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Showing papers in "Planta Medica in 1978"





Journal ArticleDOI
TL;DR: A stereospecificity in respect to both precursor and product in this plant cell biotransformation system is indicated in this in vitro cultured Mentha cell lines.
Abstract: Following previous results, which indicated that cell lines derived from different Mentha chemotypes were either capable or not capable to biotransform pulegone into isomenthone, we studied menthone biotransformation by in vitro cultured Mentha cell lines. All the six cell lines did transform (-)-menthone into another monoterpene. The latter was identified by GLC, TLC and NMR techniques as (+)-neomenthol. None of these cell lines reduced (+)-isomenthoneto the corresponding alcohol. These results indicate a stereospecificity in respect to both precursor and product in this plant cell biotransformation system.

45 citations







Journal ArticleDOI
TL;DR: The results suggest that the biologically potent saponins have an effect on the negatively charged carbohydrate portions of cell membrane.
Abstract: The effects of plant saponins, saikosaponins a, b 1 , b 2 , c and d extracted from BUPLEURI RADIX, on the surface contours and the distribution of surface anionic sites of E HRLICH ascites tumour cells were examined by electron microscope. Saikosaponins d and a having the bridged 13β, 28-epoxyoleanene system in the aglycone D-ring, which show stronger haemolytic activity and higher pharmacological potency than other saikosaponins, were found to cause a significant decrease in the negative charge on the cell surface and the destruction of microvilli. These results suggest that the biologically potent saponins have an effect on the negatively charged carbohydrate portions of cell membrane.

33 citations








Journal ArticleDOI
TL;DR: In this paper, the use of Strychnos afzelii Gilg (Loganiaceae) stem as chewing stick has been reported by several authors, and extracts of the stem bark were found to exhibit antimicrobial activity, among others against Streptococcus species connected with caries.
Abstract: The use of Strychnos afzelii Gilg (Loganiaceae) stem as chewing stick have been reported by several authors [1]. Extracts of the stem bark were found to exhibit antimicrobial activity, among others against Streptococcus species connected with caries. In the extracts the alkaloids bisnor–dihydrotoxiferine (I), bisnor–C–alkaloid H (II), caracurine V (IV) and Wieland–Gum–lich aldehyde (V) were identified. The tertiary dimeric indole alkaloids I, II and IV were found to be responsible for the antimicrobial effect.








Journal ArticleDOI
TL;DR: A study of the non quaternary alkaloids of trunk–barks of Polyalthia suaveolens Engl.
Abstract: A study of the non quaternary alkaloids of trunk–barks of Polyalthia suaveolens Engl. and Diels, Annonaceae, resulted in the isolation of eleven alkaloids, four of which are new compounds. Eight alkaloids are 7–hydroxy or 7–methoxy aporphines; oliverine, oliveridine and polyalthine were found in major amounts. Two oxoaporphines, lysicamine and oxostephanine, are present. Polyveoline, isolated for the first time, is presently under investigation. The phytochemical significance of these alkaloids is discussed.




Journal ArticleDOI
TL;DR: The low concentration of lo-* moll1 inhibit protein synthesis in lymphocytes and the sesquiterpene betainyl-anguidine from mouse spleen rapidly after addiand the structurally related verrucarin to the cell culture.
Abstract: A a t the low concentration of lo-* moll1 inhibit protein synthesis in lymphocytes The sesquiterpene betainyl-anguidine from mouse spleen rapidly after addiand the structurally related verrucarin .tion to the cell culture. DNA svnthesis 1 Dedicated 10 Professor ADOLF BUTENANDT is at low 'Oncentrafin the occasion of his 75th birthday. tions whereas RNA synthesis is much T hi s do cu m en t w as d ow nl oa de d fo r pe rs on al u se o nl y. U na ut ho riz ed d is tr ib ut io n is s tr ic tly p ro hi bi te d.