Showing papers in "Russian Chemical Bulletin in 2020"
TL;DR: The recent data (2007-2018) on the synthesis of thieno[2,3-b]pyridines are summarized and systematized in this paper.
Abstract: The recent data (2007–2018) on the synthesis of thieno[2,3-b]pyridines are summarized and systematized.
24 citations
TL;DR: In this paper, the catalytic activity of nickel bis-NHC complexes (NHC)2NiX2 (X = Cl, Br, or I) was evaluated in the cross-coupling reactions of aryl halides with aryboronic acids.
Abstract: Catalytic activity of nickel(ii) and palladium(ii) N-heterocyclic carbene (NHC) complexes derived from imidazole, benzimidazole, and 1,2,4-triazole was comparatively evaluated in the cross-coupling reactions of aryl halides with arylboronic acids. Readily available nickel bis-NHC complexes (NHC)2NiX2 (X = Cl, Br, or I) exhibited the activity comparable to that of the structurally related palladium complexes and, consequently, can be applied as efficient catalysts for the Suzuki—Miyaura reaction.
23 citations
TL;DR: In this article, a free impinging-jets microreactor was used to synthesize gadolinium orthoferrite (GdFeO3) nanoparticles for contrast agents for magnetic resonance imaging (MRI).
Abstract: Gadolinium orthoferrite GdFeO3 nanoparticles were synthesized by co-precipitation of gadolinium and iron(m) hydroxides in a free impinging-jets microreactor followed by thermal treatment of co-precipitation products. According to X-ray diffraction, the co-precipitated hydroxides were X-ray amorphous, and the content of key elements within their composition corresponded to the stoichiometry of GdFeO3. Powder X-ray diffraction of the product of thermal treatment of hydroxides at 750 °C for 4 h indicated on the formation of GdFeO3 nanocrystals with a perovskite-like orthorhombic structure and an average crystallite size of 27±3 nm. Scanning electron microscopy showed that the gadolinium orthoferrite nanocrystals had an isometric morphology, and their specific surface area was determined by the Brunauer—Emmett—Teller method to be 13.55 m2g−1. Mossbauer spectroscopy and vibrational magnetometry showed that the obtained GdFeO3 nanoparticles were superparamagnetic and were characterized by a bimodal distribution of the effective field, indicating on their core—shell-type composite structure. The study of the composition, structure, morphology, and magnetic behavior of the obtained gadolinium orthoferrite nanoparticles showed that they can be used as a basis for contrast agents for magnetic resonance imaging (MRI).
20 citations
TL;DR: In this paper, the effect of an increase in the relative content of imide units on the glass transition and melting temperatures of the crystalline phase of copolymers and mixed compositions is detected.
Abstract: Based on poly[di(ethylene glycol) adipate] (Mn = 2500) terminated by 2,4-toluene diiso-cyanate (TDI), bis(3´,4-dicarboxyphenoxy)benzene (dianhydride R), and 1,4-bis(4´-amino-phenoxy)biphenyl (diamine ODFO) a number of co-poly(urethane-imide) samples with the general formula (R-TDI-2500-TDI-R)(ODFO)n (n = 1–3, 5), differing in the content of aromatic blocks (from 37 to 65 wt.%) were obtained. The synthesized samples were characterized by the TGA, DSC, and DMA methods and were used to prepare mixed compositions with the known R-ODFO polyimide in two versions, namely, with a polyimide content of 10 and 90 wt.%. Mixed compositions were investigated by DSC. The effect of an increase in the relative content of imide units on the glass transition and melting temperatures of the crystalline phase of copolymers and mixed compositions is detected.
15 citations
TL;DR: The main advances in the synthesis and studies of new stable heterocyclic verdazyl radicals and their applications are reviewed in this paper, where promising applications of these radicals are also discussed.
Abstract: The main advances in the synthesis and studies of the properties of new stable heterocyclic verdazyl radicals and verdazyl radical coordination chemistry are reviewed. The promising applications of these radicals are also discussed.
15 citations
TL;DR: In this article, new hydroxy derivatives of chalcones obtained via a condensation of 3-acetyl-2H-chromen-2-one with 2,4-dihydroxy- and 4-hydroxy-benzaldehydes were isolated and characterized.
Abstract: New hydroxy derivatives of chalcones obtained via a condensation of 3-acetyl-2H-chromen-2-one with 2,4-dihydroxy- and 4-hydroxy-benzaldehydes and via an aldol crotonic condensation of methyl N-(4-acetylphenyl)carbamate with 4-hydroxy-3,5-di(tert-butyl)benzaldehyde have been isolated and characterized. A wide range of promising biological activity of the synthesized compounds, including the radical scavenging and antioxidant ones, was predicted by the in silico method. The anti- and pro-oxidant activities in model systems of peroxidation of cis-9-octadecenoic (oleic) acid and lipids from the liver homogenate of tilapia were estimated in vitro. The presence of sterically hindered hydroxy groups and a chromene moiety provides the prolonged antioxidant activity of new hydroxy derivatives of chalcones.
14 citations
TL;DR: In this paper, six new metal-organic frameworks based on magnesium(II) ions of various dimensionality were synthesized: chain-like [Mg(Hazdc)2(nmp)2] (1, H2azdc is 4,4′-azobenzenedicarboxylic acid, nmp is N-methylpyrrolidone), layered [mg3(H2btc)(nmp), H2sdc is 1,2,4,5-benzene-tetracarbox
Abstract: Six new metal-organic frameworks based on magnesium(II) ions of various dimensionality were synthesized: chain-like [Mg(Hazdc)2(nmp)2] (1, H2azdc is 4,4′-azobenzenedicarboxylic acid, nmp is N-methylpyrrolidone), layered [Mg(H2btc)(nmp)2] (2, H4btc is 1,2,4,5-benzene-tetracarboxylic acid), [Mg3(sdc)3(def)4] •3DEF (3, H2sdc is 4,4’-stilbenedicarboxylic acid, def or DEF is N,N-diethylformamide), [Mg3(azdc)3(dma)4] • 3DMA (4, dma or DMA is N,N-di-methylacetamide), [Mg3(azdc)3(dmf)4] (5, dmf is N,N-dimethylformamide), and doubly-interpenetrated three-dimensional [Mg3(azdc)3(nmp)4] •NMP (6, NMP is N-methylpyrrolidone). According to the single-crystal X-ray dif raction data, compounds 1 and 2 are built from mononuclear carboxylate units {Mg(RCOOH)2(RCOO)2(nmp)2}. Compounds 3-6 are composed on trinuclear carboxylate units {Mg3(RCOO)6}. In isostructural compounds 3-5, these units are linked to each other through carboxylate bridges to form polymer layers; in compound 6, these units are linked together to form a doubly-interpenetrated three-dimensional metal-organic framework.
14 citations
TL;DR: A systematic overview of the methods for the synthesis of benzimidazoles with a fluorinated benzene ring and applications of these compounds in practice can be found in this paper.
Abstract: The review presents a systematic overview of the methods for the synthesis of benzimidazoles with a fluorinated benzene ring and considers applications of these compounds in practice.
14 citations
TL;DR: The key options for the synthesis of functionalized pillararenes and their applications in electrochemical sensors and biosensors are considered in this article, where the macrocycle is used as an electron transfer mediator, a reactant for the formation of host-guest complexes, and a carrier of biochemical receptors.
Abstract: The key options for the synthesis of functionalized pillar[5]arenes and their applications in electrochemical sensors and biosensors are considered. Examples of using the macrocycle as an electron transfer mediator, a reactant for the formation of host—guest complexes, and a carrier of biochemical receptors are given. Details of behavior and ways of inclusion of pillararenes into the surface layer of electrochemical sensors are indicated. The trends of further development of pillararene chemistry are discussed as applied to the problems of advancement of electrochemical sensors.
13 citations
TL;DR: In this paper, a concept was formulated for the production of new systems for the prolonged release of drugs bearing a constant or temporary (protonated group positive charge and fluorescent labels for tissue staining during electrophoretic introduction.
Abstract: Synthetic approaches were proposed to the development of hybrid organic—inorganic systems based on giant Keplerate polyoxometalates (POM Mo132), biocompatible polymers, and fluorescent molecules. A concept was formulated for the production of new systems for the prolonged release of drugs bearing a constant or temporary (protonated group) positive charge and fluorescent labels for tissue staining during electrophoretic introduction. In particular, a possibility of covalent functionalization of the POM Mo132 surface by the organosilicon molecules (aminopropyltrimethoxysilane) was shown. A promising procedure of the synthesis of NHS-esters of rhodamine B for the subsequent inclusion into the hybrid system was developed. The kinetic studies of POM destruction in an aqueous medium were carried out. The influence of association of rhodamine B with Mo132 on the character of fluorescence was studied.
13 citations
TL;DR: In this article, the crystal structure prediction for two isomeric forms of tetrazino-tetrazine tetraoxide (TTTO) was performed using an original procedure to obtain the optimized point charges that approximate the molecular electrostatic potential.
Abstract: The crystal structure prediction for two isomeric forms of tetrazino-tetrazine tetraoxide (TTTO), viz., [1,2,3,4]tetrazino[5,6-e][1,2,3,4]tetrazine 1,3,6,8-tetraoxide and [1,2,3,4] tetrazino [5,6-e] [1,2,3,4] tetrazine 1,3,5,7-tetraoxide was performed using an original procedure to obtain the optimized point charges that approximate the molecular electrostatic potential. The best computational models were used for simulation of the crystal packing of the molecules within the framework of the atom-atom potential function method with the refined Lennard-Jones potential parameters (6-12) by optimizing the unit cell parameters and localizing the minima on the potential energy surfaces of the crystal structures.
TL;DR: In this article, two-step electrosynthesis of CoO-CoO•xH2O-supported metal nanoparticles (MNPs, M = Au, Ag, Pd) was carried out in N,N-dimethylformamide in the absence and in presence of poly(N-vinylpyrrolidone) (PVP) using atmospheric oxygen as both a reagent and a mediator at potentials of its reduction to a superoxide radical anion.
Abstract: Two-step electrosynthesis of CoO-CoO•xH2O-supported metal nanoparticles (MNPs, M = Au, Ag, Pd) was carried out in N,N-dimethylformamide in the absence and in presence of poly(N-vinylpyrrolidone) (PVP) using atmospheric oxygen as both a reagent and a mediator at potentials of its reduction to a superoxide radical anion. In the first step, oxygen reduction in the presence of Co2+ ions added to the solution as a salt or generated by dissolving the Co-anode during electrolysis produces a mixture of cobalt oxide CoO and its hydrated form CoO-CoO • xH2O (CoOxHy ). When Ag+, Au+, Pd2+ ions are added to the obtained solution of CoOx H y, a redox reaction between CoO and the metal ion gives the MNPs and CoO+. In the second step, oxygen-mediated electroreduction of CoO+ serving as the second mediator is carried out, and the redox reaction is completely shifted towards the formation of MNPs. In the absence of PVP, AgNPs (18±4 nm) bind and stabilize completely in the CoOxHy matrix, PdNPs (6±1 nm) stabilize only partially, and AuNPs (21±10 nm) do not bind and, therefore, only their agglomerates are obtained (~200 nm). In the presence of PVP, individual AgNPs (5±2 nm), AuNPs (13±5 nm), PdNPs (3±1 nm) are stabilized in the PVP shell and are bound by the matrix. The obtained nanocomposites M/CoOx H y and M@PVP/CoOxHy catalyze the reduction of p-nitrophenol with sodium borohydride in an aqueous medium. Their catalytic activity is due to MNPs; CoOx H y acts as an inert matrix.
TL;DR: In this article, the features of hydrogenation of carbon monoxide and carbon dioxide over the Fe-based Fe/C and FeK/C catalysts were studied, showing that the promotion of the iron-based catalyst on the carbon support with potassium at equal CO2 conversions leads to an increase in the chain growth probability (α) and in a significant increase of the selectivity to C5+ hydrocarbons, including olefins.
Abstract: The features of hydrogenation of carbon monoxide and carbon dioxide over the Fe-based Fe/C and FeK/C catalysts were studied. The promotion of the iron-based catalyst on the carbon support with potassium at equal CO2 conversions leads to an increase in the chain growth probability (α) and in a significant increase in the selectivity to C5+ hydrocarbons, including olefins. Carbon dioxide hydrogenation was studied in a wide pressure range. Only CO is formed as a result of CO2 hydrogenation at a pressure of 0.1 MPa and temperatures from 300 to 400 S. An increase in pressure up to 2.0 MPa leads to a deeper hydrogenation of SO2 to saturated and unsaturated hydrocarbons with α = 0.54—0.66. A further pressure increase up to 6.5—8.5 MPa makes it possible to enhance the selectivity to hydrocarbons. A higher value of the chain growth probability (α = 0.78) was obtained over the FeK/C catalyst in the Fischer—Tropsch synthesis.
TL;DR: The nucleophilic ring-opening reaction of tetrahydropyran derivative of the closo-dode-caborate dianion with sodium azide in the presence of tetrabutylammonium bromide led to the novel azido-derivatives of[B12H12]2−.
Abstract: The nucleophilic ring-opening reaction of tetrahydropyran derivative of the closo-dode-caborate dianion with sodium azide in the presence of tetrabutylammonium bromide led to the novel azido-derivatives of[B12H12]2−. A Cu-catalyzed 1,3-dipolar [3+2] cycloaddition reaction of the closo-dodecaborate dianion azido-derivatives with alkynyl-cholesterol led to 1,4-disubstituted 1,2,3-triazoles with the closo-dodecaborate fragment at position 1. The resulting conjugates are potentially suitable for the development of liposomal drugs to selectively deliver boron into a tumor cell for boron neutron capture therapy of cancer.
TL;DR: In this paper, a novel synthesis of 2,2-bis(2-methoxy-1-oxidodiazenyl)ethyl derivatives of methylnitramine and ethylenedinitramine is presented.
Abstract: A novel synthesis of 2,2-bis(2-methoxy-1-oxidodiazenyl)ethyl derivatives of methylnitramine and ethylenedinitramine consists in the treatment of 2,2-bis(2-methoxy-1-oxidodiazenyl) ethyl trifluoroacetate with the corresponding nitramines and N-ethyl-N, N-diisopropylamine.
TL;DR: In this article, the reaction of [Re6Se8(CN)6]4− cluster anions with Ln3+ cations in the presence of thiophene-2,5-dicarboxylate anions in an aqueous solution was studied.
Abstract: The reaction of [Re6Se8(CN)6]4− cluster anions with Ln3+ cations in the presence of thiophene-2,5-dicarboxylate anions in an aqueous solution was studied. Two new framework compounds were synthesized and structurally characterized: [{Yb(H2O)3}2(tdc)-Re6Se8(CN)6]•10H2O (1) and CsK0,5[{Yb4(OH)4(H2O)7,5(NO3)0,5(tdc)2}{Re6Se8(CN)6}]NO3 • 16.5H2O (2) (tdc is the thiophene-2,5-dicarboxylate anion). Compound 1 crystallizes in a wide pH range (3.0–6.5) and has a porous structure with large open voids accessible to guest molecules. Compound 2 crystallizes at pH 6.0–6.5, contains polynuclear cationic complexes [Yb4(OH)4]8+, and also has a framework structure.
TL;DR: The structure of the trinuclear {Ln2Cd} metal core is stable and independent of the type of peripheral ligands coordinated to cadmium atoms as discussed by the authors.
Abstract: The reaction of Cd(NO3)2 · 4H2O and Eu(NO3)3 · 6H2O or Tb(NO3)3 · 6H2O with potassium 3,5-di-tert-butylbenzoate (Kbzo) and N-donor ligands (1,10-phenanthroline (phen), 2,4-lutidine (2,4-lut), 3,4-lutidine (3,4-lut), phenanthridine (phtd), 2,3-cyclododecenopyridine (cdpy), acridine (acr)) afforded heterometallic LnCd2 complexes: [EuCd2(bzo)7(EtOH)2(phen)] (2), [LnCd2(bzo)7(2,4-lut)4] (Ln = Eu (3), Tb (4)), [EuCd2(bzo)7(H2O)2(2,4-lut)2] · MeCN (5), [EuCd2(NO3)(bzo)6(EtOH)2(2,4-lut)2] (6), [EuCd2(bzo)7(H2O)(EtOH)(3,4-lut)2] · 5EtOH (7), 3[EuCd2(bzo)7(H2O)2(phtd)2] · 4phtd (8), [EuCd2(bzo)7(EtOH)3(cdpy)] (9), 2[EuCd2-(bzo)2(EtOH)4] · acr (10). The structures of complexes 2, 3, and 5–10 were determined by single-crystal X-ray diffraction. The isostructurality of complexes 3 and 4 was confirmed by powder X-ray diffraction. The structure of the trinuclear {Ln2Cd} metal core is stable and independent of the type of peripheral ligands coordinated to cadmium atoms. Photoluminescent properties of compounds 3 and 4 were studied.
TL;DR: In this article, the effect of carbon nanotubes (CNTs) on the morphology and properties of alginate hydrogel was studied and it was found that the CNTs do not affect the efficiency of inclusion and the release rate of the anionic and neutral dyes.
Abstract: The effect of carbon nanotubes (CNTs) on the morphology and properties of alginate hydrogel was studied. The addition of CNTs leads to a change in the structural characteristics of the hydrogel, which is expressed in a decrease in the pore size and gaining a more uniformity by the internal structure. To study the encapsulating properties of the designed compositions, a set of dyes was used that are traditionally applied for testing the drug release rate. It was found that the CNTs do not affect the efficiency of inclusion and the release rate of the anionic and neutral dyes. The change in the kinetics of cationic dye release is caused by the reinforcing effect of the CNTs on the alginate hydrogel and a change in its morphological characteristics.
TL;DR: In this paper, a polymer nanocomposites containing silver nanoparticles, stabilized by hydrophilic copolymers of 1-vinyl-1,2,4-triazole with vinylsulfonic acid sodium salt of different composition, were synthesized.
Abstract: New polymer nanocomposites containing silver nanoparticles, stabilized by hydrophilic copolymers of 1-vinyl-1,2,4-triazole with vinylsulfonic acid sodium salt of different composition, were synthesized. Nanocomposites formation was carried out by the method of chemical reduction of silver ions by sodium borohydride in an aqueous medium in the presence of co-polymer. It was established according to the results of transmission electron microscopy that obtained polymer nanocomposites consist of isolated silver nanoparticles of predominantly spherical shape with a diameter from 2 to 16 nm. It was found that composition of the stabilizing polymer matrix controls such nanocomposites parameters as the polydispersity index of nanoparticles (Dw/Dn = 1.44−1.34), hydrodynamic radii of macrocoils (266−1118 nm), and zeta potential (from −35.0 to −74.8 mV).
TL;DR: In this article, the authors considered the tandem reactions of hydrogenation and hydroaminomethylation without the use of syngas and described reaction systems in which other gases or liquid-dissolved reagents were used as a formyl group source.
Abstract: Hydroformylation reactions and related tandem reactions (hydroformylation—hydrogenation, hydroaminomethylation) proceeding without introduction of syngas were considered. Reaction systems, in which other gases or liquid-dissolved reagents were used as a formyl group source, were described and systematized.
TL;DR: Ru-containing catalysts supported on halloysite aluminosilicate nanotubes (HNTs) were prepared by incipient wetness impregnation, vacuum impregnion, and impregncion under the microwave irradiation methods.
Abstract: Ru-containing catalysts supported on halloysite aluminosilicate nanotubes (HNTs) were prepared by incipient wetness impregnation, vacuum impregnation, and impregnation under the microwave irradiation methods. Composition and structure of the catalysts were determined by X-ray fluorescence (XRF), thermo-programmed reduction (TPR-H2), and transmission electron microscopy (TEM). Textural characteristics were detected by low-temperature nitrogen adsorption—desorption. The activity of the catalysts was investigated in benzene hydrogenation at 80°?, a hydrogen pressure of 3.0 MPa, and a molar ratio of benzene to Ru of 2000. It was found that Ru nanoparticles prepared by vacuum impregnation are deposited mainly into the internal cavity of aluminosilicate nanotubes, while in samples obtained by wetness impregnation the active phase is formed predominantly on the external surface of halloysite. The catalyst prepared by impregnation under microwave irradiation is characterized by a high Ru content, its uniformly distributed metal particles are located mainly on the external surface of HNT, and it demonstrated the superior activity in hydrogenation of benzene to cyclohexane.
TL;DR: The main trends in the chemistry of 1,2-diphosphacyclopentadienes and their derivatives, such as 1, 2-D-phosphate anions, were systematized, analyzed, and generalized as discussed by the authors.
Abstract: The main trends in the chemistry of 1,2-diphosphacyclopentadienes (1,2-diphospholes) and their derivatives 1,2-diphosphacyclopentadienide anions (1,2-diphospholide anions) were systematized, analyzed, and generalized. Methods for the generation of 1,2-diphospholide anions and their reactions with organic and organoelement electrophiles, as well as with transition metal complexes, were considered. Particular attention was paid to the cycloaddition reactions of 1-alkyl-1,2-diphospholes to obtain polycyclic chiral phosphines. A comparative analysis of the reactivity of 1,2-diphospholes and 1,2-diphospholide anions with respect to other representatives of phosphacyclopentadienes and phosphacyclopentadienide anions was carried out. The potential of application of 1,2-diphosphacyclopentadiene derivatives for the design of materials with magnetic, catalytic, and optical properties was shown.
TL;DR: In this paper, quinazolin-4(3H)-one-based cationic surfactants were prepared and fully characterized by IR and NMR spectroscopic techniques and elemental analysis, and physicochemical properties such as density, critical micelle concentration, surface tension, effectiveness in surface tension reduction, Gibbs free energy of micellization, foam and emulsion stability, and anticorrosion activity were determined.
Abstract: For the first time, quinazolin-4(3H)-one-based cationic surfactants were prepared and fully characterized by IR and NMR spectroscopic techniques and elemental analysis. Some of their physicochemical properties, such as density, critical micelle concentration, surface tension, effectiveness in surface tension reduction, Gibbs free energy of micellization, foam and emulsion stability, and anticorrosion activity were determined. Antibacterial and antifungal activities of the synthesized compounds were investigated. N,N-Dimethyl-N-{2-[(2-methyl-4-oxoquinazolin-3(4H)-yl)amino]-2-oxoethyl}tetradecan-1-aminium chloride (4a) showed the highest antibacterial activity against five human pathogens. Antifungal activity against Candida albicans was shown only by surfactant 4a.
TL;DR: In this paper, a DFT study was carried out to investigate how the nature of metal, the oxidation state of the metal (0 and + 2), as well as the structures of N-heterocyclic carbene (NHC) and other ligands influence the heterolytic dissociation energies of metal-ligand bond in the complexes M-NHC.
Abstract: A DFT study was carried out of how the nature of metal, the oxidation state of the metal (0 and +2), as well as the structures of N-heterocyclic carbene (NHC) and other ligands influence the heterolytic dissociation energies of the metal-ligand bond in the complexes M-NHC (M = Ni, Pd, Pt). It was shown that a change in the oxidation state of the metal can be followed by a considerable change in the M-NHC bond dissociation energy (up to nearly 21 kcal mol−1), which is also strongly influenced by the ligand in the trans-position to NHC.
TL;DR: In this article, the supramolecular organization of phthalocyanines (Pc) bearing complex-forming substituents (15-crown-5, 2-oxyphenylphosphonic acid residues) in organized aqueous microheterogeneous media based on cationic and anionic surfactants, bile salts (BS) including sodium deoxycholate (SDC), as well as polyelectrolytes and polymers including a phosphate buffer (pH 7.4).
Abstract: The review is concerned with studies on peculiar features of supramolecular organization of phthalocyanines (Pc) bearing complex-forming substituents (15-crown-5, 2-oxyphenylphosphonic acid residues) in organized aqueous microheterogeneous media based on cationic and anionic surfactants, bile salts (BS) including sodium deoxycholate (SDC), as well as polyelectrolytes and amphiphilic polymers including a phosphate buffer (pH 7.4). Organized, SDC-based fluorescence-active phthalocyanine-containing hydrogels obtained for the first time are also considered. In vitro accumulation and localization of Pc in human cervical adenocarcinoma cells, HeLa, as well as the photochemical and sensitizing properties of Pc including light cytotoxicity and photoinduced generation of reactive oxygen species were demonstrated taking octa-crown-substituted magnesium phthalocyaninate as an example.
TL;DR: New bispyridinium dichlorides based on 2,2-bis(hydroxymethyl)propane-1,3-diyl spacer were synthesized from pentaerythritol, 4-aminopyridine, and carboxylic acids and possess a high antibacterial effect.
Abstract: New bispyridinium dichlorides based on 2,2-bis(hydroxymethyl)propane-1,3-diyl spacer were synthesized from pentaerythritol, 4-aminopyridine, and carboxylic acids. The resulting biocides possess a high antibacterial effect. The minimal inhibitory concentration (MIC) of these compounds against pathogenic bacteria, namely, gram-positive Methicillin-resistant Staphylococcus aureus (strain ATCC 25923) and gram-negative Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853), was established. The influence of the alkyl substituent length in salts on their microbiological activity was studied.
TL;DR: In this article, a new extraction system based on polyethylene glycol 1500 and NaNO3 was proposed for the recovery of light rare-earth elements (Ce, La, Nd, Pr, and Sm) from aqueous solutions.
Abstract: A new extraction system based on polyethylene glycol 1500 and NaNO3 was proposed for the recovery of light rare-earth elements (Ce, La, Nd, Pr, and Sm) from aqueous solutions. The equilibrium distribution coefficients and degrees of extraction of CeIII, LaIII, NdIII, PrIII, and SmIII in the proposed aqueous two-phase system were found. The dependences of the quantitative characteristics of rare-earth element extraction on the temperature, initial metal concentration, and acidity of the medium were obtained. The degree of extraction of the metal ions within one step was shown to exceed 60% at the phase ratio 1:1 without introducing additional complexation agents.
TL;DR: Hybrid compounds based on 4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones containing a piperazine fragment were synthesized as discussed by the authors.
Abstract: Hybrid compounds based on 4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones containing a piperazine fragment were synthesized. Their inhibitory activity against protein kinases NPM1-ALK, ALK, EGFR[L858R][T790], EGFR[L858R], JAK2, and JAK3 was investigated. Compounds with inhibitory activity against protein kinase JAK3 at a level of 16.7 µmol L−1 were obtained.
TL;DR: In this article, the authors used inductively coupled plasma atomic emission spectroscopy (ICP AES) for analytical support of boron neutron capture therapy of cancerous tumors.
Abstract: The determination of boron in animal organ tissues using inductively coupled plasma atomic emission spectroscopy (ICP AES) has been optimized for analytical support of boron neutron capture therapy of cancerous tumors. The proposed technique is universal and rapid. The methodology includes: preliminary acid decomposition at elevated temperatures and pressure (if necessary), determination of boron by ICP AES in the obtained solutions using reference samples based on single-element solutions. The method is verified by spike experiment and varying the weight-samples. The ICP AES technique was used to evaluate the accumulation of boronophenylalanine and borocaptate in mice organs. Biodistribution of 10B in the case of intravenous administration of the drug to SCID mice with SPF status using the human glioblastoma cell line U87 was investigated.
TL;DR: Gold complexes [Ph3PR]-[Au(CN)2I2-trans]− were synthesized by the reaction of potassium dicyanodiiodoaurate with tetraorganylphosphonium chlorides in acetonitrile and were structurally characterized.
Abstract: Gold complexes [Ph3PR]+[Au(CN)2I2-trans]−, where R = Et (1), CH2Ph (2), Ph (3), were synthesized by the reaction of potassium dicyanodiiodoaurate with tetraorganylphosphonium chlorides in acetonitrile and were structurally characterized. The phosphorus atoms in the cations are in a tetrahedral environment. In the centrosymmetric square [Au(CN)2I2]− anions of complexes 1–3, the Au—I distances have similar values (2.617(2), 2.623(2), and 2.611(2) A, respectively); the largest bond length is observed in complex 2. The Au-C and C≡N bond lengths in complexes 1–3 are 1.993(5), 2.002(4), 2.003(19) A and 1.130(6), 1.074(7), 1.12(2) A, respectively. In the tetrahedral [Ph3PR]+ cations (C-P-C angles, 105.5(10)–111.2(7)°), the P-C distances vary in the range of 1.797(4)–1.816(4) A. The structural organization of the crystals of compounds 1–3 is due mainly to weak N⋯H-C hydrogen bonds (2.44–2.74 A) between hydrogen atoms of the cations and nitrogen atoms of the anions.