Showing papers in "Pharmacology & Therapeutics in 1984"
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873 citations
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TL;DR: The selective antiviral action of BVDU is based upon a specific phosphorylation by the virus-encoded deoxythymidine kinase (TK), inhibition of the viral DNA polymerase and/or incorporation into viral DNA.
97 citations
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79 citations
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TL;DR: This work has shown clear trends in remission of major depressive disorder in patients with a history of substance abuse, and these trends are likely to be sustained over the long term.
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TL;DR: In the present review, fluctuations of reductase activity with the cell cycle and the relativn of dNTP pools to this activity will be discussed, and a new model (intercalating model) of reduCTase regulation is proposed.
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TL;DR: Antiandrogens have been demonstrated to be beneficial in treating 5 clinical syndromes or diseases: acne, seborrhea, hirsutism with or without menstrual abnormalities; precocious puberty; benign prostatic hypertrophy; cancer of the prostate; and sexual deviates.
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TL;DR: In angina of effort, calcium antagonists are now becoming the agents of first choice in some centers, and in many patients, these diverse properties allow safe combination of calcium antagonists and beta-adrenoceptor blockers if due care is observed, especially in the case of nifedipine.
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TL;DR: It can be clarified why a compound might be excreted via liver or kidney and whether or not a compensation for the loss of one main excretion organ is possible or not and the developmental pattern of both elimination routes has consequences for drug use in paediatrics as well as geriatrics.