Showing papers in "Pharmacological Reports in 2019"

TL;DR: The effect of negative childhood experiences on the central nervous system can result in many structural and functional changes of the brain, including such structures as hippocampus and amygdala, associated with the development of bipolar and depressive illnesses.

TL;DR: In this paper, the authors present properties, methods of preparation and tests to assess the quality and toxicity of nanostructured lipid carriers (NLC) for dermal and transdermal drug application.

TL;DR: The results confirmed the anti-inflammatory activity of caffeic acid and highlighted its neuroprotective activity against rotenone-induced neurodegeneration in mice.

TL;DR: The results suggest that pioglitazone may be a potential adjuvant for the treatment of Parkinson`s disease because of its effects on pathological markers of the progression of neurodegeneration.

TL;DR: It is revealed that crocin has preventive effects on the LPS induced sepsis and its cardiac toxicity in-vitro model related to anti-inflammatory and anti-oxidant properties of crocin.

TL;DR: It is found that some sulfonamides exhibit potential inhibitor properties for the human serum PON1 with IC50 values in the range of 24.10-201.10, and sulf onamides 1, 2, 4, 5, 8, and 9 showed a non-competitive inhibition effect whereas sulfOnamides 3, 6 and 7 showed competitive inhibition.

TL;DR: By way of its multikinase inhibitory effects, berberine might be a useful replacement for lapatinib, an EGFR inhibitor which can cause acquired drug resistance in patients.

TL;DR: NAR, TMZ, or their combination could attenuate the Nrf-2 expression in the kidney tissue, following the renal IR injury through inhibition of lipid peroxidase, and enhancement of antioxidant activity.

TL;DR: By increasing antioxidant defense in hepatic tissues and reducing oxidative stress and proinflammatory mediators, pretreatment with CRO could alleviate MTX-induced hepatotoxicity.

TL;DR: Overall, the clinical data compiled on phytochemicals against EC is not sufficient and need future research to provide additional insights for developing potential anticancer drugs in pharma industries.

TL;DR: It is suggested that selenium intake enhances the effect of vitamin D on thyroid autoimmunity and affects serum hormone levels, Jostel's index and the SPINA-GD index.

TL;DR: Results of the study suggested the possible utility of thiazole-1,3,5-triazines as new lead for identifying new class of Pf-DHFR inhibitor.

TL;DR: Findings indicate that fraxetin is effective in preventing liver fibrosis through inhibiting inflammation and hepatocytes apoptosis which is associated with regulating NF-κB/IκBα, MAPKs and Bcl-2/Bax signaling pathways in rats.

TL;DR: Some benzoquinazolines had good activity and had the capacity to deplete DPPH and free radicals compared to a positive control butylated hydroxyl toluene (BHT) and can be used as templates for further development of more potent antioxidative agents.

TL;DR: Th lymphocytes, in particular T helper 17 cells, contribute to the development of both autoimmune diseases and psychiatric disorders including depression, as well as have an impact on the differentiation of T CD4+ cells into Th17 cells in the later development of the child's organism, which confirms the importance of the foetal period for the progression of depressive disorders.

TL;DR: The suppression of NF-κβ-mediated inflammation, oxidative stress, and caspase-3 induced apoptosis are possible mechanisms to the observed hepatoprotective effect of betaine.

TL;DR: The present data suggest that the cholinergic system plays an important role in CCH-induced cognitive deficits and could be an effective therapeutic target for the treatment of vascular dementia.

TL;DR: The results indicate that one of the most commonly used antidiabetic drug, metformin, has the potential to prevent the development of dementia and be a novel therapeutic drug for the amelioration of cognitive dysfunction in AD.

TL;DR: 7,8-DHF could be an effective pharmacological intervention in combating HFD and EtOH-induced hepatotoxicity in rats, which was ameliorated by 5 mg/kg/day treatment.

TL;DR: Nor-wogonin significantly inhibited the growth and decreased the viability of TNBC cells; however, it exhibited no or minimal effects in non-tumorigenic breast cells, suggesting it might be a potential multi-target agent for TNBC treatment.

TL;DR: Results indicate that hepatoprotective activity of Sit against HIR is attributed at least in part to modulation of Nrf-2/ HO-1 signaling pathway.

TL;DR: L lovastatin downregulated genes that are involved in stemness and invasiveness in mammary tumors, corroborating in vitro findings and suggesting that the inhibition of HMGCR might develop new adjuvant therapeutic strategies for breast tumors.

TL;DR: Luteolin can protect against non-alcoholic steatohepatitis through targeting the pro-inflammatory IL-1 and Il-18 pathways in addition to an antioxidant effect.

TL;DR: The hypothesis that TLR-2 induced inflammation leads to insulin resistance and cognitive impairment is supported and the evidence for the therapeutic effect of ALA in IR and ADRD patients is provided.

TL;DR: The data suggest that the indolizine derivatives can be a benchmarks for designing potent oral antidiabetic agents and justify the rehabilitation and regeneration of islets, acini and Sertoli cells in animals treated with compound 12.

TL;DR: The results suggest that PINK1 depletion alters energetic metabolism and confers sensitivity to agents that inhibit glycolysis, which may prove useful in the clinical setting while sparing non-malignant tissue.

TL;DR: Sildenafil and tadalafil inhibit oxidative and nitrosative stress in animal model of bronchial asthma and could have a therapeutic potential in bronchia.

TL;DR: AS-IV inhibited palmitate-induced HMCs oxidative stress and fibrosis via the downregulation of CD36 expression, mediating FFA uptake and lipid accumulation.

TL;DR: Despite the increased antioxidant capacity in blood of Cu nanoparticle fed rats, vasoconstrictor prostanoids and NO are involved in vascular regulation.

TL;DR: Findings support the chemopreventive activity of Lf against HCC, and suggest regulation of PKB-pathway as a potential mechanism underlying this effect.