Scandinavian Journal of Clinical & Laboratory Investigation 

About: Scandinavian Journal of Clinical & Laboratory Investigation is an academic journal published by Taylor & Francis. The journal publishes majorly in the area(s): Renal function & Blood pressure. It has an ISSN identifier of 0036-5513. Over the lifetime, 8814 publications have been published receiving 221364 citations. The journal is also known as: Clinical and laboratory investigation & Scandinavian journal of clinical and laboratory investigation.

The glomerular permeability determined by dextran clearance using Sephadex gel filtration.

Abstract: A method is described for measuring glomerular permeability by dextran clearance using Sephadex gel filtration technique. Clearance is shown to be a function of molecular size, decreasing with increasing molecular weight. At a mol. weight higher than 55,000, the clearance is very low and approximately zero, while it averages 95 ml per minute at a mol. weight of 15,000. If plotted in a log.log. graph, a linear relation is found between clearance and molecular weight. In a semilog. graph, however, with clearance plotted against log. Stokes radius, the relation is also linear, with a slight deflection in the high molecular part, however.