Showing papers in "Pharmacological Research in 2010"

TL;DR: There is still a room for optimisation in the area of the nanoparticle kinetics such as improving their plasma circulation and tumour bioavailability and understanding the effect of targeting ligands on their efficiency to treat cancer.

TL;DR: This review summarizes the most commonly used functionalization methods of the MNPs preparation methods and their use in targeted drug delivery and targeted therapy.

TL;DR: The human gut is populated by an array of bacterial species, which develop important metabolic and immune functions, with a marked effect on the nutritional and health status of the host.

TL;DR: Expectations regarding the effectiveness of methylphenidate and modafinil exceed their actual effects, as has been demonstrated in single- or double-blind randomised controlled trials.

TL;DR: An overview of the iron-based inorganic nanostructured materials that have been developed and tested in various fields, including biology and medicine, and the new generation of inorganic hybrid nanostructure, which are structures that integrate in each nano-object multiple in organic nanocrystals of different materials.

TL;DR: This review summarises all the scientific evidence regarding the effects of milks enriched with long chain omega-3 PUFA (EPA+DHA) and/or oleic acid on cardiovascular health.

TL;DR: The various molecular signal transduction pathways and the regulators of hypertrophic response including calcineurin, cGMP, NFAT, natriuretic peptides, histone deacetylase, IL-6 cytokine family, Gq/G11 signaling, PI3K, MAPK pathways, Na/H exchanger, RAS, polypeptide growth factors, ANP, NO, TNF-alpha, PPAR and JAK/STAT pathway are discussed

TL;DR: Aminoglycoside antibiotics are employed clinically because of their potent bactericidal activities, less bacterial resistance, post-antibiotic effects and low cost, but drugs belong to this class are well-known to cause nephrotoxicity, which limits their frequent clinical exploitation.

TL;DR: Prebiotics promote the growth of "good" bacteria and, while a variety of health benefits have been attributed to their use, prebiotics have been subjected to few large scale clinical trials.

TL;DR: Many qualitative differences of cocoa and chocolate are reviewed, aiming to establish the different implications for public health through the use of the analyzed concentration of polyphenols in cocoa products.

TL;DR: Since the action of plant sterols or stanols on plasma LDL cholesterol is additive to that of statins, the former can be used to increase the latter's hypocholesterolemic action in patients needing a marked reduction in plasma cholesterol levels.

TL;DR: Experimental studies demonstrate that dietary MCFAs/MCTs suppress fat deposition through enhanced thermogenesis and fat oxidation in animal and human subjects and several reports suggest that MCF as well as MCTs offer the therapeutic advantage of preserving insulin sensitivity in animal models and patients with type 2 diabetes.

TL;DR: This manuscript provides a forward looking assessment of the promise of nanomedicine as it pertains to individualized medicine and establishes a technology "snapshot" of the current state of nano-based products over a vast array of clinical indications and range of patient specificity.

TL;DR: This review will focus on pharmaceutical forms that are based on inorganic nanoparticles where the nanosize of the inorganic component provides unique characteristics to the pharmaceutical form.

TL;DR: The present results show that QU-ME exhibits pronounced anti-inflammatory properties in a murine model of airways allergic inflammation and suggest that it might present therapeutic potential for the airways inflammatory diseases management.

TL;DR: The role H(2)S plays in different model systems of I/R injury is described and some of the mechanisms involved with its cytoprotection are detailed.

TL;DR: This review gives an overview and assessment of the most widely sold herbal medicinal products, including liquorice, garlic, ginger, ginkgo, green tea, St. John's wort, saw palmetto, turmeric, valerian, milk thistle and echinacea, on the basis of the available scientific evidence.

TL;DR: Expectations about the potential of these drugs exceed their actual effects, as has been demonstrated in randomised controlled trials, based on a systematic review of known interventions.

TL;DR: The evidence for the emerging role of SIRT1-mediated deacetylation in the control of metabolic homeostasis is surveyed.

TL;DR: Findings, although preliminary, suggest that the CNR1 1359 G/A and the FAAH cDNA 385C to A gene variants may contribute to the susceptibility to mood disorders.

TL;DR: How opposing effects on distinct cell types may profoundly influence the overall therapeutic potential of HDAC inhibitors when investigating treatments for neurodegenerative disorders is addressed.

TL;DR: Investigation of the effect of curcumin on memory functions, brain IRs, acetylcholinesterase activity and oxidative stress in intracerebroventricular (ICV) administered streptozotocin (STZ) induced dementia in rats suggests effect on brain IR may also be an important factor for protective effect ofCurcumin against STZ induced dementia model.

TL;DR: HDACi data in hematological malignancies are reviewed, questioning the molecular basis of observed clinical responses, and highlighting some of the concerns raised on the use of these drugs for cancer therapy.

TL;DR: This review presents an overview of different non-viral delivery systems, which have been evaluated in vivo or entered in clinical trials, with a focus on their physicochemical properties in order to help the development of new and efficient siRNA Delivery systems, as the therapeutic solutions of tomorrow.

TL;DR: This review discusses viral vector-mediated gene transfer of NTFs to treat neurodegenerative diseases of the central nervous system and discusses the likely candidates for preventing Neurodegeneration and promoting neuroregeneration.

TL;DR: For all subjects combined, quercetin supplementation over 12 weeks had no significant influence on URTI rates or symptomatology compared to placebo.

TL;DR: The results suggest that the protective effects of sulforaphane against I/R injury may be partly mediated through mitochondrial K(ATP) channels and antioxidant pathway.

TL;DR: Eleven authenticated botanicals used in the traditional Chinese medicine Huo-Luo-Xiao-Ling Dan were screened for ligands to cyclooxygenase (COX) and the IC(50) values of most of these natural product ligands have not been reported previously.

TL;DR: Results indicate that pure HT transiently associates with LDL lipoproteins in vivo, and no changes were found in total antioxidant capacity, malondialdehyde or LDL lag time.

TL;DR: F multifarious molecular signaling mechanisms involved in the pathogenesis of cardiac hypertrophy are described, including tumor necrosis factor-α, Wnt/Frizzled signals, calcineurin, mitofusin-2, mitogen-activated protein kinases, Janus kinase, Rho kin enzyme, poly (ADP-ribose) polymerase, transcription factors, oxidative signals and G-protein-coupled-receptor-associated signaling system.