Showing papers in "Seminars in Cancer Biology in 2021"

TL;DR: The integration of phytotherapy and nanotechnology in the clinical setting may improve pharmacological response and better clinical outcome of patients.

TL;DR: Details of the nano-based therapeutics and diagnostics strategies, and the potential use of nanomedicines in cancer drug delivery and cancer therapy are discussed.

TL;DR: The upcoming category of HER2-low breast cancer is defined with respect to emerging clinical data on the efficacy of specific anti-HER2 agents in subgroups of breast carcinomas lacking the classical oncogene addition dictated by HER2 amplification.

TL;DR: The dominating evidence extracted from the literature points towards a high potential of radiomics in disentangling malignant from benign breast lesions, classifying BC types and grades and also in predicting treatment response and recurrence risk.

TL;DR: The impact of flavonoids nano-formulations on the improvement of their bioavailability, therapeutic and safety profile and will open new insights in the field of drug discovery for cancer therapeutics are focused on.

TL;DR: This review comprehensively highlights the potentiality of various nanocarriers and nanomedicines for multifaceted applications in diagnostics and drug delivery, especially the potentialities of polymeric nanoparticle, nanoemulsion, solid-lipid nanoparticles, nanostructured lipid carrier, self-micellizing anticancer lipids, dendrimer, nanocapsule and nanosponge-based therapeutic approaches in the field of cancer.

TL;DR: The utility of lncRNAs as biomarkers of cancer progression, and their potential use as therapeutic targets for treatment of cancer are discussed.

TL;DR: Recent concepts and therapeutic opportunities for the utilization of antidiabetics, antibiotics, antifungal, anti-inflammatory, antipsychotic, PDE inhibitors and estrogen receptor antagonist, Antabuse, antiparasitic and cardiovascular agents/drugs as an alternative approach against human malignancies are focused on.

TL;DR: Focus on new therapeutic frontier represented by immunotherapy is illustrated, with particular mention of immune checkpoint inhibitors introduction in TNBC therapy and their impact on future treatments.

TL;DR: The aim of this review is to provide an overview of the basic concepts and developments in the field AI for breast cancer detection in digital mammography and digital breast tomosynthesis.

TL;DR: A comprehensive overview of the current scenario of drug repurposing for the breast cancer treatment is described and it is suggested that serendipity plays a major role in the drug development.

TL;DR: Computer in-silico strategies have been developed to aid in modeling biological processes to find new disease-relevant targets and discovering novel drug-target and drug-phenotype associations as they pertain to cancer biology and immunomodulation.

TL;DR: The mechanism of nanoparticles targeted drug delivery, recent advancement of therapeutic strategies of nanoparticle based carriers for small interfering RNA, microRNA, and gene augmentation therapies in BC, and the future prospect and challenges of nanop articles based therapies for BC are discussed.

TL;DR: Fat-mediated alterations of the gut microbiota link bile acid metabolism to CRC risk and colonic tumorigenesis, exemplifying how gut microbial co-metabolism affects colon health.

TL;DR: This review highlights the mechanisms and therapeutics of ginger and its bioactive compounds focused on a cancer context and these evidence are based on the cytotoxic effect against cancer cell lines, enzyme inhibitory action, combination therapy with chemotherapeutic and phenolic compounds, possible links to the microbiome and the use of nano-formulations of gingerBioactive compounds as a more effective drug delivery strategy in cancer therapy.

TL;DR: The role of p53-mediated metabolic regulation in tumor suppression is complexed by its function to promote both cell survival and cell death under different physiological settings as mentioned in this paper, and p53 can regulate both prooxidant and antioxidant target genes for complete opposite effects.

TL;DR: A synopsis of current progress in theranostic applications for lung cancer diagnosis and therapy using NPs including liposome, polymeric NPs, quantum dots, gold NPS, dendrimers, carbon nanotubes and magnetic NPs is provided.

TL;DR: The present review focuses on the molecular modes of chemoprevention, chemoprotection and drug synergism with special emphasis to preclinical and clinical applications, pharmacokinetics, pharmacodynamics and advanced drug delivery methods for the development of next-generation personalized cancer therapeutics.

TL;DR: The "common soil" hypothesis may promote the application of preventive strategies, particularly targeting lifestyles, for a broad spectrum of widely prevalent disorders, ranging from breast cancer to myocardial infarction or to cognitive impairment conditions.

TL;DR: The current progress about the regulatory role of several representative RNA modifications in cancers are reviewed, including N6-methyladenosine (m6A), 5-methylcytosine ( m5C), N1- methyladenoside (m1A) and 2'-O-methylation (Nm).

TL;DR: The role of TILs, TIICs and TLS in breast cancer (BCa); (ii) the different metabolic-based pathways used by immune and breast cancer cells; and (iii) implications for immunotherapy-based strategies in BCa are addressed.

TL;DR: The intent of this literature research is to explore the potential of garlic-derived products and bioactive organosulfur compounds as cancer chemopreventive and chemotherapeutic agents and concerns and limitations that have arisen in past studies regarding standards of measurement, bioavailability, and method of delivery are addressed.

TL;DR: The mechanisms of the regulation of checkpoint inhibitors (PD-1/PD-L1) in breast cancer are discussed, the predictive aspects in the PD-L 1 testing are explored and the most accurate and reliable assessment of immune cells as potential targets are discussed.

TL;DR: Light is shed on various types of nanoparticles used for diagnosis and drug delivery in CRC and how these nanoparticles can improve diagnostic accuracy and promote selective drug targeting to tumor sites with increased efficiency and reduced cytotoxicity against healthy colon tissue.

TL;DR: In conclusion, although human studies are needed, NPs obtained from food-derived flavonoids have promising anticancer effects in vivo and are good candidates as drug delivery for anticancer drugs in green synthesis systems.

TL;DR: In this article, the authors discuss the origin, behavior and biological toxicity of different metal nanoparticles with the aim of rationalizing related health hazards and calling attention to toxicological concerns involved in their increasingly widespread use.

TL;DR: How in-silico drug repurposing has the promise to shortly improve the authors' arsenal of anticancer drugs and, likely, overcome certain limitations of modern cancer therapies against old and new therapeutic targets in oncology is discussed.

TL;DR: Light is shed on the application of EVs in cancer therapy, such as targeted chemotherapy, gene therapy, and vaccine development, through aspects of biogenesis, isolation, targeting, and loading of EVs.

TL;DR: The importance of STAT3-dependent functions in cancer, the status of compounds designed as direct-actingSTAT3 inhibitors, and some of the strategies for repurposing of drugs as STAT3 inhibitors for cancer therapy are discussed.

TL;DR: In this paper, the authors focus on revealing the mechanisms leading to the hyperactivation of PI3K/Akt/mTOR signaling in cancer and summarizing efforts for developing PI3k/akt/ mTOR inhibitors as either mono-therapy or combination therapy in different cancer settings.