Research Journal of Pharmacy and Technology
A and V Publication
About: Research Journal of Pharmacy and Technology is an academic journal published by A and V Publication. The journal publishes majorly in the area(s): Drug delivery & DPPH. It has an ISSN identifier of 0974-3618. Over the lifetime, 3900 publications have been published receiving 18544 citations.
TL;DR: The present review focuses on various manufacturing and formulation perspectives and application of nanosuspension as drug delivery system.
Abstract: An increasing number of newly developed drugs are poorly soluble, in many cases drugs are poorly soluble in both aqueous and organic media excluding the traditional approaches to overcoming such solubility factors and resulting in bioavailability problem. An alternative and promising approach is the production of drug nanoparticles (nanosuspensions) to overcome these problems. Techniques such as media milling and high pressure homogenization have been used commercially for producing nanosuspensions. Nanosuspension can be delivered by various routes such as oral, parenteral, pulmonary and ocular system. It also possible to convert nanosuspension to patient-acceptable dosage forms like tablet, capsule and lyophilized powder products. The present review focuses on various manufacturing and formulation perspectives and application of nanosuspension as drug delivery system.
TL;DR: The floating or hydrodynamically controlled drug delivery systems are useful in such application and are addressed briefly about in the present review.
Abstract: Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 hours. The floating or hydrodynamically controlled drug delivery systems are useful in such application. The present review addresses briefly about the floating drug delivery systems.
TL;DR: In this article, solid dispersions are divided into six types based on their molecular arrangement: Eutectics (crystalline drug in crystalline matrix), amorphous precipitations in amorphous matrix, glass suspensions, glass solvers, glass solutions and glass solutions.
Abstract: Solid dispersion can be defined as “The dispersion of one or more active ingredients in an inert carrier or matrix at solid state”. Solid dispersions are prepared with an aim to improve the solubility and dissolution rate. Polyethylene Glycols (PEG4000, PEG6000and PEG8000), Polyvinyl pyrrolidone (PVP) used as polymers in the preparation of solid dispersions. Chloroform, Ethanol, Methanol is used as the solvents. The method of preparation of solid dispersions include Fusion method, hot melt extrusion, Solvent evaporation method, super critical fluid method, Dielectrostatic spinning process. Solid dispersions are divided into six types based on their molecular arrangement. They are Eutectics (crystalline drug in crystalline matrix),Amorphous precipitations in crystalline matrix (crystalline drug in amorphous matrix),Solid solutions (crystalline drug molecularly dispersed in matrix), Glass suspensions (crystalline drug in amorphous matrix),Glass suspensions (amorphous drug in amorphous matrix),Glass solutions (amorphous drug molecularly dispersed in matrix). Thin Layer Chromatography and Infra Red spectral analysis confirms the absence of interaction between the drug and the carriers. A marked improvement in the dissolution rate was observed in all the solid dispersions compared with the pure drug.900ml of 0.1M pH 7.4 phosphate buffer used as dissolution medium. The stirrer is adjusted to 75 rpm at 37°C and absorbance is measured by using UV-vis spectrophotometer.
TL;DR: In this article, a review of the production of solid dispersions, various carriers used and the advantageous properties of solid dispersion is presented. But, the authors do not consider the use of liquid dispersions in the formulation of drugs.
Abstract: Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor water solubility. The solubility behaviour of drugs remains one of the most challenging aspects in formulation development. Solid dispersions have tremendous potential for improving drug solubility. The present review is devoted to production of solid dispersions, various carriers used and the advantageous properties of solid dispersion.
TL;DR: It was concluded from the result that the hydroalcoholic extract of Aerva lanata possesses hepatoprotective activity against paracetamol induced hepatotoxicity in rats.
Abstract: The present study was conducted to evaluate the hepatoprotective activity of hydroalcoholic extract of Aerva lanata against paracetamol induced liver damage in rats The hydroalcoholic extract of Aerva lanata (600mg/kg) was administered orally to the animals with hepatotoxicity induced by paracetamol (3gm/kg) Silymarin (25mg/kg) was given as reference standard All the test drugs were administered orally by suspending in 05% Carboxy methyl cellulose solution The plant extract was effective in protecting the liver against the injury induced by paracetamol in rats This was evident from significant reduction in serum enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin It was concluded from the result that the hydroalcoholic extract of Aerva lanata possesses hepatoprotective activity against paracetamol induced hepatotoxicity in rats