Revista De Investigacion Clinica 

About: Revista De Investigacion Clinica is an academic journal published by Permanyer. The journal publishes majorly in the area(s): Population & Medicine. It has an ISSN identifier of 0034-8376. It is also open access. Over the lifetime, 2589 publications have been published receiving 18309 citations. The journal is also known as: Clinical and translational investigation.

Idiopathic pulmonary fibrosis

Abstract: Masculino de 60 anos, exfumador (tabaquismo por espacio de 10 anos consumiendo 10 cigarros al dia, el cual suspendio hace 30 anos). Sin antecedentes heredofamiliares ni personales de importancia. Sin evidencia de exposicion laboral o ambiental con excepcion del tabaquismo. Inicia su padecimiento actual hace un ano y medio con tos seca en accesos, habitualmente relacionada con el esfuerzo. Un ano antes de consultar se agrega disnea de esfuerzo la que progreso de los grandes a los medianos esfuerzos, sin ortopnea. A la exploracion fisica de torax se auscultaron estertores crepitantes sub-escapulares bilaterales, y ruidos cardiacos ritmicos con reforzamiento del segundo ruido en foco pulmonar. Presenta hipocratismo digital, sin cianosis y sin edemas de miembros pelvicos

Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). 1983.

Abstract: A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTVL), but claearly distinct from each previous isolate has been isolated from a Caucasian patient with signs and symptoms that often precede the acquired imune deficiency syndrome (AIDS). This virus is a thypical type-C RNA tumor virus, buds from the cell membrace, prefers magnesium for reseve transcriptase activity, an has an internal antigen (p25) similar to HTVL p24. Antibodies from serum of this patient react with proteins from viruses of the HTVL-1 subgroup, but type-specific antisera to HTVL-1 do not precipitate proteins of the new isolate. The virus from this patient has been transmitted into cord blood lymphocytes, and the virus pruduced by these cell is similar to the original isolate. From these sudies it is conclude that this virus as the previous HTVL isolate belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in human and may be involved in several pathological syndromes, including AIDS

The Role of Immunosenescence in the Development of Age-Related Diseases

Abstract: Aging is a complex phenomenon leading to numerous changes in the physiological systems of the body. One of the most important changes, called immunosenescence, occurs in the immune system. Immunosenescence covers changes in the innate and the adaptive immune systems and is associated with a low-grade inflammation called inflammaging. Aging, likely via inflammaging, is also associated with the emergence of chronic diseases including cardiovascular and neurodegenerative diseases, cancer, and diabetes mellitus type 2. The origin of this inflammaging is not known with certainty, but several concurrent contributing factors have been suggested, such as aging-associated changes in the innate and adaptive immune response, chronic antigenic stimulation, the appearance of endogenous macromolecular changes, and the presence of senescent cells exhibiting a senescence-associated secretory phenotype. A better understanding of the multiple biological phenomena leading to these diseases via the immunosenescence associated with inflammaging provides a powerful target for interventions to increase the healthspan of elderly subjects.