Showing papers in "RSC Advances in 2020"
TL;DR: Graphene and graphene oxide have attracted tremendous interest over the past decade due to their unique and excellent electronic, optical, mechanical, and chemical properties as discussed by the authors, and a review focusing on the functional modification of GAs is presented in this paper.
Abstract: Graphene and graphene oxide have attracted tremendous interest over the past decade due to their unique and excellent electronic, optical, mechanical, and chemical properties. This review focuses on the functional modification of graphene and graphene oxide. First, the basic structure, preparation methods and properties of graphene and graphene oxide are briefly described. Subsequently, the methods for the reduction of graphene oxide are introduced. Next, the functionalization of graphene and graphene oxide is mainly divided into covalent binding modification, non-covalent binding modification and elemental doping. Then, the properties and application prospects of the modified products are summarized. Finally, the current challenges and future research directions are presented in terms of surface functional modification for graphene and graphene oxide.
503 citations
TL;DR: A comprehensive overview of top prescribed drugs containing nitrogen heterocycles, describing their pharmacological properties, medical applications and their selected synthetic pathways is presented in this paper, where the reported examples are actually limited to current top selling drugs and their synthetic information has been extracted from both scientific journals and the wider patent literature.
Abstract: Heteroatoms as well as heterocyclic scaffolds are frequently present as the common cores in a plethora of active pharmaceuticals natural products. Statistically, more than 85% of all biologically active compounds are heterocycles or comprise a heterocycle and most frequently, nitrogen heterocycles as a backbone in their complex structures. These facts disclose and emphasize the vital role of heterocycles in modern drug design and drug discovery. In this review, we try to present a comprehensive overview of top prescribed drugs containing nitrogen heterocycles, describing their pharmacological properties, medical applications and their selected synthetic pathways. It is worth mentioning that the reported examples are actually limited to current top selling drugs, being or containing N-heterocycles and their synthetic information has been extracted from both scientific journals and the wider patent literature.
271 citations
TL;DR: In this paper, the synthesis methods of GQDs and CQDs have been summarized and their characterization methods also been analyzed, and issues and challenges of the carbon-based QDs were analyzed for their further development.
Abstract: Neuro-transmitters have been considered to be essential biochemical molecules, which monitor physiological and behavioral function in the peripheral and central nervous systems. Thus, it is of high pharmaceutical and biological significance to analyze neuro-transmitters in the biological samples. So far, researchers have devised a lot of techniques for assaying these samples. It has been found that electro-chemical sensors possess features of robustness, selectivity, and sensitivity as well as real-time measurement. Graphene quantum dots (GQDs) and carbon QDs (CQDs) are considered some of the most promising carbon-based nanomaterials at the forefront of this research area. This is due to their characteristics including lower toxicity, higher solubility in various solvents, great electronic features, strong chemical inertness, high specific surface areas, plenty of edge sites for functionalization, and versatility, in addition to their ability to be modified via absorbent surface chemicals and the addition of modifiers or nano-materials. Hence in the present review, the synthesis methods of GQDs and CQDs has been summarized and their characterization methods also been analyzed. The applications of carbon-based QDs (GQDs and CQDs) in biological and sensing areas, such as biological imaging, drug/gene delivery, antibacterial and antioxidant activity, photoluminescence sensors, electrochemiluminescence sensors and electrochemical sensors, have also been discussed. This study then covers sensing features of key neurotransmitters, including dopamine, tyrosine, epinephrine, norepinephrine, serotonin and acetylcholine. Hence, issues and challenges of the GQDs and CQDs were analyzed for their further development.
267 citations
TL;DR: Although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage.
Abstract: Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal carriers, nanolipid dispersions (liposomes, deformable liposomes, virosomes, ethosomes, and solid lipid nanoparticles) are ideal delivery systems with the advantages of biodegradation and nontoxicity. Among them, nano-structured lipid carriers and solid lipid nanoparticles (SLNs) are dominant, which can be modified to exhibit various advantages, compared to liposomes and polymeric nanoparticles. Nano-structured lipid carriers and SLNs are non-biotoxic since they are biodegradable. Besides, they are highly stable. Their (nano-structured lipid carriers and SLNs) morphology, structural characteristics, ingredients used for preparation, techniques for their production, and characterization using various methods are discussed in this review. Also, although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage.
222 citations
TL;DR: In this paper, an efficient, environmentally friendly, and simple approach for the green synthesis of ZnO nanoparticles (ZnO NPs) using orange fruit peel extract was presented.
Abstract: This paper presents an efficient, environmentally friendly, and simple approach for the green synthesis of ZnO nanoparticles (ZnO NPs) using orange fruit peel extract This approach aims to both minimize the use of toxic chemicals in nanoparticle fabrication and enhance the antibacterial activity and biomedical applications of ZnO nanoparticles In this work, an aqueous extract of orange peel was used as the biological reduction agent for the synthesis of ZnO NPs from zinc acetate dihydrate It was found that the size and morphology of the ZnO NPs significantly depended on physicochemical parameters such as the annealing temperature and pH during NP synthesis The ZnO NPs exhibited strong antibacterial activity toward Escherichia coli (E coli) and Staphylococcus aureus (S aureus) without UV illumination at an NP concentration of 0025 mg mL−1 after 8 h of incubation In particular, the bactericidal activity towards S aureus varied extensively with the synthesis parameters This study presents an efficient green synthesis route for ZnO NPs with a wide range of potential applications, especially in the biomedical field
167 citations
TL;DR: In this article, the authors summarize and organize the current development in super-tough PLA fabricated via polymer blending and analyze the properties of PLA-based blends and their morphological parameters, including particle size, interparticle distance, and phase morphologies.
Abstract: Poly(lactic acid) or poly(lactide) (PLA) is a renewable, bio-based, and biodegradable aliphatic thermoplastic polyester that is considered a promising alternative to petrochemical-derived polymers in a wide range of commodity and engineering applications. However, PLA is inherently brittle, with less than 10% elongation at break and a relatively poor impact strength, which limit its use in some specific areas. Therefore, enhancing the toughness of PLA has been widely explored in academic and industrial fields over the last two decades. This work aims to summarize and organize the current development in super tough PLA fabricated via polymer blending. The miscibility and compatibility of PLA-based blends, and the methods and approaches for compatibilized PLA blends are briefly discussed. Recent advances in PLA modified with various polymers for improving the toughness of PLA are also summarized and elucidated systematically in this review. Various polymers used in toughening PLA are discussed and organized: elastomers, such as petroleum-based traditional polyurethanes (PUs), bio-based elastomers, and biodegradable polyester elastomers; glycidyl ester compatibilizers and their copolymers/elastomers, such as poly(ethylene-co-glycidyl methacrylate) (EGMA), poly(ethylene-n-butylene-acrylate-co-glycidyl methacrylate) (EBA-GMA); rubber; petroleum-based traditional plastics, such as PE and PP; and various biodegradable polymers, such as poly(butylene adipate-co-terephthalate) (PBAT), polycaprolactone (PCL), poly(butylene succinate) (PBS), and natural macromolecules, especially starch. The high tensile toughness and high impact strength of PLA-based blends are briefly outlined, while the super tough PLA-based blends with impact strength exceeding 50 kJ m−2 are elucidated in detail. The toughening strategies and approaches of PLA based super tough blends are summarized and analyzed. The relationship of the properties of PLA-based blends and their morphological parameters, including particle size, interparticle distance, and phase morphologies, are presented.
164 citations
TL;DR: The focus is laid on the biosynthesis method, which makes the cerium oxide nanoparticle less toxic and compatible with the living tissues, which helps them to find their path as an anticancer, anti-inflammatory and antibacterial agents.
Abstract: Nanotechnology is the branch of science which deals with particles ranging between 1–100 nm. These particles are called nanoparticles, and they exhibit unique electronic, optical, magnetic, and mechanical properties, which make them different from the bulk material. These properties of nanomaterials help them to find a variety of applications in the biomedical, agricultural, and environmental domains. Cerium oxide nanoparticles have gained a lot of attention as a potential future candidate for ending various kinds of problems by exhibiting redox activity, free radical scavenging property, biofilm inhibition, etc. Synthesis of these nanoparticles can be performed very easily by utilizing chemical or biological methods. But in this review, the focus is laid on the biosynthesis of these nanoparticles; as the biosynthesis method makes the cerium oxide nanoparticle less toxic and compatible with the living tissues, which helps them to find their path as an anticancer, anti-inflammatory and antibacterial agents. The pre-existing reviews have only focused on details relating to properties/applications/synthesis; whereas this review draws attention towards all the aspects in single review covering all the details in depth such as biosynthesis methods and its effect on the living tissues, along with properties, biomedical applications (diagnostic and therapeutic) and future outlook of the cerium oxide nanoparticle.
148 citations
TL;DR: In this paper, the authors provide a brief introduction to TMD-based photodetectors, exclusively focused on MoS2-based 2D TMDs, and analyze the factors affecting the figure of merit of a very wide range of MoS 2-based heterostructures in terms of their photoresponsivity, detectivity, response speed, and quantum efficiency along with their measurement wavelengths and incident laser power densities.
Abstract: Two-dimensional transition metal dichalcogenides (2D TMDs) have attracted much attention in the field of optoelectronics due to their tunable bandgaps, strong interaction with light and tremendous capability for developing diverse van der Waals heterostructures (vdWHs) with other materials. Molybdenum disulfide (MoS2) atomic layers which exhibit high carrier mobility and optical transparency are very suitable for developing ultra-broadband photodetectors to be used from surveillance and healthcare to optical communication. This review provides a brief introduction to TMD-based photodetectors, exclusively focused on MoS2-based photodetectors. The current research advances show that the photoresponse of atomic layered MoS2 can be significantly improved by boosting its charge carrier mobility and incident light absorption via forming MoS2 based plasmonic nanostructures, halide perovskites–MoS2 heterostructures, 2D–0D MoS2/quantum dots (QDs) and 2D–2D MoS2 hybrid vdWHs, chemical doping, and surface functionalization of MoS2 atomic layers. By utilizing these different integration strategies, MoS2 hybrid heterostructure-based photodetectors exhibited remarkably high photoresponsivity raging from mA W−1 up to 1010 A W−1, detectivity from 107 to 1015 Jones and a photoresponse time from seconds (s) to nanoseconds (10−9 s), varying by several orders of magnitude from deep-ultraviolet (DUV) to the long-wavelength infrared (LWIR) region. The flexible photodetectors developed from MoS2-based hybrid heterostructures with graphene, carbon nanotubes (CNTs), TMDs, and ZnO are also discussed. In addition, strain-induced and self-powered MoS2 based photodetectors have also been summarized. The factors affecting the figure of merit of a very wide range of MoS2-based photodetectors have been analyzed in terms of their photoresponsivity, detectivity, response speed, and quantum efficiency along with their measurement wavelengths and incident laser power densities. Conclusions and the future direction are also outlined on the development of MoS2 and other 2D TMD-based photodetectors.
147 citations
TL;DR: A review of the latest synthesis routes of various types of catalysts (including acidic, basic, bifunctional and nanocatalysts) derived from different chemicals, as well as biomass is presented in this paper.
Abstract: An ever-increasing energy demand and environmental problems associated with exhaustible fossil fuels have led to the search for an alternative renewable source of energy. In this context, biodiesel has attracted attention worldwide as an eco-friendly alternative to fossil fuel for being renewable, non-toxic, biodegradable, and carbon-neutral. Although the homogeneous catalyst has its own merits, much attention is currently paid toward the chemical synthesis of heterogeneous catalysts for biodiesel production as it can be tuned as per specific requirement and easily recovered, thus enhancing reusability. Recently, biomass-derived heterogeneous catalysts have risen to the forefront of biodiesel productions because of their sustainable, economical and eco-friendly nature. Furthermore, nano and bifunctional catalysts have emerged as a powerful catalyst largely due to their high surface area, and potential to convert free fatty acids and triglycerides to biodiesel, respectively. This review highlights the latest synthesis routes of various types of catalysts (including acidic, basic, bifunctional and nanocatalysts) derived from different chemicals, as well as biomass. In addition, the impacts of different methods of preparation of catalysts on the yield of biodiesel are also discussed in details.
144 citations
TL;DR: Graphene quantum dots (GQDs) are an attractive nanomaterial consisting of a monolayer or a few layers of graphene having excellent and unique properties as mentioned in this paper.
Abstract: Graphene quantum dots (GQDs) are an attractive nanomaterial consisting of a monolayer or a few layers of graphene having excellent and unique properties GQDs are endowed with the properties of both carbon dots (CDs) and graphene This review addresses applications of GQD based materials in sensing, bioimaging and energy storage In the first part of the review, different approaches of GQD synthesis such as top-down and bottom-up synthesis methods have been discussed The prime focus of this review is on green synthesis methods that have also been applied to the synthesis of GQDs The GQDs have been discussed thoroughly for all the aspects along with their potential applications in sensors, biomedicine, and energy storage systems In particular, emphasis is given to popular applications such as electrochemical and photoluminescence (PL) sensors, electrochemiluminescence (ECL) sensors, humidity and gas sensors, bioimaging, lithium-ion (Li-ion) batteries, supercapacitors and dye-sensitized solar cells Finally, the challenges and the future perspectives of GQDs in the aforementioned application fields have been discussed
142 citations
TL;DR: The use of nanomaterials can be used to reinforce mechanical strength, enhance gas barrier properties, increase water repellence, and provide antimicrobial and scavenging activity to food packaging as mentioned in this paper.
Abstract: The rapid advancement of nanotechnology has provided opportunities for the development of new sensing and food packaging solutions, addressing long-standing challenges in the food sector to extend shelf-life, reduce waste, assess safety and improve the quality of food. Nanomaterials can be used to reinforce mechanical strength, enhance gas barrier properties, increase water repellence, and provide antimicrobial and scavenging activity to food packaging. They can be incorporated in chemical and biological sensors enabling the design of rapid and sensitive devices to assess freshness, and detect allergens, toxins or pathogenic contaminants. This review summarizes recent studies on the use of nanomaterials in the development of: (1) (bio)sensing technologies for detection of nutritional and non-nutritional components, antioxidants, adulterants and toxicants, (2) methods to improve the barrier and mechanical properties of food packaging, and (3) active functional packaging. The environmental, health and safety implications of nanomaterials in the food sector, along with an overview of regulation and consumer perception is also provided.
TL;DR: The review lays emphasis on the significance of 1,2,3-triazoles synthesized via CuAAC reaction having potential to act as anti-microbial, anti-cancer, anti’viral,Anti-inflammatory,anti-tuberculosis, pro-diabetic, and anti-Alzheimer drugs.
Abstract: The review lays emphasis on the significance of 1,2,3-triazoles synthesized via CuAAC reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory, anti-tuberculosis, anti-diabetic, and anti-Alzheimer drugs. The importance of click chemistry is due to its ‘quicker’ methodology that has the capability to create complex and efficient drugs with high yield and purity from simple and cheap starting materials. The activity of different triazolyl compounds was compiled considering MIC, IC50, and EC50 values against different species of microbes. In addition to this, the anti-oxidant property of triazolyl compounds have also been reviewed and discussed.
TL;DR: Natural products can play an important role in COVID-19 chemotherapy development and should be considered as a raw material for further development.
Abstract: COVID-19 is a viral disease caused by a new severe acute respiratory syndrome (SARS-CoV-2), which has quickly resulted in a pandemic. As a great threat to global public health, the development of a treatment has become vital, and a rush to find a cure has mobilized researchers from all areas across the world. Synthetic drugs, such as hydroxychloroquine, have gained attention. However, the efficacy of repositioned drugs is still under evaluation, and besides, some severe side effects are a cause for concern. This emphasizes the urgency for treatment options, which can be both safe and effective. With this in mind, natural products could be an important resource in the development of COVID-19 treatment, as they have already contributed in the past to treatments against other viruses, such as HIV, MERS-CoV, and influenza. Natural products are described long term as bioactive substances and some phytochemical classes such as flavonoids, alkaloids, and peptides are known antiviral bioproducts, and have been virtually tested with success against COVID-19. However, important issues still need to be addressed as to their bioavailability and true efficacy in vivo. This review intends to systematically evaluate the natural metabolites that could potentially be used against this new disease looking at their natural sources, mechanism of action and previous pharmacological usages. The aim is to provide a starting point for this research area in order to speed up the establishment of anti-SARS-CoV-2 bioproducts.
TL;DR: In this article, the value of metal resources in the printed circuit boards (PCBs) commonly found in end-of-life electronics, the differences between primary (ore) mining applications and secondary (urban) mining, and the variety of metallurgical separations, in particular those that have the potential to selectively and sustainably recover gold from waste PCBs, are highlighted.
Abstract: Rapid global technological development has led to the rising production of electronic waste that presents both challenges and opportunities in its recycling. In this review, we highlight the value of metal resources in the printed circuit boards (PCBs) commonly found in end-of-life electronics, the differences between primary (ore) mining applications and secondary (‘urban’) mining, and the variety of metallurgical separations, in particular those that have the potential to selectively and sustainably recover gold from waste PCBs.
TL;DR: Graph neural networks are introduced to obtain their representations, and a method called DGraphDTA is proposed for DTA prediction, which could predict the structural characteristics of the protein according to its sequence.
Abstract: Computer-aided drug design uses high-performance computers to simulate the tasks in drug design, which is a promising research area. Drug–target affinity (DTA) prediction is the most important step of computer-aided drug design, which could speed up drug development and reduce resource consumption. With the development of deep learning, the introduction of deep learning to DTA prediction and improving the accuracy have become a focus of research. In this paper, utilizing the structural information of molecules and proteins, two graphs of drug molecules and proteins are built up respectively. Graph neural networks are introduced to obtain their representations, and a method called DGraphDTA is proposed for DTA prediction. Specifically, the protein graph is constructed based on the contact map output from the prediction method, which could predict the structural characteristics of the protein according to its sequence. It can be seen from the test of various metrics on benchmark datasets that the method proposed in this paper has strong robustness and generalizability.
TL;DR: The droplet-based microfluidic systems have been shown to be compatible with many chemical and biological reagents and capable of performing a variety of operations that can be rendered programmable and reconfigurable as mentioned in this paper.
Abstract: Droplet-based microfluidic systems have been shown to be compatible with many chemical and biological reagents and capable of performing a variety of operations that can be rendered programmable and reconfigurable. This platform has dimensional scaling benefits that have enabled controlled and rapid mixing of fluids in the droplet reactors, resulting in decreased reaction times. This, coupled with the precise generation and repeatability of droplet operations, has made the droplet-based microfluidic system a potent high throughput platform for biomedical research and applications. In addition to being used as micro-reactors ranging from the nano- to femtoliter (10−15 liters) range; droplet-based systems have also been used to directly synthesize particles and encapsulate many biological entities for biomedicine and biotechnology applications. For this, in the following article we will focus on the various droplet operations, as well as the numerous applications of the system and its future in many advanced scientific fields. Due to advantages of droplet-based systems, this technology has the potential to offer solutions to today's biomedical engineering challenges for advanced diagnostics and therapeutics.
TL;DR: A review of wearable electrochemical potentiometric pH sensors can be found in this article, covering the key topics such as suitability of pH sensors in wearable systems, designs of flexible pH sensors, which may vary with target applications, materials for various components of the sensor such as substrates, reference and sensitive electrode.
Abstract: There is a growing demand for developing wearable sensors that can non-invasively detect the signs of chronic diseases early on to possibly enable self-health management. Among these the flexible and stretchable electrochemical pH sensors are particularly important as the pH levels influence most chemical and biological reactions in materials, life and environmental sciences. In this review, we discuss the most recent developments in wearable electrochemical potentiometric pH sensors, covering the key topics such as (i) suitability of potentiometric pH sensors in wearable systems; (ii) designs of flexible potentiometric pH sensors, which may vary with target applications; (iii) materials for various components of the sensor such as substrates, reference and sensitive electrode; (iv) applications of flexible potentiometric pH sensors, and (v) the challenges relating to flexible potentiometric pH sensors.
TL;DR: In this article, the annealing effect on the structural, elastic, thermodynamic, optical, magnetic, and electric properties of Ni0.6Zn0.4Fe1.5O4 (NZFAO) nanoparticles was presented.
Abstract: This article presents the annealing effect on the structural, elastic, thermodynamic, optical, magnetic, and electric properties of Ni0.6Zn0.4Fe1.5Al0.5O4 (NZFAO) nanoparticles (NPs). The samples were successfully synthesized by the sol–gel method followed by annealing of the as-synthesized at 600, 800, 900, 1050, and 1200 °C. This approach yielded the formation of a highly crystalline structure with crystallite size ranging from 17 nm to 40 nm. X-ray diffraction (XRD), scanning electron microscopy (SEM) techniques, as well as energy disperse spectroscopy (EDS), Fourier transform infrared (FTIR) and Raman spectroscopy, were used in order to determine the structural and morphological properties of the prepared samples. Rietveld XRD refinement reveals that Ni–Zn–Al ferrite nanoparticles crystallize in inverse cubic (Fdm) spinel structure. Using FTIR spectra, the elastic and thermodynamic properties were estimated. It was observed that the particle size had a pronounced effect on elastic and thermodynamic properties. Magnetic measurements were performed up to 700 K. The prepared ferrite samples present the highest Curie temperature, which decreases with increasing particle size and which is consistent with finite-size scaling. The thickness of the surface shell of about 1 nm was estimated from size-dependent magnetization measurements using the core–shell model. Besides, spin resonance, magnetostriction, temperature coefficient of resistance (TCR), and electrical resistivity properties have been scientifically studied and appear to be different according to their size. The optical properties of synthesized NZFAO nanoparticles were investigated, and the differences caused by the particle sizes are discussed on the basis of the phonon confinement effect. This effect was also inspected by the Raman analysis. Tuning of the physical properties suggests that the Ni–Zn–Al ferrite samples may be promising for multifunctional diverse applications.
TL;DR: In this paper, a review article explores typical recent applications of conductive polymers (2016-2020) as active electrode materials for energy storage applications, electrochemical sensing, and conversion fields such as electrochemical supercapacitors, lithium-ion batteries, fuel cells, and solar cells.
Abstract: Scientists have categorized conductive polymers as materials having strongly reversible redox behavior and uncommon combined features of plastics and metal. Because of their multifunctional characteristics, e.g., simplistic synthesis, acceptable environmental stability, beneficial optical, electronic, and mechanical features, researchers have largely considered them for diverse applications. Therefore, their capability of catalyzing several electrode reactions has been introduced as one of their significant features. A thin layer of the conducting polymer deposited on the substrate electrode surface can augment the electrode process kinetics of several solution species. Such electrocatalytic procedures with modified conducting polymer electrodes can create beneficial utilization in diverse fields of applied electrochemistry. This review article explores typical recent applications of conductive polymers (2016–2020) as active electrode materials for energy storage applications, electrochemical sensing, and conversion fields such as electrochemical supercapacitors, lithium-ion batteries, fuel cells, and solar cells.
TL;DR: The three main light emitting mechanisms (PET, ICT, FRET) of fluorescent probes are introduced, and some probes based on this light emitting mechanism are enumerated.
Abstract: In recent years, the research on fluorescent probes has developed rapidly. Coumarin fluorescent probes have also been one of the hot topics in recent years. For the synthesis and application of coumarin fluorescent probes, great progress has been made. Coumarin fluorescent probes have become more and more widely used in biochemistry, environmental protection, and disease prevention, and have broad prospects. This review introduces the three main light emitting mechanisms (PET, ICT, FRET) of fluorescent probes, and enumerates some probes based on this light emitting mechanism. In terms of the synthesis of coumarin fluorescent probes, the existing substituents on the core of coumarin compounds were modified. Based on the positions of the modified substituents, some of the fluorescent probes reported in the past ten years are listed. Most of the fluorescent probes are formed by modifying the 3 and 7 position substituents on the mother nucleus, and the 4 and 8 position substituents are relatively less modified. In terms of probe applications, the detection and application of coumarin fluorescent probes for Cu2+, Hg2+, Mg2+, Zn2+, pH, environmental polarity, and active oxygen and sulfide in the past ten years are mainly introduced.
TL;DR: In this paper, the authors review the recent progress of ZnO nanostructured materials in emerging solar cell applications, such as sensitized and heterojunction architectures, including those embedded with promising perovskite materials.
Abstract: Zinc oxide (ZnO) has been considered as one of the potential materials in solar cell applications, owing to its relatively high conductivity, electron mobility, stability against photo-corrosion and availability at low-cost. Different structures of ZnO materials have been engineered at the nanoscale, and then applied on the conducting substrate as a photoanode. On the other hand, the ZnO nanomaterials directly grown on the substrate have been attractive due to their unique electron pathways, which suppress the influence of surface states typically found in the former case. Herein, we review the recent progress of ZnO nanostructured materials in emerging solar cell applications, such as sensitized and heterojunction architectures, including those embedded with promising perovskite materials. The remarkable advancement in each solar cell architecture is highlighted towards achieving high power conversion efficiency and operational stability. We also discuss the foremost bottleneck for further improvements and the future outlook for large-scale practical applications.
TL;DR: Various selected quinolines and derivatives with potential biological and pharmaceutical activities will be presented and synthesis protocols used up to now for the construction of the principal quinoline scaffold are highlighted.
Abstract: Recently, quinoline has become an essential heterocyclic compound due to its versatile applications in the fields of industrial and synthetic organic chemistry. It is a vital scaffold for leads in drug discovery and plays a major role in the field of medicinal chemistry. Nowadays there are plenty of articles reporting syntheses of the main scaffold and its functionalization for biological and pharmaceutical activities. So far, a wide range of synthesis protocols have been reported in the literature for the construction of this scaffold. For example, Gould–Jacob, Friedlander, Pfitzinger, Skraup, Doebner–von Miller and Conrad–Limpach are well-known classical synthesis protocols used up to now for the construction of the principal quinoline scaffold. Transition metal catalysed reactions, metal-free ionic liquid mediated reactions, ultrasound irradiation reactions and green reaction protocols are also useful for the construction and functionalization of this compound. The main part of this review focuses on and highlights the above-mentioned synthesis procedures and findings to tackle the drawbacks of the syntheses and side effects on the environment. Furthermore, various selected quinolines and derivatives with potential biological and pharmaceutical activities will be presented.
TL;DR: Various nanocarriers, including nanodispersion systems, nanomicelles, lipidic nanoccarriers, polymeric nanoparticles, liposomes, niosomes, and dendrimers, have been investigated for improved permeation and effective targeted drug delivery to various ophthalmic sites.
Abstract: Ocular diseases have a significant effect on vision and quality of life. Drug delivery to ocular tissues is a challenge to formulation scientists. The major barriers to delivering drugs to the anterior and posterior segments include physiological barriers (nasolacrimal drainage, blinking), anatomical barriers (static and dynamic), efflux pumps and metabolic barriers. The static barriers comprise the different layers of the cornea, sclera, and blood–aqueous barriers whereas dynamic barriers involve conjunctival blood flow, lymphatic clearance and tear drainage. The tight junctions of the blood–retinal barrier (BRB) restrict systemically administered drugs from entering the retina. Nanocarriers have been found to be effective at overcoming the issues associated with conventional ophthalmic dosage forms. Various nanocarriers, including nanodispersion systems, nanomicelles, lipidic nanocarriers, polymeric nanoparticles, liposomes, niosomes, and dendrimers, have been investigated for improved permeation and effective targeted drug delivery to various ophthalmic sites. In this review, various nanomedicines and their application for ophthalmic delivery of therapeutics are discussed. Additionally, scale-up and clinical status are also addressed to understand the current scenario for ophthalmic drug delivery.
TL;DR: An overview of microwave assisted organic synthesis (MAOS) and its role in recent and pressing advancements for the synthesis of small and medium-sized nitrogen-containing heterocycles can be found in this article.
Abstract: Nitrogen containing heterocycles are of immense research interest because they are often found as naturally occurring bioactive compounds. The prominence of N-heterocycles makes it vital to develop methods to increase their synthetic efficiencies and probe the effects of their modifications on biological efficacy. Medicinal chemists have exploited microwave-assisted organic synthesis (MAOS) to facilitate the development of complex heterocyclic structures. MAOS is a growing synthetic methodology among medicinal chemists and has proven to be more efficient in terms of reaction yield, reaction time, product purity and environmental friendliness for many reactions when compared to conventional thermal methods for cycloaddition and selective functionalization. The importance of nitrogen containing ring systems in medicine cannot be understated, as such ring systems have shown to be applicable in compounds such as vitamins, herbicides, anti-fungal agents, anti-bacterial agents and anti-cancer agents, among other things. The significance of these applications has created an unprecedented need for more efficient synthetic methods. This review presents an overview of MAOS and its role in recent and pressing advancements for the synthesis of small- and medium-sized nitrogen containing heterocycles, including pyrroles, indoles, pyridines, pyrrolidines, imidazoles, pyrazoles, pyrazolines, lactams, and 1,2,3-triazoles, which are significant scaffolds for compounds with medicinal uses.
TL;DR: In this article, the authors discuss the nature and occurrence of tracycline (TC) residues in surface water and present an overview of the various advanced treatment techniques for TC removal.
Abstract: Tetracycline (TC), a frequently used drug for human and veterinary therapeutics, is among the most common antibiotic residues found in nature. Lack of advanced treatment techniques in the wastewater treatment plants (WWTPs) to remove residual TC from domestic and hospital wastewater poses a serious environmental risk. It is important to have an insight into the different advanced treatment techniques for efficient removal of TC from the surface water and in the WWTPs. The aim of this review is to discuss the nature and occurrence of TC in surface water and to present an overview of the various advanced treatment techniques for TC removal. The advanced treatment techniques include advanced oxidation processes (photolysis, ozonation, and catalytic/UV light-based degradation), membrane filtration, reverse osmosis, and adsorption techniques. Adsorption and integrated oxidation treatment techniques are the most widely studied methods, and they are widely accepted because of less cost, reusability, and toxic-free nature. Further, the uses of various types of catalysts for photodegradation and various sorbents for adsorption of TC are also presented. Finally, the importance of green nanocomposite for environmental sustainability in TC removal is emphasized.
TL;DR: In this article, the influence of the primary formulation parameters on the formation of poly-DL-lactic-co-glycolic nanoparticles by the emulsification-solvent evaporation, and the nanoprecipitation techniques was analyzed.
Abstract: This study presents the influence of the primary formulation parameters on the formation of poly-DL-lactic-co-glycolic nanoparticles by the emulsification-solvent evaporation, and the nanoprecipitation techniques. In the emulsification-solvent evaporation technique, the polymer and tensoactive concentrations, the organic solvent fraction, and the sonication amplitude effects were analyzed. Similarly, in the nanoprecipitation technique the polymer and tensoactive concentrations, the organic solvent fraction and the injection speed were varied. Additionally, the agitation speed during solvent evaporation, the centrifugation speeds and the use of cryoprotectants in the freeze-drying process were analyzed. Nanoparticles were characterized by dynamic light scattering, laser Doppler electrophoresis, and scanning electron microscopy, and the results were evaluated by statistical analysis. Nanoparticle physicochemical characteristics can be adjusted by varying the formulation parameters to obtain specific sizes and stable nanoparticles. Also, by adjusting these parameters, the nanoparticle preparation processes have the potential to be tuned to yield nanoparticles with specific characteristics while maintaining reproducible results.
TL;DR: Carbon nanotubes (CNTs) have been recognized as a promising material in a wide range of applications, from safety to energy-related devices as mentioned in this paper, but their poor solubility in aqueous and organic solvents has hindered the utilisation and applications of CNTs.
Abstract: Carbon nanotubes (CNTs) have been recognised as a promising material in a wide range of applications, from safety to energy-related devices. However, poor solubility in aqueous and organic solvents has hindered the utilisation and applications of carbon nanotubes. As studies progressed, the methodology for CNTs dispersion was established. The current state of research in CNTs either single wall or multiwall/polymer nanocomposites has been reviewed in context with the various types of functionalisation presently employed. Functionalised CNTs have been playing an increasingly central role in the research, development, and application of carbon nanotube-based nanomaterials and systems. The extremely high surface-to-volume ratio, geometry, and hollow structure of nanomaterials are ideal for the adsorption of gas molecules. This offers great potential applications, such as in gas sensor devices working at room temperature. Particularly, the advent of CNTs has fuelled the invention of CNT-based gas sensors which are very sensitive to the surrounding environment. The presence of O2, NH3, NO2 gases and many other chemicals and molecules can either donate or accept electrons, resulting in an alteration of the overall conductivity. Such properties make CNTs ideal for nano-scale gas-sensing materials. Conductive-based devices have already been demonstrated as gas sensors. However, CNTs still have certain limitations for gas sensor application, such as a long recovery time, limited gas detection, and weakness to humidity and other gases. Therefore, the nanocomposites of interest consisting of polymer and CNTs have received a great deal of attention for gas-sensing application due to higher sensitivity over a wide range of gas concentrations at room temperature compared to only using CNTs and the polymer of interest separately.
TL;DR: The process of chemical modification and/crosslinking of XG via etherification, esterification, acetalation, amidation, and oxidation is illustrated and the recent developments on XG derivatives are very promising to progress further with polysaccharide research.
Abstract: Natural polysaccharides are well known for their biocompatibility, non-toxicity and biodegradability. These properties are also inherent to xanthan gum (XG), a microbial polysaccharide. This biomaterial has been extensively investigated as matrices for tablets, nanoparticles, microparticles, hydrogels, buccal/transdermal patches, tissue engineering scaffolds with different degrees of success. However, the native XG has its own limitations with regards to its susceptibility to microbial contamination, unusable viscosity, poor thermal and mechanical stability, and inadequate water solubility. Chemical modification can circumvent these limitations and tailor the properties of virgin XG to fulfill the unmet needs of drug delivery, tissue engineering, oil drilling and other applications. This review illustrates the process of chemical modification and/crosslinking of XG via etherification, esterification, acetalation, amidation, and oxidation. This review further describes the tailor-made properties of novel XG derivatives and their potential application in diverse fields. The physicomechanical modification and its impact on the properties of XG are also discussed. Overall, the recent developments on XG derivatives are very promising to progress further with polysaccharide research.
TL;DR: This study provides a scientific basis for the health benefits of the regular use of S. persica as it leaches bioactive flavonoids in the aqueous saliva.
Abstract: In December 2019, an outbreak of coronavirus disease 2019 (COVID-19) commenced in Wuhan, China and affected around 210 countries and territories in a matter of weeks. It has a phylogenetic similarity to SARS-CoV and it was named coronavirus 2 (SARS-CoV-2) and caused severe acute respiratory syndrome that could lead to death. One of the promising therapeutic strategies for virus infection is the search for enzyme inhibitors among natural compounds using molecular docking in order to obtain products with minimal side effects. COVID-19 virus main protease plays a vital role in mediating viral transcription and replication, introducing it as an attractive antiviral agent target. Metabolic profiling of the aqueous extract of Salvadora persica L. (Salvadoraceae) aerial parts dereplicated eleven known flavonol glycosides using LC-HRESIMS. All the annotated flavonoids exhibited significant binding stability at the N3 binding site to different degrees, except isorhamnetin-3-O-β-D-glucopyranoside, when compared with the currently used COVID-19 main protease inhibitor, darunavir. Structural similarity between the identified flavonoids enabled the study of the relationship between their structure and interactions with the receptor in the N3 binding site of the COVID-19 main protease. The results indicate that the basic flavonol nucleus possesses activity itself. Moreover, the presence of a rutinose moiety at the 3 position of ring C and absence of an O-methyl group in ring B of the flavonol structure could increase the binding stability. This study provides a scientific basis for the health benefits of the regular use of S. persica as it leaches bioactive flavonoids in the aqueous saliva.
TL;DR: In this paper, the authors provide an overview of the long-term durability performance and degradation behavior under various aging environments (thermo-oxidative aging, accelerated weathering (ultraviolet aging), hydrolytic degradation, fatigue and creep, etc.) of commercially important biobased-composites for the first time.
Abstract: Global concerns over environmental issues have led to a tremendous growth in sustainable materials emerging from biobased plastics and their composites (biocomposites). This class of materials can be an alternative to traditional composite materials to reduce the carbon footprint and strain on the environment. Many studies and reviews have been focused on enhancing the mechanical performance of biocomposites with the aim for them to compete with traditional composites and expand their applications. However, the current scientific knowledge relating to the long-term durability performance of biocomposites is very limited in open access literature. Studies of the effects of different aging mechanisms when subjected to different service conditions and environments on the biocomposites' behaviours are needed. This review provides a focused discussion on the overview of the long-term durability performance and degradation behaviour under various aging environments (thermo-oxidative aging, accelerated weathering (ultraviolet aging), hydrolytic degradation, fatigue and creep, etc.) of the commercially important biobased-composites for the first time. Future perspectives and methods to improve the durability performance of biocomposites are also discussed in this review.