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Showing papers in "Psychological Bulletin in 2006"


Journal ArticleDOI
TL;DR: Meta-analysis showed that a medium-to-large change in intention leads to a small- to-medium change in behavior, and several conceptual factors, methodological features, and intervention characteristics that moderate intention-behavior consistency were identified.
Abstract: Numerous theories in social and health psychology assume that intentions cause behaviors. However, most tests of the intention- behavior relation involve correlational studies that preclude causal inferences. In order to determine whether changes in behavioral intention engender behavior change, participants should be assigned randomly to a treatment that significantly increases the strength of respective intentions relative to a control condition, and differences in subsequent behavior should be compared. The present research obtained 47 experimental tests of intention-behavior relations that satisfied these criteria. Meta-analysis showed that a medium-to-large change in intention (d = 0.66) leads to a small-to-medium change in behavior (d = 0.36). The review also identified several conceptual factors, methodological features, and intervention characteristics that moderate intention-behavior consistency.

3,109 citations


Journal ArticleDOI
TL;DR: The present study used meta-analytic techniques to determine the patterns of mean-level change in personality traits across the life course and showed that people increase in measures of social dominance, conscientiousness, and emotional stability in young adulthood and decrease in both of these domains in old age.
Abstract: The present study used meta-analytic techniques (number of samples = 92) to determine the patterns of mean-level change in personality traits across the life course. Results showed that people increase in measures of social dominance (a facet of extraversion), conscientiousness, and emotional stability, especially in young adulthood (age 20 to 40). In contrast, people increase on measures of social vitality (a 2nd facet of extraversion) and openness in adolescence but then decrease in both of these domains in old age. Agreeableness changed only in old age. Of the 6 trait categories, 4 demonstrated significant change in middle and old age. Gender and attrition had minimal effects on change, whereas longer studies and studies based on younger cohorts showed greater change.

2,791 citations


Journal ArticleDOI
TL;DR: An integrative review of the available evidence on implicit and explicit attitude change that is guided by a distinction between associative and propositional processes is provided.
Abstract: A central theme in recent research on attitudes is the distinction between deliberate, "explicit" attitudes and automatic, "implicit" attitudes. The present article provides an integrative review of the available evidence on implicit and explicit attitude change that is guided by a distinction between associative and propositional processes. Whereas associative processes are characterized by mere activation independent of subjective truth or falsity, propositional reasoning is concerned with the validation of evaluations and beliefs. The proposed associative-propositional evaluation (APE) model makes specific assumptions about the mutual interplay of the 2 processes, implying several mechanisms that lead to symmetric or asymmetric changes in implicit and explicit attitudes. The model integrates a broad range of empirical evidence and implies several new predictions for implicit and explicit attitude change.

2,191 citations


Journal ArticleDOI
TL;DR: A speculative peer-socialization model is presented based on this review of sex differences in several peer relationship processes, including behavioral and social-cognitive styles, stress and coping, and relationship provisions, which suggests that sex-linked relationship processes have costs and benefits for girls' and boys' adjustment.
Abstract: Theory and research on sex differences in adjustment focus largely on parental, societal, and biological influences. However, it also is important to consider how peers contribute to girls' and boys' development. This article provides a critical review of sex differences in several peer relationship processes, including behavioral and social-cognitive styles, stress and coping, and relationship provisions. The authors present a speculative peer-socialization model based on this review in which the implications of these sex differences for girls' and boys' emotional and behavioral development are considered. Central to this model is the idea that sex-linked relationship processes have costs and benefits for girls' and boys' adjustment. Finally, the authors present recent research testing certain model components and propose approaches for testing understudied aspects of the model.

2,036 citations


Journal ArticleDOI
TL;DR: Meta-analyses of studies yielding sex-specific risk of potentially traumatic events (PTEs) and posttraumatic stress disorder (PTSD) indicated that female participants were more likely than male participants to meet criteria for PTSD, although they were less likely to experience PTEs.
Abstract: Meta-analyses of studies yielding sex-specific risk of potentially traumatic events (PTEs) and posttraumatic stress disorder (PTSD) indicated that female participants were more likely than male participants to meet criteria for PTSD, although they were less likely to experience PTEs. Female participants were more likely than male participants to experience sexual assault and child sexual abuse, but less likely to experience accidents, nonsexual assaults, witnessing death or injury, disaster or fire, and combat or war. Among victims of specific PTEs (excluding sexual assault or abuse), female participants exhibited greater PTSD. Thus, sex differences in risk of exposure to particular types of PTE can only partially account for the differential PTSD risk in male and female participants.

1,815 citations


Journal ArticleDOI
TL;DR: In this paper, the authors review the hypothesis that mind-wandering can be integrated into standard executive models of attention and show that it often occurs in the absence of explicit intention.
Abstract: This article reviews the hypothesis that mind wandering can be integrated into executive models of attention. Evidence suggests that mind wandering shares many similarities with traditional notions of executive control. When mind wandering occurs, the executive components of attention appear to shift away from the primary task, leading to failures in task performance and superficial representations of the external environment. One challenge for incorporating mind wandering into standard executive models is that it often occurs in the absence of explicit intention--a hallmark of controlled processing. However, mind wandering, like other goal-related processes, can be engaged without explicit awareness; thus, mind wandering can be seen as a goal-driven process, albeit one that is not directed toward the primary task.

1,737 citations


Journal ArticleDOI
TL;DR: Psychological and clinical effects of meditation are summarized, integrated, and discussed with respect to neuroimaging data, and meditation appears to reflect changes in anterior cingulate cortex and dorsolateral prefrontal areas.
Abstract: Neuroelectric and imaging studies of meditation are reviewed. Electroencephalographic measures indicate an overall slowing subsequent to meditation, with theta and alpha activation related to proficiency of practice. Sensory evoked potential assessment of concentrative meditation yields amplitude and latency changes for some components and practices. Cognitive event-related potential evaluation of meditation implies that practice changes attentional allocation. Neuroimaging studies indicate increased regional cerebral blood flow measures during meditation. Taken together, meditation appears to reflect changes in anterior cingulate cortex and dorsolateral prefrontal areas. Neurophysiological meditative state and trait effects are variable but are beginning to demonstrate consistent outcomes for research and clinical applications. Psychological and clinical effects of meditation are summarized, integrated, and discussed with respect to neuroimaging data.

1,384 citations


Journal ArticleDOI
TL;DR: A meta-analysis of the distributed practice effect suggests that ISI and retention interval operate jointly to affect final-test retention; specifically, the ISI producing maximal retention increased as retention interval increased.
Abstract: The authors performed a meta-analysis of the distributed practice effect to illuminate the effects of temporal variables that have been neglected in previous reviews. This review found 839 assessments of distributed practice in 317 experiments located in 184 articles. Effects of spacing (consecutive massed presentations vs. spaced learning episodes) and lag (less spaced vs. more spaced learning episodes) were examined, as were expanding interstudy interval (ISI) effects. Analyses suggest that ISI and retention interval operate jointly to affect final-test retention; specifically, the ISI producing maximal retention increased as retention interval increased. Areas needing future research and theoretical implications are discussed.

1,379 citations


Journal ArticleDOI
TL;DR: Results of random effects analyses indicate that experimental disclosure is effective, with a positive and significant average r-effect size of .075, and a number of moderators were identified.
Abstract: Disclosing information, thoughts, and feelings about personal and meaningful topics (experimental disclosure) is purported to have various health and psychological consequences (e.g., J. W. Pennebaker, 1993). Although the results of 2 small meta-analyses (P. G. Frisina, J. C. Borod, & S. J. Lepore, 2004; J. M. Smyth, 1998) suggest that experimental disclosure has a positive and significant effect, both used a fixed effects approach, limiting generalizability. Also, a plethora of studies on experimental disclosure have been completed that were not included in the previous analyses. One hundred forty-six randomized studies of experimental disclosure were collected and included in the present meta-analysis. Results of random effects analyses indicate that experimental disclosure is effective, with a positive and significant average r-effect size of .075. In addition, a number of moderators were identified.

1,279 citations


Journal ArticleDOI
TL;DR: The findings indicated that attitudes correlated with a future behavior more strongly when they were easy to recall and stable over time and when participants had direct experience with the attitude object and reported their attitudes frequently.
Abstract: A meta-analysis (k of conditions = 128; N = 4,598) examined the influence of factors present at the time an attitude is formed on the degree to which this attitude guides future behavior. The findings indicated that attitudes correlated with a future behavior more strongly when they were easy to recall (accessible) and stable over time. Because of increased accessibility, attitudes more strongly predicted future behavior when participants had direct experience with the attitude object and reported their attitudes frequently. Because of the resulting attitude stability, the attitude-behavior association was strongest when attitudes were confident, when participants formed their attitude on the basis of behavior-relevant information, and when they received or were induced to think about one- rather than two-sided information about the attitude object.

1,183 citations


Journal ArticleDOI
TL;DR: The authors examine whether features of automaticity can be disentangled on a conceptual level, because only then is the separate investigation of them worth the effort and conclude that the conceptual analysis of features is to a large extent feasible.
Abstract: Several theoretical views of automaticity are discussed. Most of these suggest that automaticity should be diagnosed by looking at the presence of features such as unintentional, uncontrolled/uncontrollable, goal independent, autonomous, purely stimulus driven, unconscious, efficient, and fast. Contemporary views further suggest that these features should be investigated separately. The authors examine whether features of automaticity can be disentangled on a conceptual level, because only then is the separate investigation of them worth the effort. They conclude that the conceptual analysis of features is to a large extent feasible. Not all researchers agree with this position, however. The authors show that assumptions of overlap among features are determined by the other researchers’ views of automaticity and by the models they endorse for information processing in general.

Journal ArticleDOI
TL;DR: The authors used meta-analytical techniques to estimate the magnitude of gender differences in mean level and variability of 35 dimensions and 3 factors of temperament in children ages 3 months to 13 years, finding moderate gender differences favoring girls, consistent with boys' greater incidence of externalizing disorders.
Abstract: The authors used meta-analytical techniques to estimate the magnitude of gender differences in mean level and variability of 35 dimensions and 3 factors of temperament in children ages 3 months to 13 years. Effortful control showed a large difference favoring girls and the dimensions within that factor (e.g., inhibitory control: d = -.41, perceptual sensitivity: d = -0.38) showed moderate gender differences favoring girls, consistent with boys' greater incidence of externalizing disorders. Surgency showed a difference favoring boys, as did some of the dimensions within that factor (e.g., activity: d = 0.33, high-intensity pleasure: d = 0.30), consistent with boys' greater involvement in active rough-and-tumble play. Negative affectivity showed negligible gender differences.

Journal ArticleDOI
TL;DR: Evidence supporting several potential mechanisms linking burnout with ill health, including the metabolic syndrome, dysregulation of the hypothalamic-pituitary-adrenal axis along with sympathetic nervous system activation, sleep disturbances, systemic inflammation, impaired immunity functions, blood coagulation and fibrinolysis, and poor health behaviors is presented.
Abstract: Burnout is characterized by emotional exhaustion, physical fatigue, and cognitive weariness, resulting from prolonged exposure to work-related stress. The authors review the accumulated evidence suggesting that burnout and the related concept of vital exhaustion are associated with increased risk of cardiovascular disease and cardiovascular-related events. The authors present evidence supporting several potential mechanisms linking burnout with ill health, including the metabolic syndrome, dysregulation of the hypothalamic-pituitary-adrenal axis along with sympathetic nervous system activation, sleep disturbances, systemic inflammation, impaired immunity functions, blood coagulation and fibrinolysis, and poor health behaviors. The association of burnout and vital exhaustion with these disease mediators suggests that their impact on health may be more extensive than currently indicated.

Journal ArticleDOI
TL;DR: Results show youth depression treatments appear to produce effects that are significant but modest in their strength, breadth, and durability, and Cognitive treatments (e.g., cognitive-behavioral therapy) fared no better than noncognitive approaches.
Abstract: Serious sequelae of youth depression, plus recent concerns over medication safety, prompt growing interest in the effects of youth psychotherapy. In previous meta-analyses, effect sizes (ESs) have averaged .99, well above conventional standards for a large effect and well above mean ES for other conditions. The authors applied rigorous analytic methods to the largest study sample to date and found a mean ES of .34, not superior but significantly inferior to mean ES for other conditions. Cognitive treatments (e.g., cognitive-behavioral therapy) fared no better than noncognitive approaches. Effects showed both generality (anxiety was reduced) and specificity (externalizing problems were not), plus short- but not long-term holding power. Youth depression treatments appear to produce effects that are significant but modest in their strength, breadth, and durability.

Journal ArticleDOI
TL;DR: This meta-analytic review summarizes obesity prevention programs and their effects and investigates participant, intervention, delivery, and design features associated with larger effects.
Abstract: This meta-analytic review summarizes obesity prevention programs and their effects and investigates participant, intervention, delivery, and design features associated with larger effects. A literature search identified 64 prevention programs seeking to produce weight gain prevention effects, of which 21% produced significant prevention effects that were typically pre- to post effects. Larger effects emerged for programs that targeted children and adolescents (vs. preadolescents) and females, programs that were relatively brief, programs that solely targeted weight control versus other health behaviors (e.g., smoking), programs evaluated in pilot trials, and programs wherein participants must have self-selected into the intervention. Other factors, including mandated improvements in diet and exercise, sedentary behavior reduction, delivery by trained interventionists, and parental involvement, were not associated with significantly larger effects.

Journal ArticleDOI
TL;DR: A model of risk regulation is proposed to explain how people balance the goal of seeking closeness to a romantic partner against the opposing goal of minimizing the likelihood and pain of rejection.
Abstract: A model of risk regulation is proposed to explain how people balance the goal of seeking closeness to a romantic partner against the opposing goal of minimizing the likelihood and pain of rejection. The central premise is that confidence in a partner's positive regard and caring allows people to risk seeking dependence and connectedness. The risk regulation system consists of 3 interconnected "if--then" contingency rules, 1 cognitive, 1 affective, and 1 behavioral. The authors describe how general perceptions of a partner's regard structure the sensitivity of these 3 "if--then" rules in risky relationship situations. The authors then describe the consequences of such situated "if--then" rules for relationship well-being and conclude by integrating other theoretical perspectives and outlining future research directions.

Journal ArticleDOI
TL;DR: The findings directly challenge the belief that there are large differences in dissatisfaction between White and all non-White women and suggest that body dissatisfaction may not be the golden girl problem promoted in the literature.
Abstract: The prevailing view in popular culture and the psychological literature is that White women have greater body dissatisfaction than women of color. In this meta-analysis, 6 main effect sizes were obtained for differences among Asian American, Black, Hispanic, and White women with a sample of 98 studies, yielding 222 effect sizes. The average d for the White-Black comparison was 0.29, indicating that White women are more dissatisfied, but the difference is small. All other comparisons were smaller, and many were close to zero. The findings directly challenge the belief that there are large differences in dissatisfaction between White and all non-White women and suggest that body dissatisfaction may not be the golden girl problem promoted in the literature. Implications for theory and treatment are discussed.

Journal ArticleDOI
TL;DR: The authors conducted a comprehensive review to understand the relation between personality and aggressive behavior, under provoking and nonprovoking conditions and revealed that some personality variables influenced aggressive behavior under both neutral and provocation conditions, whereas others influencedaggressive behavior only under provocation.
Abstract: The authors conducted a comprehensive review to understand the relation between personality and aggressive behavior, under provoking and nonprovoking conditions. The qualitative review revealed that some personality variables influenced aggressive behavior under both neutral and provocation conditions, whereas others influenced aggressive behavior only under provocation. Studies that assessed personality variables and that directly measured aggressive behavior were included in the quantitative review. Analyses revealed that trait aggressiveness and trait irritability influenced aggressive behavior under both provoking and neutral conditions but that other personality variables (e.g., trait anger, Type A personality, dissipation-rumination) influenced aggressive behavior only under provoking conditions. The authors discuss possible relations between these patterns of aggressive behavior and the personality dimensions of Agreeableness and Neuroticism and consider implications for theories of aggression.

Journal ArticleDOI
TL;DR: This review examines how the intracategory variability of actual events reported in their broad checklist categories has been addressed within the tradition of economical checklist approaches, and assess the prospects for relatively economical, as well as reliable and valid, solutions.
Abstract: An explosion of research on life events has occurred since the publication of the Holmes and Rahe checklist in 1967. Despite criticism, especially of their use in research on psychopathology, such economical inventories have remained dominant. Most of the problems of reliability and validity with traditional inventories can be traced to the intracategory variability of actual events reported in their broad checklist categories. The purposes of this review are, first, to examine how this problem has been addressed within the tradition of economical checklist approaches; second, to determine how it has been dealt with by far less widely used and far less economical labor-intensive interview and narrative-rating approaches; and, third, to assess the prospects for relatively economical, as well as reliable and valid, solutions.

Journal ArticleDOI
TL;DR: The empirical evidence for the addiction-Stroop effect is critically reviewed, meta-analyses of alcohol-related and smoking-related studies are presented, and the motivational theory of current concerns appears to provide the most complete account of the phenomenon.
Abstract: Decisions about using addictive substances are influenced by distractions by addiction-related stimuli, of which the user might be unaware. The addiction-Stroop task is a paradigm used to assess this distraction. The empirical evidence for the addiction-Stroop effect is critically reviewed, and meta-analyses of alcohol-related and smoking-related studies are presented. Studies finding the strongest effects were those in which participants had strong current concerns about an addictive substance or such concerns were highlighted through experimental manipulations, especially those depriving participants of the substance. Theories to account for addiction-related attentional bias are discussed, of which the motivational theory of current concerns appears to provide the most complete account of the phenomenon. Recommendations are made for maximizing the precision of the addiction-Stroop test in future research.

Journal ArticleDOI
TL;DR: The authors show that perceptual or conceptual similarity is not necessary to obtain mapping effects; a type of structural similarity is sufficient and polarity correspondence is sufficient to produce mapping effects.
Abstract: Differences in performance with various stimulus-response mappings are among the most prevalent findings for binary choice reaction tasks. The authors show that perceptual or conceptual similarity is not necessary to obtain mapping effects; a type of structural similarity is sufficient. Specifically, stimulus and response alternatives are coded as positive and negative polarity along several dimensions, and polarity correspondence is sufficient to produce mapping effects. The authors make the case for this polarity correspondence principle using the literature on word-picture verification and then provide evidence that polarity correspondence is a determinant of mapping effects in orthogonal stimulus-response compatibility, numerical judgment, and implicit association tasks. The authors conclude by discussing implications of this principle for interpretation of results from binary choice tasks and future model development.

Journal ArticleDOI
TL;DR: The authors hypothesize that ADHD is due to noncortical dysfunction that manifests early in ontogeny, remains static throughout the lifetime, and is not associated with the remission of symptomatology.
Abstract: Most neural models for the pathophysiology of attention-deficit/hyperactivity disorder (ADHD) have centered on the prefrontal cortex and its interconnections with the striatum and other subcortical structures. However, research only partially supports these models, and they do not correspond with the development of the prefrontal cortex and its interrelated neurocircuitry. The neural and functional development of the prefrontal cortex more closely parallels recovery from ADHD as indicated by the developmental remission of symptomatology. The authors hypothesize that ADHD is due to noncortical dysfunction that manifests early in ontogeny, remains static throughout the lifetime, and is not associated with the remission of symptomatology. Data supporting this neurodevelopmental model of prefrontal cortex function in ADHD are reviewed. Research and treatment implications are discussed.

Journal ArticleDOI
TL;DR: A moderator analysis showed that the actor-observer asymmetry held only when the actor was portrayed as highly idiosyncratic, when hypothetical events were explained, when actor and observer were intimates, or when free-response explanations were coded.
Abstract: The actor-observer hypothesis (E. E. Jones & R. E. Nisbett, 1971) states that people tend to explain their own behavior with situation causes and other people's behavior with person causes. Widely known in psychology, this asymmetry has been described as robust, firmly established, and pervasive. However, a meta-analysis on 173 published studies revealed average effect sizes from d = -0.016 to d = 0.095. A moderator analysis showed that the asymmetry held only when the actor was portrayed as highly idiosyncratic, when hypothetical events were explained, when actor and observer were intimates, or when free-response explanations were coded. In addition, the asymmetry held for negative events, but a reverse asymmetry held for positive events. This valence effect may indicate a self-serving pattern in attribution, but across valence, no actor-observer asymmetry exists.

Journal ArticleDOI
TL;DR: The authors conclude that fit-focused secondary control is adaptive for coping, is relatively preferred in interdependent cultural contexts, and may serve the motivation for relatedness.
Abstract: Conclusions about secondary control have been hindered by researchers' disparate interpretations of the construct. The current review offers a definition that reflects commonality among researchers and the spirit of the original article (F. Rothbaum, J. R. Weisz, & S. S. Snyder, 1982): Secondary control refers to the process by which people adjust some aspect of the self and accept circumstances as they are. The authors also identify a "fit versus control" dimension, along which secondary control research can be classified and reviewed. The authors conclude that fit-focused secondary control is adaptive for coping, is relatively preferred in interdependent cultural contexts, and may serve the motivation for relatedness. Control-focused definitions lead to different interpretations of the function and cultural nature of secondary control. The proposed definition and dimension should enable researchers to articulate assumptions about the function and correlates of secondary control.

Journal ArticleDOI
TL;DR: The authors offer a new, integrative conceptualization of the relational self based on a synthesis of recent approaches to the self and significant others that provides a sharper and fuller definition than does any existing approach alone and a common framework to interpret findings from separate literatures.
Abstract: The authors offer a new, integrative conceptualization of the relational self based on a synthesis of recent approaches to the self and significant others. This conceptualization provides a sharper and fuller definition of the relational self than does any existing approach alone and a common framework to interpret findings from separate literatures. The authors then present 5 propositions and evidence to support the thesis that relational selves exert a pervasive influence on interpersonal life. Specifically, relational selves (a) shape a wide range of psychological processes and outcomes, (b) exert their influence automatically, (c) serve basic orientation and meaning functions, (d) provide continuity and context-specific variability in personality, and (e) carry implications for psychological well-being. Discussion focuses on remaining issues and implications for future research.

Journal ArticleDOI
TL;DR: The results of their meta-analysis are consistent with the conclusions about modest change after age 30 and the origins of age changes might be found either in environmental influences common to all cultures or in biologically based intrinsic maturation.
Abstract: Comments on the original article "Patterns of Mean-Level Change in Personality Traits Across the Life Course: A Meta-Analysis of Longitudinal Studies," by B. W. Roberts, K. W. Walton, and W. Viechtbauer. Although Roberts et al depicted the present authors as proponents of the immutability of traits, in fact we have always acknowledged the possibility of change, and we are pleased that the results of their meta-analysis are consistent with our conclusions about modest change after age 30. We agree with B.W. Roberts et al that analyses should be conducted at the level of more specific traits, but prefer the 30 facets of the Revised NEO Personality Inventory to the Social Dominance-Social Vitality distinction. The origins of age changes might be found either in environmental influences common to all cultures or in biologically based intrinsic maturation; we offer some reasons for preferring the latter interpretation. Meta-analyses are useful but not definitive, and the resolution of the origin question lies in further research.

Journal ArticleDOI
Don C. Donderi1
TL;DR: Form complexity and form probability are shown to be linked through their reciprocal relationship in complexity theory, which is in turn shows to be consistent with recent developments in perceptual learning and neural circuit theory.
Abstract: The idea of visual complexity, the history of its measurement, and its implications for behavior are reviewed, starting with structuralism and Gestalt psychology at the beginning of the 20th century and ending with visual complexity theory, perceptual learning theory, and neural circuit theory at the beginning of the 21st. Evidence is drawn from research on single forms, form and texture arrays and visual displays. Form complexity and form probability are shown to be linked through their reciprocal relationship in complexity theory, which is in turn shown to be consistent with recent developments in perceptual learning and neural circuit theory. Directions for further research are suggested.

Journal ArticleDOI
TL;DR: The authors investigate the effect of chronic exercise on feelings of energy and fatigue using meta-analytic techniques and highlight the need for research identifying the most useful control conditions for accurately interpreting mental health outcome data obtained in chronic exercise investigations.
Abstract: The authors investigated the effect of chronic exercise on feelings of energy and fatigue using meta-analytic techniques. Chronic exercise increased feelings of energy and lessened feelings of fatigue compared with control conditions by a mean effect delta of 0.37. The effect varied according to the presence or absence of a placebo control or whether chronic exercise was completed alone or in combination with an additional therapy. Investigations that used a placebo control and examined chronic exercise alone found no effect of chronic exercise on feelings of energy and fatigue. Certain placebo controls may increase feelings of energy and lessen feelings of fatigue when used with older adults or people with psychological distress. The results highlight the need for research identifying the most useful control conditions for accurately interpreting mental health outcome data obtained in chronic exercise investigations.

Journal ArticleDOI
TL;DR: Meta-analyses were conducted to determine the magnitude of relationships between polymorphisms in 2 genes, ALDH2 and ADH1B, with alcohol dependence in Asians, and possession of 1 variant *2 allele was protective against alcohol dependence.
Abstract: Meta-analyses were conducted to determine the magnitude of relationships between polymorphisms in 2 genes, ALDH2 and ADH1B, with alcohol dependence in Asians. For each gene, possession of 1 variant *2 allele was protective against alcohol dependence, and possession of a 2nd *2 allele did not offer significant additional protection. The protective effects of these 2 gene polymorphisms were independent. Diagnostic criteria, recruitment strategy, and Japanese ethnicity moderated the effect of ALDH2*2. Recruitment strategy and gender moderated the effect of ADH1B*2. These findings highlight the importance of methodological issues and potential gene-gene and gene-environment interactions that must be considered when examining relationships between genetic polymorphisms and phenotypes.

Journal ArticleDOI
William D. Hopkins1
TL;DR: Overall, the proportion of right handedness is lower in great apes compared with humans, and various methodological and theoretical explanations for this discrepancy are discussed.
Abstract: Historically, population-level handedness has been considered a hallmark of human evolution. Whether nonhuman primates exhibit population-level handedness remains a topic of considerable debate. This paper summarizes published data on handedness in great apes. Comparative analysis indicated that chimpanzees and bonobos show population-level right handedness, whereas gorillas and orangutans do not. All ape species showed evidence of population-level handedness when considering specific tasks. Familial analyses in chimpanzees indicated that offspring and maternal (but not paternal) handedness was significantly positively correlated, but this finding was contingent upon the classification criteria used to evaluate hand preference. Overall, the proportion of right handedness is lower in great apes compared with humans, and various methodological and theoretical explanations for this discrepancy are discussed.