Showing papers in "Seminars in Arthritis and Rheumatism in 2015"
••
TL;DR: The therapeutic use of colchicine has extended beyond gouty arthritis and familial Mediterranean fever, to osteoarthritis, pericarditis, and atherosclerosis, and further understanding of the mechanisms of action underlying the therapeutic efficacy will lead to its potential use in a variety of conditions.
548 citations
••
TL;DR: A systematic review of structural and functional brain abnormalities in chronic low back pain (CLBP) using several brain magnetic resonance imaging (MRI) techniques is presented in this paper, where the authors evaluated structural gray matter changes.
194 citations
••
TL;DR: The study concludes that the social cost of osteoarthritis could be between 0.25% and 0.50% of a country's GDP, which should be considered in order to foster studies that take into account both healthcare and non-healthcare costs.
178 citations
••
TL;DR: A group of 8 experts in this field, from European countries, met to debate on 24 statements, and a consensus position has been proposed for each statement.
132 citations
••
TL;DR: Anti-CD20 B cell depletion therapy is effective on skin involvement but seems also to preserve the pulmonary function, as supported by a stable or improved FVC and stable interstitial score, suggesting a possible role of rituximab as a modifying therapy overall in early diffuse SSc.
129 citations
••
TL;DR: Overall results suggest that, although peripheral mechanisms are involved, hypersensitivity of the central nervous system plays a role in a subgroup within the shoulder pain population.
122 citations
••
TL;DR: TCZ therapy leads to rapid and maintained improvement in patients with refractory GCA and/or with unacceptable side effects related to corticosteroids, however, the risk of infection should be kept in mind when using this drug in Patients with GCA.
119 citations
••
TL;DR: Although patients with non-radiographic axSpA have shorter disease duration and lack radiological changes, they demonstrate a substantial burden of illness, with self-reported disease activity and functional impairments comparable to those found in patients with radiographic disease.
106 citations
••
TL;DR: Despite recent advances in the management of CIRD, incidence of CVD remains increased in Spanish subjects with CIRD attending outpatient rheumatology clinics.
101 citations
••
TL;DR: MAS may be a frequently under-recognized complication of KD, because the understanding of complications and diagnostic criteria are still in progress and the HLH 2009 criteria have low sensitivity and specificity.
98 citations
••
TL;DR: AS patients appear to have a higher risk of myocardial infarction and stroke, and management of cardiovascular risk factors and control of systemic inflammation should be taken into account in AS to decrease this high cardiovascular risk.
••
TL;DR: More than 60 years after its initial description, SRC still remains an important cause of morbidity and mortality in scleroderma and the prognosis of SRC has improved substantially.
••
TL;DR: Harmonization of the recommendations for knee OA treatment is challenging but feasible, as shown by the step-by-step therapeutic algorithm developed by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).
••
TL;DR: Women suffering from fibromyalgia have thinner corneal stromal nerves and diminished sub-basal plexus nerve density when compared to healthy controls andCorneal confocal microscopy could become a useful test in the study of patients with Fibromyalgia.
••
TL;DR: The strength of the evidence is not sufficiently robust to draw specific recommendations on how to balance between the need to treat the patient with SLE with immunosuppressive drugs and the risk of severe infections.
••
TL;DR: A significant association was found between disc space narrowing in both community- and occupational-based populations without significant differences between the associations, which supports that spondylolisthesis may contribute a specific cause for LBP.
••
TL;DR: It is important to recognize RISS clinically, as it may mimic exacerbation of various rheumatologic conditions, and further infusions of rituximab should be avoided, asIt may provoke more severe symptoms.
••
TL;DR: This large multicenter study of allopurinol dose-titration strategy was well tolerated, without new safety signals emerging over 6 months, but despite encouragement to treat to target, significant proportions of patients did not achieve target sUA.
••
TL;DR: Clinical trials aim to resolve uncertainties that may remain following nonclinical development regarding the similarity of the proposed biosimilar with the reference product and serve to inform phase 3 clinical development.
••
TL;DR: The results reinforce the understanding of fibromyalgia as a polysymptomatic distress condition with pain as its main symptom and support that Fibromyalgia seems to have a greater impact on physical than on psychological outcomes, though both are largely affected.
••
TL;DR: It is worked out that bone waste is an adaptive, evolutionarily positively selected program that is absolutely necessary during acute inflammation, but when acute inflammation enters a chronic state due to the inability to terminate inflammation, the acute program of bone loss is a misguided adaptive program.
••
TL;DR: The finding of an activated IL-6 pathway in patients with AAV, together with the observed effects of tocilizumab monotherapy, provides evidence for a possible central role of IL- 6 in the pathogenesis of AAV and suggests its targeting as a potential treatment.
••
TL;DR: The available data suggest that gout patients incur substantially greater direct and indirect costs as compared with gout-free individuals among elderly and treatment-refractory gouty patients, whereas the costs are considerably less among younger, employed goutY patients.
••
TL;DR: An overview of arthroplasty in RA is provided, the evidence supporting perioperative medication management including corticosteroids is summarized, and areas where further study is needed are identified.
••
TL;DR: The data suggest that TCZ may be considered for patients with refractory NBD, and the prednisone dose could successfully be tapered to about 20mg/day, while in another patient glucocorticoids could safely be withdrawn.
••
TL;DR: There is a need for a standard "appropriate methodology" that is agreed upon for osteoarthritis clinical practice guidelines in order to prevent the development of conflicting recommendations for intra-articular hyaluronic acid treatment for knee osteOarthritis.
••
TL;DR: Anti-TNF-α therapy is effective in sarcoid uveitis patients refractory to conventional immunosuppressive therapy and a substantial reduction in prednisone dose despite having failed standard therapy is observed.
••
TL;DR: The most common reason why individuals with SLE did not receive pneumococcal and influenza vaccines was that physicians failed to recommend them, and data suggest that increasing vaccination rates in SLE will require improved process quality at the provider level, as well as addressing patient concerns and barriers.
••
TL;DR: BCS associated with BS is usually due to IVC thrombosis with or without hepatic vein throm BCS, and Silent cases exist and have a better prognosis.
••
TL;DR: These findings provide population-based evidence that patients with SLE have a substantially increased risk of VTE, especially in the first year after SLE diagnosis.