NLR.

TL;DR: EOB-MR imaging was useful in detecting tiny liver metastases from pancreatic cancer in cases that were determined to be radiologically resectable by MDCT.

TL;DR: Among the three inflammatory biomarkers, NLR has the highest discriminatory capacity for severe HTG-AP, with an optimal cut-off value of 10, which is significantly higher in patients with severe AP than mild and moderately severe AP.

TL;DR: DP-CAR followed by adjuvant chemotherapy provided an acceptable overall survival rate in patients with highly advanced PDAC, but should be performed with great caution because of high morbidity.

TL;DR: Preoperative DM was associated with significantly higher risk of high-grade dysplasia and invasive carcinoma in resected IPMN, and risk of invasive carcinomas was highest in patients with recent-onset DM.

TL;DR: An algorithm based step-up approach for interventions in necrotizing pancreatitis using primarily endoscopic techniques with adjunctive percutaneous approaches as needed resulted in favorable outcomes with small numbers proceeding to open surgery, and with acceptable rates of major complications and mortality.

TL;DR: A review of genes and miRNAs involved in resistance to gemcitabine in pancreatic cancer shows that microRNAs play significant roles as key regulators of gene expression in many cellular processes, including drug resistance.

TL;DR: S-MRI provides detailed information about pancreatic morphology and function and represents a promising non-invasive imaging method to characterize pancreatic pathophysiology and may enable monitoring of disease progression in patients with CP.

TL;DR: Serum and plasma were found to be good materials for detecting cancer-specific DNA in the peripheral blood and the presence of KRAS mutations in blood-derived DNA may be used as a prognostic biomarker for patients with pancreatic cancer.