Seminars in Immunology 

TL;DR: A major focus of this review is on factors that modulate the interaction of macrophages and foreign body giant cells on synthetic surfaces where the chemical, physical, and morphological characteristics of the synthetic surface are considered to play a role in modulating cellular events.

TL;DR: Toll-like receptors have been established to play an essential role in the activation of innate immunity by recognizing specific patterns of microbial components and TIR domain-containing adaptors provide specificity of TLR signaling.

TL;DR: There is strong biochemical and genetic evidence that the IKK complex, which consists of two catalytic subunits, IKKα and IKKβ, and a regulatory subunit, Ikkγ, is the master regulator of NF-κB-mediated innate immune and inflammatory responses.

TL;DR: This manuscript provides an overview of studies that have evaluated the immune response to biologic scaffold materials and variables that affect this response and investigates the role of cross species antigens in this response.