Pharmaceutical technology 

About: Pharmaceutical technology is an academic journal. The journal publishes majorly in the area(s): Outsourcing & Cleaning validation. It has an ISSN identifier of 2717-7904. Over the lifetime, 871 publications have been published receiving 12962 citations. The journal is also known as: J Pharm Technol & JPT.

Fast-dissolving tablets

Abstract: Fast-dissolving tablet technologies are important for patients who have difficulty taking conventional oral dosage forms as well as for pharmeceutical firms seeking line extensions in the marketplace. This artide describes existing fast-dissolving technologies and discusses several techniques used to formulate such tablets, namely tablet molding, freeze-drying, spray-drying, sublimation, disintegrant addition, and the use of sugar-based excipients.

On the physical characterization of pharmaceutical solids

Abstract: A general review of the methods available for the physical characterization of pharmaceutical solids is presented. The techniques are classified as being on the molecular level (properties capable of being detected in an ensemble of individual molecules), the particulate level (properties which can be detected through the analysis of an ensemble of particles), and the bulk level (properties which can be measured only using a relatively large amount of material). The molecular-level properties discussed are infrared spectroscopy and nuclear magnetic resonance spectrometry, the particulate-level properties discussed are particle morphology, particle size distribution, powder X-ray diffraction, and thermal methods of analysis, and the bulk-level properties discussed are surface area, porosity and pore size distribution, and powder flow characteristics. Full physical characterization of three modifications of lactose (hydrous, anhydrous, and Fast-Flo) is presented to illustrate the type of information which can be obtained using each of the techniques discussed.

On powder flowability

Abstract: The term powder flowability is used loosely and has generally been more closely associated to the test method used to measure it than the significance to the process. To the formulator, flowability is linked to the product. To the engineer, flowability relates to the process. Relating powder flowability results to actual behavior in the production process is the true reason flowability is measured. This article connects typical powder handling processes to flow property measurements of value to the formulator and the process engineer.

A Means to Address Regional Variability in Intestinal Drug Absorption

Abstract: The control of gastrointestinal transit of orally administered dosage forms using gastroretentive drug delivery systems (GRDDS) can improve the bioavailability of drugs that exhibit site-specific absorption. Prolonged gastric retention can be achieved by using floating swelling, bioadhesive, or high-density systems. This article reviews the concept of the absorption window and describes the performance evaluation of GRDDS, including in vitro-in vivo correlation studies and potential use.