Showing papers in "Schizophrenia Research in 2017"

TL;DR: The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission.

TL;DR: Among patients with schizophrenia, LAI use is associated with an approximately 30% lower risk of death compared with oral agents, and SG LAIs and oral aripiprazole are associated with the lowest mortality.

TL;DR: Resting-state fMRI investigations of thalamic pathology in schizophrenia are summarized, with particular attention paid to the course, diagnostic specificity, and clinical correlates of thalamocortical network dysfunction.

TL;DR: A systematic review of studies investigating the association between peripheral levels of cytokines and C-reactive protein (CRP), cytokine gene polymorphisms and cognition in patients with schizophrenia and bipolar disorder suggests peripheral inflammation might be related to cognitive deficits in schizophrenia and BD.

TL;DR: This review takes stock of recent research into treatment of negative symptoms by summarizing psychosocial as well as pharmacological and other biological treatment strategies, and addresses methodological issues, in particular the heterogeneity of negative Symptoms and treatment response.

TL;DR: The relevance of recent developments in psychopathological assessment of negative symptoms, such as the distinction between amotivation and diminished expression, are emphasized, which have only rarely been applied in research on secondary negative symptoms.

TL;DR: Antipsychotic-naïve patients with FENP present subclinical dyslipidaemia, and effect size estimates as Hedges' g and pooled data using random- or fixed-effects models depending on heterogeneity reflect disease-specific mechanisms.

TL;DR: Overall, SZ-PRS was associated with increased risk for psychiatric disorders such as depression and bipolar disorder, lower performance IQ and negative symptoms, and a framework is proposed to guide robust reporting of PRS associations in the future.

TL;DR: Overall, findings indicate that third wave interventions show beneficial effects on symptoms in persons with psychotic disorders, however, further research is required to determine the efficacy of specific models of treatment.

TL;DR: It is feasible that exposure to xenobiotic heavy metals, constituents of air pollution such as particulate matter and nitrogen and sulfur oxides, organic solvents, and other constituents of environmental pollution could be component causes of schizophrenia.

TL;DR: Several potential metabolite signatures of schizophrenia including reduced levels of essential polyunsaturated fatty acids, vitamin E and creatinine, and elevated levels of lipid peroxidation metabolites and glutamate are revealed.

TL;DR: The link between atypical multisensory temporal perception and clinical symptomatology suggests that clinical symptoms of schizophrenia may be at least partly a result of cascading effects from (multi)sensory disturbances.

TL;DR: The findings suggest that Relating Therapy might be effective for reducing AH distress, and a larger, suitably powered phase 3 study is needed to provide a precise estimate of the effects ofrelating Therapy for AH distress.

TL;DR: The frequency and distribution of psychiatric diagnoses at baseline and over time in the North American Prodrome Longitudinal Study (NAPLS 2) and the role of comorbid diagnoses in conversion to psychosis are determined.

TL;DR: The evolution of concepts and assessment modalities relevant to PPNS, data on prevalence of DS and PNS, as well as studies on clinical, neuropsychological, brain imaging electrophysiological and psychosocial functioning aspects of DSand PNS are reviewed.

TL;DR: It is proposed that SZ and ASD lay at opposite extremes of a particular component of the representation of self; namely, self-location and the construct of peripersonal space, and multisensory training focused on either sharpening or making shallower the self-other boundary may hold promise as an interventional tool in the treatment of these disorders.

TL;DR: Electroencephalographic studies demonstrating sleep spindle deficits in patients with schizophrenia are reviewed, and data indicating that spindle impairments point to a TRN-MD thalamus-prefrontal cortex circuit deficit are presented, and the possible molecular mechanisms underlying thalamo-corticalSleep spindle abnormalities in schizophrenia are discussed.

TL;DR: The MSS is based on current conceptual models and taps positive, negative, and disorganized dimensions of schizotypy and appears to provide a promising measure for assessing schizotypesy.

TL;DR: Monitoring of clozapine levels is essential during hospitalisation for infection and consideration should be given to gradual dose reduction to minimise dose related side effects.

TL;DR: As a group, people with NAP have a slight increase in FG, which most of them maintain in the normal range despite a small increase in IR by secreting additional INS, and when faced with a physiological challenge, they are no longer able to maintain a normal glucose concentration.

TL;DR: The findings of this systematic review support the frontotemporal hypothesis of schizophrenia, and the disruption in prefrontal and STG might represent the pathophysiology of schizophrenia disorder at a relatively early stage.

TL;DR: It is proposed that negative symptoms may become more tractable when the different domains and individual symptoms are taken into account, and a better understanding of these areas may facilitate specific treatment approaches.

TL;DR: This review provides an overview of existing negative symptom scales, focusing on both observer-rated and self-rated measurement of negative symptoms, and critically discusses strengths and limitations of these measures in the light of some existing challenges.

TL;DR: This systematic review confirms the existence of cytokines abnormalities in schizophrenia disease and provides a strong evidence of a concomitant process of inflammatory activity in schizophrenia illness course.

TL;DR: A subgroup of patients who obtained remission of psychotic symptoms while not being on antipsychotic medication at the 10-year follow-up was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse.

TL;DR: A dimensional latent structure of paranoia implies that the processes involved in sub-clinical paranoia may be similar to those in clinical paranoia.

TL;DR: A comprehensive, team-based FEP treatment approach was associated with greater improvement in work or school participation, and this effect appears to be mediated, in part, by participation in SEE.

TL;DR: There is a component of common genetic variation that is shared between smoking behaviors and schizophrenia, and genetic correlation was observed between schizophrenia and three of the five smoking phenotypes.

TL;DR: It is argued that complex I, being a major factor in the regulation of mitochondrial ETC, is a possible key modulator of various functions of the mitochondria, with a focus on the first complex of the mitochondrial electron transport chain (ETC).

TL;DR: The current findings of stereological studies of the thalamus in schizophrenia support the idea that thalamo-cortical dysfunction in schizophrenia might be attributable, at least in part, to structural alterations in the pulvinar that could impair thalamic inputs to higher order cortical association areas in the frontal and parietal lobes.