Showing papers in "Regulatory Peptides in 2007"

TL;DR: It is concluded that GLP-1 modulates sodium homeostasis in the kidney most likely through a direct action via its GLp-1R in proximal tubular cells.

TL;DR: A number of studies provided convergent evidence that ghrelin injected intracerebroventricularly or peripherally did not influence food intake, body weight gain, gastric transit, gastrointestinal motility, and gastric vagal afferent activity, as well as pituitary hormone secretions, in rats or mice.

TL;DR: Since OT administration improved renal function and microscopic damage, along with the alleviation of oxidant tissue responses, it appears that oxytocin protects renal tissue against I/R-induced oxidative damage.

TL;DR: The present data suggest that low rather than high-intensity exercise stimulates ghrelin levels independent of exercise duration, and Stimulation of food intake during prolonged exercise is most likely not due to changes of gh Relin.

TL;DR: Results provide partial support for the contention that ghrelin pretreatment can augment the rewarding effects of sub-threshold doses of COC in a CPP procedure and are consistent with the view that gh Relin may play a role in the capacity of FR to augment psychostimulant action.

TL;DR: It is suggested that obestatin has no effect on pituitary hormone secretions despite the presence of GPR39, a receptor for obstatin, in the pituitaries.

TL;DR: Apelin may produce relaxation in normal human splanchnic arteries, and this relaxation may be mediated in part by nitric oxide without involvement of prostanoids, as well as the role of Nitric oxide may be decreased in splan Schnic arteries from cirrhotic patients.

TL;DR: GLP-1 reduces the rise in ghrelin levels in the late postprandial period at supraphysiological plasma levels and most likely is indirectly mediated through its insulinotropic action.

TL;DR: It is suggested that PACAP38 has no major direct effect on rCBF in healthy volunteers, and the marked increase in heart rate and the reduction in r CBF caused by decreased P(et)CO(2) are important dose-limiting factors to consider in future clinical studies.

TL;DR: Findings suggest that these peptides could reduce the vascular resistance and could be used as functional food ingredients in the prevention and treatment of hypertension.

TL;DR: In an attempt to identify neurotransmitters and regulatory peptides that may contribute to the physiological, nutrient-related regulation of ghrelin secretion, the gh Relin cells in situ were challenged with a wide variety of candidate messengers, including known neurotransmits and candidates without measurable effects.

TL;DR: It is the tenet of this review that the authors have yet to fully understand the binding characteristics of brain angiotensin receptors and the extent of their distribution in the brain because of the inability to fully protect theAngiotensins from metabolic alteration until equilibrium binding conditions can be attained.

TL;DR: Evidence presented in this paper suggests that the effects of Ghr on both feeding and memory retention in extra-hypothalamic structures such as the hippocampus, could depend on the availability of 5-HT.

TL;DR: Observations that colonic apelin production is increased during and after DSS exposure indicate that apelin plays multiple roles during the different stages of colitis, and the stimulatory action of exogenous apelin on colonic epithelial proliferation suggests that the increased apelinProduction during intestinal recovery stage may contribute to the repair of the intestinal epithelium in experimental rodent models ofcolitis and in IBD patients.

TL;DR: Treatment with antileukinate protected mice against acute pancreatitis and associated lung injury, showing thereby that anti-chemokine therapy may be of value in this condition.

TL;DR: It is concluded that the new CgB assay can serve as a complement to CgA measurements as an important tumour marker for neuroendocrine tumours.

TL;DR: Results show that stimulation of NF-kappaB and AP-1 pathway mediate hepatic fibrogenesis induced by intrahepatic RAAS and exert anti-fibrosis effect through inhibiting NF- kappaB activation in liver.

TL;DR: AC3174 is an analog of exenatide that binds to the GLP-1 receptor in vitro and shares many of the biological and glucoregulatory activities of exanatide and GLp-1 in vivo.

TL;DR: HEK 293 cells stably expressing human melanocortin-3 receptor (MC3R) were exposed to NDP-MSH and this pathway is involved in cellular proliferation in HEK cells expressing MC3R and this pathways is involved with ERK1/2 phosphorylation via PI3K.

TL;DR: This study suggests that the activation of AMPK signaling cascade participates in the promotion effect of gAd on CPT-1, a key regulator during beta-oxidation of fatty acids.

TL;DR: The total ghrelin plasma level in patients suffering from restrictive type of anorexia nervosa (AN-R) was significantly lower than in the control group before and after 3 and 6 months of therapy.

TL;DR: It is demonstrated that although disturbed apelin-APJ signalling in heart may play a role in the pathophysiology of heart failure, circulating apelin levels cannot be applied in the clinical assessment of patients with chronic left ventricular dysfunction.

TL;DR: The lack of GIP amplification of the late insulin response to iv glucose develops alongside the deterioration of glucose tolerance in patients with CP, suggesting that the same may be true for the loss of the GIP effect in Patients with type 2 diabetes mellitus.

TL;DR: Decreased expression of the GIPR gene in subcutaneous fat tissue is associated with signs of insulin resistance in non-diabetic women with central obesity and demonstrates that fasting hyperinsulinemia is a possible negative regulator of G IPR gene expression in sub cutaneous fat.

TL;DR: Women showed significantly higher fasting leptin, heart rate and cardiac sympathetic activity, and lower insulin sensitivity, suggesting that leptin in women is associated with SNS activity, compared with men, who showed no SNS relationship with insulin resistance.

TL;DR: Results indicate that kallikrein through kinin B2 receptor activation prevents apoptosis, inflammation and ventricular remodeling by increased nitric oxide formation and suppression of oxidative stress-mediated signaling pathways.

TL;DR: It is proposed that terguride may have beneficial effects in the treatment of diseases such as carcinoid syndrome, where serotonin plays an important pathogenic role.

TL;DR: Results showed that commitment of MSCs into osteogenic or adipogenic lineages is regulated by OGP(10-14), which suggests that bone marrow mesenchymal stem cells are multipotent cells capable of differentiating to osteogenic and adipogenic linesages when stimulated under appropriate conditions.

TL;DR: The hypothesis that Mas is able to rescue binding and functionality of the defective C18F-K20A mutant by dimerization support the hypothesis that a heterodimeration AT(1)/Mas could result in a functional interaction between both receptors.

TL;DR: The results show that orexin A increases the sympathetic firing rate, IBAT, colonic temperatures and heart rate in the rats pre-treated with saline, and this increase is blocked by the pre-treatment with 6- OHDA alone or 6-OHDA plus desipramine.