Showing papers in "Phytomedicine in 2012"

TL;DR: The results indicate that the oils had a high inhibitory activity against tested bacteria, except for Pseudomonas aeruginosa, which is very promising since the use of these combinations for nosocomial infections treatment is likely to reduce the minimum effective dose of the antibiotics, thus minimizing their possible toxic side effects and treatment cost.

TL;DR: It was showed that RE inhibited the proliferation of ovarian cancer cell lines by affecting the cell cycle at multiple phases and induced apoptosis by modifying the expression of multiple genes regulating apoptosis.

TL;DR: Taken together, multiple exposures to lavender essential oils could effectively reverse spatial memory deficits induced by dysfunction of the cholinergic system in the rat brain and might provide an opportunity for management neurological abnormalities in dementia conditions.

TL;DR: Polyphenols have interactive and complementary effects, which suggest a possible application in the management of complex diseases and efforts to isolate individual components might be irrelevant for clinical medicine and/or human nutrition.

TL;DR: The results show that 7 compounds likely to be active compounds concerning to their pronounced inhibitory action on the activated inflammatory cells might be helpful to attenuate the irritant action of Euphorbiaceae plants and protect the gastrointestinal tissue from potent inflammatory injury, which should be beneficial to some diseases, like inflammatory bowel disease.

TL;DR: In vitro interaction between coriander essential oil and six different antibacterial drugs could improve the antimicrobial effectiveness of ciprofloxacin, gentamicin and tetracycline and may contribute to resensitize A. baumannii to the action of chloramphenicol.

TL;DR: The essential oil and its major components exhibited broad spectrum inhibition against all the bacterial strains with Gram-positive being more susceptible to the oil than Gram-negative bacteria.

TL;DR: Tested lichen compounds demonstrated a strong antioxidant, antimicrobial, and anticancer effects that suggest that these lichens can be used as new sources of the natural antimicrobial agents, antioxidants and antic cancer compounds.

TL;DR: The best evidence suggests that oral lavender supplements may have some therapeutic effects, however, further independent replications are needed before firm conclusions can be drawn.

TL;DR: Berberine significantly decreased fasting blood glucose, insulin levels, total cholesterol, triglyceride levels, urinary protein excretion, serum creatinine (Scr) and blood urea nitrogen (BUN) in diabetic rats.

TL;DR: The results showed that PA possesses the characteristics of selectively inducing cell death of tumor cells as no inhibition was observed in non-tumorigenic cells even at 30 μg/ml.

TL;DR: The improved hypoglycemic activity of the aspalathin-rutin mixture and the extract illustrated synergistic interactions of polyphenols in complex mixtures.

TL;DR: It is demonstrated that berberine is a potent lipid-lowering compound with a moderate weight loss effect, and may have a possible potential role in osteoporosis treatment/prevention.

TL;DR: Results showed that fucoidan isolated from U. pinnatifida may have a new therapeutic potential in the prevention angiogenesis-related diseases.

TL;DR: The present results suggested that systemic administration of an ASE extract could reduce the inflammatory and oxidant actions of CS, and should stimulate future studies on ASE as a potential agent to protect against CS-induced inflammation in humans.

TL;DR: The accumulated data on endophytic fungi isolated from plants that produce metabolites with antibacterial activity against human pathogenic bacteria are reviewed.

TL;DR: Light is shed on drug resistant reversing effect of curcumin in lung cancer cells by inhibiting HIF-1α expression and activating caspase-3, respectively.

TL;DR: In conclusion, asiaticoside promotes skin cell behaviors involved in wound healing; and as a bioactive component of an artificial skin, may have therapeutic value.

TL;DR: In this article, the authors investigated whether P. acnes biofilms could be eradicated by plant extracts or their active compounds, and whether other mechanisms besides killing of biofilm cells could be involved.

TL;DR: Curcumin provided protection against chronic ALD and the mechanism might be related to the alleviation of oxidative damage.

TL;DR: An endophytic fungus isolated from the medicinal plant Curcuma wenyujin L18 exhibited a broader antifungal spectrum and showed the strongest cytotoxic activity against H22 and MFC cancer cell lines, and Chaetoglobosin X (1) is hitherto unknown.

TL;DR: This study implies that carotenoids may be utilised as chemosensitisers, especially as adjuvants in chemotherapy.

TL;DR: Results suggested that P. chinensis saponins exert potential anticancer activity in treating tumors in nude mice and no toxic side effects.

TL;DR: Fucoxanthin (Fx) isolated from Undaria pinnatifida suppresses the development of hyperglycemia and hyperinsulinemia of diabetic/obese KK-A(y) mice after 2 weeks of feeding 0.2% Fx-containing diet and induces peroxisome proliferator activated receptor γ coactivator-1α, which has been reported to increase GLUT4 expression, in both soleus and EDL muscles.

TL;DR: Results indicate that curcumin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKCα, MAPK and NF-κB/AP-1 pathway in MCF-7 cells.

TL;DR: Combination of non-toxic concentrations of individual secondary metabolite with doxorubicin synergistically sensitized Caco-2 and CEM/ADR5000 cells, and significantly enhanced the cytotoxicity of doxorbicin.

TL;DR: It is demonstrated that in some combinations, the tested compounds acted in synergy to lower the susceptibility of S. aureus, S. epidermidis and L. monocytogenes to ampicillin and oxacillin, but no synergy was observed for P. aeruginosa.

TL;DR: The results suggested that the effect of BCPs against ALI might be related with its inhibitory effect on excessive activation of complement and on the production of proinflammatory mediators.

TL;DR: Danshensu is a useful marker for the quality control of Danshen water-extracts in antioxidant and vasodilation, while tanshinone IIA for anti-apoptotic potential of different extracts.

TL;DR: The in vitro antimicrobial activities of usnic acid were evaluated in combination with five therapeutically available antibiotics, using checkerboard microdilution assay against methicillin-resistant clinical isolates strains of Staphylococcus aureus to suggest this substance might be a good candidate for the individuation of novel templates for the development of new antimicrobial agents or combinations of drugs for chemotherapy.