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JournalISSN: 0036-5548

Scandinavian Journal of Infectious Diseases 

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About: Scandinavian Journal of Infectious Diseases is an academic journal. The journal publishes majorly in the area(s): Population & Meningitis. It has an ISSN identifier of 0036-5548. Over the lifetime, 6581 publications have been published receiving 138464 citations.


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Journal ArticleDOI
TL;DR: 65 episodes of rotavirus diarrhoea, detected during a longitudinal follow-up of 336 infants from birth to 24-32 months of age, were analyzed for clinical symptoms and a 0-20 point numerical score was devised according to the distribution of clinical features in the patients.
Abstract: 65 episodes of rotavirus diarrhoea, detected during a longitudinal follow-up of 336 infants from birth to 24–32 months of age, were analyzed for clinical symptoms. Rotavirus gastroenteritis was characterized by watery diarrhoea, vomiting (particularly in older children), fever and dehydration. A 0–20 point numerical score was devised according to the distribution of clinical features in the patients. Using this system, the mean severity score for the 65 episodes of rotavirus diarrhoea was 11.0 ± 3.7 as compared to 5.6 ± 3.2 for the 183 episodes of non-rotavirus diarrhoea in the same population (p<0.0001, t-test). The 20 point score is proposed for analysis of efficacy studies of candidate rotavirus vaccines.

672 citations

Journal Article
TL;DR: A newly developed Herpes simplex virus type 1 and type 2 enzyme immunoassay has been applied to over 40,000 sera from different populations in the US and 17 other countries on all 5 continents, providing an objective measure of various aspects of sexual behavior.
Abstract: A newly developed Herpes simplex virus (HSV) type 1 and type 2 enzyme immunoassay has been applied to over 40,000 sera from different populations in the US and 17 other countries on all 5 continents The HSV-1 antibody patterns found permit the current and past socioeconomic status, as well as the extent of oral-genital sexual contact, to be deduced for various populations The HSV-2 antibody results provide an objective measure of various aspects of sexual behavior: extent of polypartnerism in the subjects tested (or their contacts), early age of sexual experience and acquisition rates of genital herpes It has thus been possible to extend sero-epidemiology to sero-sociology which can provide objective markers for sexual behavior and effects of intervention or educational approaches Besides such markers having potential applicability for monitoring other STDs, such as HIV infection, recent studies also support a possible role for HSV infections to increase the transmissibility, not only of HIV-1, but also of HTLV-1

540 citations

Journal ArticleDOI
Manuela Caniça1, F. Nato1, L. Du Merle1, J. C. Mazie1, G. Baranton1, D. Postic1 
TL;DR: This study documents the involvement of B. afzelii sp.
Abstract: Borrelia isolates associated with Lyme borreliosis were previously divided into 3 genospecies, B. burgdorferi sensu stricto, B. garinii and group VS461, on the basis of DNA homology. B. burgdorferi sensu stricto and B. garinii were identified by monoclonal antibodies (MAbs), H3TS and D6 respectively, but no MAbs were available to identify group VS461. Two MAbs were produced, I 17.3 and J 8.3 which reacted with OspB and OspA proteins, respectively, of strains belonging to group VS461, which should be named B. afzelii sp. nov. 24 strains were assigned to B. afzelii sp. nov., 11 of them being isolated from skin lesions, 6 from acrodermatitis chronica atrophicans (ACA) and 5 from erythema chronicum migrans (ECM). Although quite unknown in the USA, ACA has frequently been reported in northern Europe where B. afzelii sp. nov. is commonly isolated. This study documents the involvement of B. afzelii sp. nov. as a specific aetiological agent of ACA.

422 citations

Journal ArticleDOI
TL;DR: General aspects of Toxoplasmosis are reviewed and diagnostic methods currently used in medical laboratories for the diagnosis are focused on, i.e. PCR and serologic assays plays the main role in the diagnosis of congenital infection and assists in the confirmatory diagnosis of toxoplasmic encephalitis and ocular toxoplasmaosis.
Abstract: Toxoplasmosis is a worldwide infection caused by the intracellular parasite Toxoplasma gondii. At least a third of the world human population are infected with the parasite, making it one of the most successful parasitic infections. Primary maternal infection may cause health-threatening sequelae for the foetus, or even cause death in uterus. Reactivation of a latent infection in immune deficiency conditions such as AIDS and organ transplantation can cause fatal toxoplasmic encephalitis. Toxoplasmosis is a major cause of retinochoroiditis, especially in individuals with an impaired immune system. Despite the usually 'asymptomatic' nature of the infection, a significant burden imposed by the parasite necessitates the implementation of effective means for the prevention, diagnosis, and management of this disease. Laboratory diagnosis, i.e. PCR and serologic assays, plays the main role in the diagnosis of congenital infection and assists in the confirmatory diagnosis of toxoplasmic encephalitis and ocular toxoplasmosis. Here, we briefly review general aspects of Toxoplasma infection and focus on the diagnostic methods currently used in medical laboratories for the diagnosis of Toxoplasma infection.

293 citations

Journal ArticleDOI
TL;DR: In this article, the link, interplay and network of cytokines taking place during sepsis are illustrated by the correlations between the levels of most pro- and anti-inflammatory cytokines.
Abstract: Sepsis is associated with an exacerbated production of both pro- and anti-inflammatory cytokines, which are detectable within the bloodstream. Their 'half-angel, half-devil' properties are fully illustrated in sepsis. While they are a prerequisite to fight infection, their overzealous production is deleterious. The highest levels are found in plasma of non-surviving patients: they are markers and causative agents of poor outcome. Only the level of the chemokine RANTES is inversely associated with the APACHE II score (r = -0.7; p = 0.02) and low levels are associated with poor outcome. The link, interplay and network of cytokines taking place during sepsis are illustrated by the correlations between the levels of most pro- and anti-inflammatory cytokines. Excessive release of anti-inflammatory cytokines may be associated with the immunodysregulation observed in sepsis. However, despite the presence of huge amounts of anti-inflammatory cytokines and molecules targeting specifically interleukin-1 (IL-1) (i.e. IL-1 receptor antagonist) and tumour necrosis factor (TNF) (i.e. soluble TNF receptors), there is no indication that their levels are sufficient to counteract fully these proinflammatory cytokines. TNF was initially thought to be the 'hub of the cytokine network'. Although TNF contributes towards favouring the production of many other cytokines within a complex cascade, there are numerous examples to illustrate that its presence is not a prerequisite for these productions.

285 citations

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Performance
Metrics
No. of papers from the Journal in previous years
YearPapers
20171
2014154
2013159
2012169
2011167
2010166