Showing papers in "Radiotherapy and Oncology in 2009"

TL;DR: In this paper, the authors conducted an individual patient data (IPD) meta-analysis, which showed that chemotherapy improved survival in patients curatively treated for non-metastatic head and neck squamous cell carcinoma (HNSCC), with a higher benefit with concomitant chemotherapy.

TL;DR: Combination with radiotherapy renders remaining cells more sensitive to irradiation, emphasizing how interference with tumor cell metabolism may complement current anticancer modalities.

TL;DR: The best available approach employs integrated PET/CT images, acquired on a dual scanner in the radiotherapy treatment position after administration of tracer according to a standardized protocol, with careful optimization of images within the RT planning system and carefully considered rules for contouring tumor volumes.

TL;DR: All approaches yield treatment plans of improved quality when compared to 3D-conformal treatments, with serial tomotherapy providing best OAR sparing and VMAT being the most efficient treatment option in the authors' comparison.

TL;DR: Target coverage and homogeneity results improved with RA2 plans compared to both RA1 and IMRT, while only RA2 offered improved target coverage with respect to conventional IMRT.

TL;DR: Efforts should be made to base SPM reduction on solid data and not on speculation or models built on debatable hypotheses regarding the dose-carcinogenic effect relationship, as preliminary data suggest that SPMs are mainly observed in tissues having absorbed doses above 2 Gy and that their incidence increases with the dose.

TL;DR: The rectum is the most investigated organ: the largest studies on dose-volume modelling of rectal toxicity show quite consistent results, suggesting that sufficiently reliable dose- volume/EUD-based constraints can be safely applied in most clinical situations.

TL;DR: This Consensus Conference represents an expertise opinion process that may help shape future programs, investigational protocols, and guidelines for staging and treatment of rectal cancer throughout Europe.

TL;DR: A significant dependence of local control on D100 and D90 for HR CTV was found and tumour control rates of >90% can be expected at doses >67 Gy and 86 Gy, respectively.

TL;DR: Comparisons with volumetric-modulated arc therapy for complex-shaped target volumes with a simultaneous integrated boost for radiotherapy for prostate cancer and cancer of the paranasal sinuses reveal the complexity of the target volume determined whether single arc VMAT was equivalent to ss-IMRT.

TL;DR: The Head and Neck Working Group of the European Brachytherapy Group (GEC-ESTRO) decided to formulate the present consensus recommendations, mainly based on clinical experience accumulated by the members of the working group over several decades and the respective publications.

TL;DR: Excellent local control of 96% at 1- and 2-years was achieved using 60 Gy in three fractions for NSCLC patients treated with the real-time tumor tracking, and toxicity was low.

TL;DR: In this article, the authors provide a systematic overview of all phase I and II studies and propose inclusion criteria for patients in accelerated partial breast irradiation (APBI) protocols, based on evidence from previous studies on patient/tumour characteristics and pattern of local recurrences.

TL;DR: Observations uncover a repair pathway with unexpected biochemical constitution and interesting cell cycle and growth factor regulation and generate a framework for investigating the mechanistic basis of HRR contribution to DSB repair.

TL;DR: RapidArc showed improvements in organs at risk and healthy tissue sparing with uncompromised target coverage when double arcs are applied, and Optimal results were also achieved anyway with IMRT plans.

TL;DR: The authors' in vivo imaging results confirm previous in vitro data demonstrating that CAI binding and retention require exposure to hypoxia, indicating the potential of patient selection for CA IX-directed therapies.

TL;DR: The location of residual metabolic-active areas within the primary tumour after therapy corresponded with the original high FDG uptake areas pre-radiotherapy, ultimately enabling selective-boosting of tumour sub-volumes.

TL;DR: The TDRS is a simple and validated measure to predict swallowing dysfunction after curative (CH) RT for HNC and enables identification of patients who may benefit from strategies aiming at prevention of swallowing dysfunction before treatment and/or emerging IMRT techniques aiming at sparing anatomical structures that are involved in swallowing.

TL;DR: Both RT schedules adopted were effective and MSCC patients may achieve palliation with minimal toxicity and inconvenience with a single-dose of 8 Gy.

TL;DR: Dosimetric properties of unflattened megavoltage photon beams are determined and phantom scatter reference data need to be reconsidered for medical accelerators operated without a flattening filter.

TL;DR: A model of the allelic architecture that may underlie differences in normal tissue radiosensitivity is proposed that is based on theoretical considerations and experiences from other scientific fields and discusses how future studies should be designed in order to successfully unravel the genetics ofnormal tissue radios sensitivity.

TL;DR: Human salivary glands contain a similar 'putative' stem cell population as rodents, expressing c-kit and capable of in vitro differentiation and self-renewal, which may have the potential to reduce radiotherapy-induced salivARY gland dysfunction in patients.

TL;DR: The novel volumetric intensity-modulated arc therapy (RA) for planning and delivery enabled much faster treatment for three patients with different fractionation schemes, which reduces the risk of intrafraction motion and is more patient friendly.

TL;DR: In this group of patients, the risk for radiation-induced rib fracture following hypofractionated SBRT was related to the dose to 2 cm(3) of the rib.

TL;DR: In this paper, the frequency of brachial plexopathy in early-stage non-small cell lung cancer treated with stereotactic body radiotherapy was reported in 253 patients.

TL;DR: Both PB algorithms overestimated the target dose, the overestimation increasing as rho(lung) decreased, and the AAA(Ecl) and CCC(OMP) algorithms appear to be adequate alternatives to MC.

TL;DR: BM urethral strictures are the most common late grade 2 or more urinary toxicity following HDR brachytherapy for prostate cancer and most are manageable with minimally invasive procedures.

TL;DR: In this paper, a questionnaire was sent to all members of the EORTC Radiation Oncology Group and Head and Neck Group (111 institutions) to evaluate the widespread use of cetuximab and radiotherapy in HNC and to estimate the frequency of grades III and IV skin reactions in the radiation portals associated with this protocol.

TL;DR: The risk of TRP varied significantly, depending on radiation dose-volume parameters and patient smoking status, and further studies are needed to identify biological basis of smoking effect and methods to reduce the incidence ofTRP.

TL;DR: There was no statistically significant difference in local control or survival between the high boost dose of 26 Gy and the low boost doses of 10 Gy in patients with microscopically incomplete excision of early breast cancer.