Journal•ISSN: 1026-7719
Phosphorus Sulfur and Silicon and The Related Elements
Taylor & Francis
About: Phosphorus Sulfur and Silicon and The Related Elements is an academic journal published by Taylor & Francis. The journal publishes majorly in the area(s): Catalysis & Alkyl. It has an ISSN identifier of 1026-7719. Over the lifetime, 11785 publications have been published receiving 78326 citations. The journal is also known as: Phosphorus, sulfur, and silicon & Phosphorus sulfur silicon relat. elem..
Topics: Catalysis, Alkyl, Aryl, Phosphorus, Reagent
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TL;DR: Aminophosphonates are analogues of amino acids in which a carboxylic moiety is replaced by phosphonic acid or related groups that inhibit enzymes involved in amino acid metabolism and thus affect the physiological activity of the cell.
Abstract: Aminophosphonates are analogues of amino acids in which a carboxylic moiety is replaced by phosphonic acid or related groups. Acting as antagonists of amino acids, they inhibit enzymes involved in amino acid metabolism and thus affect the physiological activity of the cell. These effects may be exerted as antibacterial, plant growth regulatory or neuromodulatory. Chosen representative examples of biologically active aminophosphonates are presented in some detail.
899 citations
TL;DR: In this paper, the reaction of carbon disulfide with sodium or potassium in dimethyl formamide yields 1,3dithiole-2-thione-4,5-dithiolate (1) and trithiocarbonate in equimolar amounts.
Abstract: Die Reaktion von Schwefelkohlenstoff mit Natrium oder Kalium fuhrt zur Bildung aquimolarer Mengen von 1.3-Dithiol-2-thion-4.5-dithiolat (1) und Trithiocarbonat. Durch Zugabe von ZnCl2 und NEt4Br last sich (1) stabilisieren. Der entstehende Zink-Komplex ermoglicht die Herstellung von 4.5-Bis(benzoylthio)-1.3-dithiol-2-thion (10), woraus durch Umsetzung mit Basen (1) in quantitativer Ausbeute wieder entsteht. Die Alkylierung von (1) fuhrt zu 4.5-Bis(alkylthio)-1.3-dithiol-2-thionen. (1) is ein neuer, schwefelreicher 1.2-Dithiolat-Ligand. Die Kristallstruktur des Bis-Chelates von (1) mit Ni(II) als (n-Bu4N)2-Salz bestatigt die fur (1) angenommene Struktur. The reaction of carbon disulfide with sodium or potassium in dimethyl formamide yields 1,3-dithiole-2-thione-4,5-dithiolate (1) and trithiocarbonate in equimolar amounts. (1) was stabilized by addition of ZnCl2 and NEt4Br. The resulting zinc complex enables the isolation of 4,5-bis(benzoylthio)-1,3-dithiole-2-thione (10). (1) can be recovered from...
408 citations
TL;DR: The analgesic activity of enkephalin analogs containing aminophosphonic acid residues at C-terminal posit... is shown to be linked to the high antibacterial activity of alafosfalin 2.
Abstract: 1-Aminoalkylphosphonic acids 1 as analogs of 1-amino-carboxylic acids are important because of their potential biological activity. These act as substrates or inhibitors of enzymes involved in the metabolism of amino acids. Several phosphono dipeptides and oligopeptides are known to repress bacterial growth. Many of these studies have been carried out using racemic l-amino- alkylphosphonic acids 1 although in several cases their activity has been shown to depend upon their absolute c~nfiguration. One such example is the high antibacterial activity of alafosfalin 2, N-(L-alany1)-L-1-aminoethylphosphonic acid, as compared to that of the other diastereoisomers. Alafosfalin 2 has been shown to act by facilitated transport into the bacterial cell wall where it is cleaved enzymatically to L-1-aminoethylphosphonic acid la which inhibits alanine racemase and related processes by simulating L-alanine. The analgesic activity of enkephalin analogs containing aminophosphonic acid residues at C-terminal posit...
150 citations
TL;DR: In this paper, an improved method of synthesizing thiosemicarbones is proposed, which should be efficient, high yield, general, and safe (avoids toxic or unpleasant reagents).
Abstract: Thiosemicarbazones of α-(N)-heterocyclic ketones and aldehydes possess a broad spectrum of potentially useful chemotherapeutic activities. Thus, the antimalarial, antibacterial, and antiviral properties of this class have been explored by Klayman, et al.1 The antileishmanial activity of a series of acetyl β-carboline thiosemicarbazones was recently described by Dodd and coworkers .2 The α-(N)-heterocyclic thiosemicarbazones act as tridentate ligands for transition metals3; this property has been implicated in their biological mechanism of action.4 The synthesis thiosemicarbazone-transition metal complexes and the spectroscopic investigation of structure and bonding in these complexes is being actively pursued 5 In order to facilitate these investigations, an improved method of synthesizing thiosemicarbones is desirable. Such a synthesis should be efficient (high yield), general (afford thiosemicarbazones of N4-monosubstitution or N4,N4-disubstitution patterns), safe (avoids toxic or unpleasant re...
144 citations
TL;DR: The solubility of elemental rhombic sulfur in water is 1.9(± 0.6) × 10−8 mole S8·kg−1 as discussed by the authors.
Abstract: The solubility of elemental rhombic sulfur in water is 1.9(±0.6) × 10−8 mole S8·kg−1. This value is in agreement with thermodynamic considerations on the solubility of sulfur and experimental data on sulfur hydrosols.
126 citations