Showing papers in "Pharmacology & Therapeutics in 1983"

TL;DR: In experimental animals, the use of relatively larger doses of alcohol and more extreme temperatures, both above and below the thermoneutral zone, has shown that the effect of ethanol is essentially poikilothermic, i.e. an impairment of adaptation to both heat and cold.

TL;DR: The introduction and evaluation of agents possessing a specificity of pharmacological action will undoubtedly aid psychotherapeutic research and the knowledge that peptides and 'classical' neurotransmitters can co-exist in the same neurone will undoubtedly generate studies of the significance and importance of the co-transmitter function of peptides in the mechanisms of action of antidepressant therapies.

TL;DR: A controlled release system utilizes a polymer matrix or pump as a rate-controlling device to deliver the drug in a fixed, predetermined pattern for a desired time period to improve drug administration and facilitate patient compliance.

TL;DR: The physiological, pharmacological and clinical consequences of these estrogenic and antiestrogenic activities of androgens in humans are discussed in Sections 5-7.

TL;DR: 'gestational state' and 'species' dependent differences in adverse drug effects, in the presence of a constant level of exposure of drug, reflect the time dependent appearance of these processes and the differences in ontogeny of the processes among species.

TL;DR: Evidence that the phenomenon of 'recovery from potentially lethal damage' is therapeutically-exploitable is mainly lacking and the evidence that the effect is not simply an artefact of clonogenic assay procedures is scanty must be borne in mind.

TL;DR: There are many opportunities to apply therapeutic principles rationally with the potential of significant benefit to many patients using pharmacologically rational programs aimed at delivering maximal systemic chemotherapy along with regional treatment.

TL;DR: There is no evidence that any of the currently available drugs will cause either a practolol syndrome or malignant disease in man, but the need for careful appraisal by drug regulatory bodies and continued vigilance by all prescribers of beta-adrenoceptor blocking drugs remains.

TL;DR: The slow-channel blockers constitute a structurally diverse group of drugs with varying mechanisms of action, propensities for site of greatest cardiovascular activity, and clinical efficacy and the development of such compounds may offer further therapeutic possibilities in the control of a variety of cardiocirculatory diseases.

TL;DR: There is an extensive background on the androgen responsiveness of the mouse kidney which can be demonstrated histologically by hypertrophy of the Bowman's capsule and the proximal convoluted tubule and it is not certain at this time whether a similar mechanism is involved in the potentiation of androgen action on other organs such as the prostate.

TL;DR: The objective of this work has been to determine whether neuroactive drugs could be used to disrupt the parasites' physiology sufficiently to have therapeutic impact, while avoiding toxic effects on the host nervous system.