Shandong Medical Journal
About: Shandong Medical Journal is an academic journal. The journal publishes majorly in the area(s): Genotype & Apoptosis. It has an ISSN identifier of 1002-266X. Over the lifetime, 285 publication(s) have been published receiving 445 citation(s).
TL;DR: Genetic polymorphisms of DNA repair genes are not associated with hepatocarcinogenesis and frequency of wild-type allele of X-ray repair cross complementing group 1(XRCC1) Arg399Gln is higher in case group.
Abstract: Objective To investigate the relationship between genetic polymorphisms of DNA repair genes and hepatocellular carcinomaMethods Genetic polymorphisms of DNA repair genes had been identified in 150 pateients with hepatocellular carcinoma(case group) and 150 healthy individuals(control group) by PCR-RFLPResults Compared with control group,frequency of wild-type allele of X-ray repair cross complementing group 1(XRCC1) Arg399Gln is higher in case groupNo significant difference of urinary 8-hydroxy-2-deoxyguanosine(8-OHdG) levels among different polymorphism genotypes in XRCC1 Arg194Tr,Arg280His,Arg399Gln and human 8-oxoguanine DNA glycosylase 1(hOGG1) Ser326CysConclusion Genetic polymorphisms of DNA repair genes are not associated with hepatocarcinogenesis
TL;DR: The novel endometrial adenocarcinoma cell line is successfully established and the expression of cytokeratin was positive in the cells.
Abstract: Objective To establish human endometrial adenocarcinoma cell line.Methods Tumor tissues from 1 case with well differentiated endometrial adenocarcinoma were made into single-cell suspension and cultured in DMED/F-12 medium supplemented with 10% fetal bovine serum.The morphology of the cells was observed by inverted microscope.The immunofluorescent staining technique was used to detect cytokeratin in endometrial carcinoma cells.Results The cells were subcultured more than 50 generations,monolayer cultured cells were polygonal in shape and had a tendency to pile up without contact inhibition.The expression of cytokeratin was positive in the cells.Conclusion The novel endometrial adenocarcinoma cell line is successfully established.
TL;DR: Chemotherapy can lead to ovarian function damage in breast cancer patients, while chemotherapy combined with GnRHa was one of the effective means to protect ovarian function.
Abstract: Objective To investigate the effect of GnRHa in preventing chemotherapy-induced ovarian failurMethods 21 cases of postoperative adjuvant systemic chemotherapy in breast cancer were randomly divided into two groups: 11 cases of the control group were treated with conventional chemotherapy;10 cases of the study group were treated with conventional chemotherapy and Diphereline 375 mg im q28d every month subsequently until the end of chemotherapy,regular monitoring of the patient′s sex hormone levels and menstrualResults 8 cases of patients had amenorrhoea at three chemotherapy courses in the control,3 cases restored menstrual after stopping treatment,the time required to restore the menstrual with 30-90 d,an average of about 73 dAll of patients in the study group had amenorrhoea in the first period of chemotherapy,9 cases recovered menstrual flow after chemotherapy,only 1 case had menstrual disorders,the time required to restore the menstrual with 37-46 d,an average of about 40 dThe menstruation recovery rate and recovery time were different in two groups after stopping(P005)The level of FSH,LH and E2 in the control group were higher than those in the study group when the chemotherapy stopped(P005)When the chemotherapy was stopped,the FSH level of those who were not amenorrhoea was higher than those of before treatment(P005),but the level of E2 and LH had no significant differences(P005)Conclusion Chemotherapy can lead to ovarian function damage in breast cancer patients,while chemotherapy combined with GnRHa was one of the effective means to protect ovarian function
Abstract: In this study, a simple and high-resolution four-degrees-of-freedom (4-DOF) motion error measuring system based on DVD pickup has been proposed. it can simultaneously measure the horizontal straightness error and three angular errors of a single-axis linear moving platform. The horizontal straightness error is measured based on the focus technique of DVD pickup and the inverse algorithm is used to solve pitch, yaw, and roll angular errors through the kinematic analysis. The grating is mounted on the moving axis of a single-axis linear moving platform and reflects incident laser beam into several diffractive rays. Photodiode IC (PDIC) of DVD pickup is set up for detecting the focus error signal (FES) of zero-order diffraction ray from grating and quadrant detectors are set up for detecting the position of ±1st-order diffraction rays from grating. The 4-DOF motion error measuring system detected the three angular errors with a related accuracy of about ±1 arc sec for a measuring range of ±100 arc sec, and detected horizontal straightness with a related accuracy of about ±2 μm for a measuring range of ±150 μm.
TL;DR: CYP1A1 Val/Val and GSTM1 null genotypes may be the susceptible factors of lung cancer in Chinese Han nationality of Shandong and there may be a synergetic interaction between smoking and susceptible genotypes.
Abstract: Objective To explore the relationship between CYP1A1,GSTM1 gene polymorphisms and genetic susceptibility to lung cancerMethods In this study,110 lung cancer patients and 125 age-matched healthy controls in Chinese Han nationality of Shandong were enrolledAll DNA samples from peripheral blood were genotyped for genetic polymorphisms of CYP1A1 and GSTM1 genes by oligonucleotidechip techniqueResults The significant differences for distributions of CYP1A1 m2 and GSTM1 genotype were observed between lung cancer cases and healthy controlsThe individuals carried CYP1A1 Val/Val or GSTM1 null genotype had an increased risk for lung cancerThere was an elevated risk for smokers in lung cancer cases having CYP1A1 Val/Val or GSTM1 null genotypeConclusions CYP1A1 Val/Val and GSTM1 null genotypes may be the susceptible factors of lung cancer in Chinese Han nationality of ShandongThere may be a synergetic interaction between smoking and susceptible genotypes
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