Showing papers in "Peptides in 2007"

TL;DR: The increase in OT from early to late pregnancy correlated with higher maternal-fetal bonding, and these data may help set standards for OT levels and underscore links with maternal-infant attachment.

TL;DR: This review aims to present comprehensive information of recent topics, cover new additional data, and present new perspectives on these families of peptides, subdivided into two families, which present molecular masses around 7 and 10 kDa.

TL;DR: FGF21 shows significant, non-saturable, unidirectional influx across the blood-brain barrier, and co-injection of excess FGF21 failed to inhibit the influx, showing a lack of saturation.

TL;DR: It is concluded that the permeation of nesfatin-1 is a non-saturable process in either the blood-to-brain or brain- to-blood direction, which does not limit the pharmacological delivery of this satiety peptide as a potential therapeutic agent.

TL;DR: This article reviews the present knowledge regarding VIP and PACAP receptors, i.e. VPAC1, VPAC2 and PAC1, and provides a critical description of the two models ofVPAC1 receptor activation in the general context of class II/family B G protein-coupled receptors.

TL;DR: This is the first report describing at least a part of defense peptide repertoire of G. mellonella immune hemolymph, which inhibited fungal and sensitive bacteria growth in a concentration of 2.9 and 1.9 microM.

TL;DR: It is demonstrated that nesfatin-1 crosses the BBB in both the blood-to-brain and brain- to-blood directions by nonsaturable mechanisms.

TL;DR: Good tyrosinase inhibitory peptides preferably contain arginine and/or phenylalanine in combination with valine, alanine and-or leucine, as well as the presence of the hydrophobic, aliphatic residuesValine,Alanine orLeucine appears to be important for tyosinase inhibition.

TL;DR: The peptide H-KKLFKKILKYL-NH(2) (BP100) showed efficacies in flowers of 63-76% at 100 microM, being more potent than BP76 and only less effective than streptomycin, currently used for fire blight control.

TL;DR: It is concluded that NPY/AgRP neurons are not necessary for generating or mediating the orexigenic response to glucose deficiency, but they are essential for the feeding response to ghrelin and refeeding on standard chow after a fast.

TL;DR: Apelin stimulates proliferation and suppresses serum deprivation-induced apoptosis of MC3T3-E1 cells and these actions are mediated via JNK and PI3-K/Akt signaling pathways.

TL;DR: The results indicate that PP-CCK interactions may be either antagonistic or synergistic and the transgenic mice may exhibit the mixed phenotype by overproduction of PP and CCK.

TL;DR: Recently, it was proposed that Cyt1Aa synergizes or suppresses resistance to Cry toxins by functioning as a membrane-bound receptor for Cry toxin.

TL;DR: An antifungal protein, with a molecular mass of 41.9 kDa, and designated as bacisubin, was isolated from a culture of Bacillus subtilis strain B-916 and demonstrated neither protease activity, nor protease inhibitory activity, however, it manifested ribonuclease and hemagglutinating activities.

TL;DR: TNF-alpha, on a dose-dependent way, modulates insulin and leptin signaling and action in the hypothalamus and partially impairs signal transduction through IRS-2, Akt, ERK and FOXO1 but not through JAK-2 and STAT-3.

TL;DR: QM/MM simulations at the DFTB/UFF level confirm the experimental NMR findings and provide detailed structural information on these compounds in aqueous solution.

TL;DR: Results demonstrate that apelin directly activated the vascular L-Arg/NOS/NO pathway, which could be one of the important mechanisms of apelin-regulated vascular function.

TL;DR: NPY receptors are novel and promising candidates in this field and may be targeted with NPY analogs coupled with adequate radionuclides or cytotoxic agents for a scintigraphic tumor imaging and/or tumor therapy.

TL;DR: It is suggested that hypothalamic leptin functions as an essential permissive factor for normal bone growth and long duration selective central leptin repletion via recombinant adeno-associated virus-leptin (rAAV-lep) gene therapy on bone in growing ob/ob mice.

TL;DR: In goldfish, ghrelin and orexin-A have interacting orexigenic effects in the central nervous system, the first report that orexIn-A-induced feeding is mediated by the Ghrelin signaling in any animal model.

TL;DR: In this review, examples of neuroprotective actions will be presented that serve to demonstrate the remarkable breadth of neuroProtective processes produced by VIP and PACAP.

TL;DR: Current knowledge and recent findings of the rapidly growing family of adipokines and their interactions with the blood-brain barrier are summarized.

TL;DR: In the aorta of SD rats, the vasodilator effect of Ang-1-7 is dependent on endothelium-derived nitric oxide, which suggests the existence of a different Ang-(1- 7) receptor subtype.

TL;DR: Observations support a role for obestatin in regulating metabolism through changes of appetite, but indicate no direct actions on glucose homeostasis or insulin secretion.

TL;DR: The importance of the C-terminal sequence LPPR and particularly the key role of C-Terminal arginine is shown, which is very flexible in the absence of NRP-1 pointing to an induced fit upon binding to the receptor.

TL;DR: NPY-Y2-DPPIV agonists may be beneficial for ischemic revascularization and wound healing, whereas antagonists may be therapeutic in retinopathy, tumors, and obesity.

TL;DR: Levels of cortisol, ACTH and CRH were determined longitudinally from the plasma of 310 African American, Hispanic and non-Hispanic White women at 18-20, 24-26 and 30-32 weeks' gestation to suggest ethnic disparities in adverse birth outcomes may be due, in part, to differences in HPA axis and placental function.

TL;DR: It seems that endogenous orexin-A and oxin-B, through DG OX1Rs, play an important role in spatial learning and memory in the rat.

TL;DR: It is demonstrated that the overall intestinal morphology and light microscopic structure is significantly altered in VIP(-/-) mice, and there is an overall increase in weight, and decrease in length of the bowel compared to wild type (WT) controls.

TL;DR: This review summarizes the current knowledge of the potential role of VIP and PACAP in islet function and suggests that activation of the receptors, in particular VPAC2 receptors, may be used as a therapeutic approach for the treatment of type 2 diabetes.