Showing papers in "Steroids in 1992"

TL;DR: This review briefly summarizes key researches on the structure of the sterol molecule from its very beginnings to the definitive elucidation in 1932, which covers the period from the 1930s to the 1960s.

TL;DR: Racial and ethnic variations in serum testosterone levels were investigated among a large sample of male Vietnam era veterans and were interpreted as having considerable potential for explaining some of the race differences in the incidences of cardiovascular diseases, hypertension, and prostate cancer.

TL;DR: The confluence of an extraordinary coalescence of multiple events and circumstances in the growth of the Upjohn Company with the Mayo discovery, inclusive of a pioneering role in the steroid field, conspired to create an environment ripe for innovation.

TL;DR: Two of the most important Syntex contributions--the synthesis of 19-nor-17 alpha-ethynyltestosterone (norethindrone) and of cortisone from diosgenin--are described from a historical perspective.

TL;DR: Of the four clones studied, supernatant from one clone (A2), compared with other cortisol monoclonal antibodies, showed minimal cross-reactivity to other C21 steroids and was suitable for the direct determination of cortisol in plasma by enzyme-linked immunosorbent assay using a standard 96-well microtiter plate.

TL;DR: It is demonstrated that plant estrogens, at natural dietary levels, produce significant, agonistic actions in several estrogen-dependent tissues and processes and may have induced some permanent changes in reproductive function.

TL;DR: The studies show that the naturally occurring phytoestrogens have dramatic estrogenic effects at natural dietary levels and may have the same implications for development, health, and disease as do the steroidal estrogens produced by the body.

TL;DR: The 17-epimers of the anabolic steroids bolasterone (I), 4-chlorodehydromethyltestosterone (II), fluoxymesterone (III), furazabol (IV), metandienone (V), mestanolone (VI), methyltestrone (VII), methandriol (VIII), oxandrolone (IX), oxymestersone (X, oxymetholone) (XI), stanozololol (XII), and the human metabolites 7 alpha,17

TL;DR: The era of oral contraception began in May 1960, when Enovid was approved by the Food and Drug Administration for ovulation inhibition, and was immediately thereafter introduced for such use.

TL;DR: It is concluded that the stress of residency training leads to a quantifiable depression of gonadal function, and that gonadal steroid concentrations may be useful in evaluating measures intended to reduce that stress.

TL;DR: A method of gas chromatographic/mass spectral (GC/MS) analysis for the identification of individual CCEs is presented; the major fragmentation ions of authentic estrogen standards as trimethylsilylether derivatives, and the MS patterns of the major C CEs, namely, 2-hydroxyestradiol and hydroxyestrone, are included.

TL;DR: Using gas chromatography/mass spectrometry, a method for the simultaneous determination of six plasma steroids is developed, providing a sensitive and specific technique with good accuracy and precision.

TL;DR: The cortisone era had a profound impact on drug discovery also, since it led to the logical application of steric and electronic concepts to medicinal chemistry and taught medicinal chemists many important lessons about drug-receptor interactions.

TL;DR: Estrogen responsiveness of T1/Pr1 cells was demonstrated by their suppression of growth in phenol red-free and/or tamoxifen-supplemented medium and by the reversal of antiproliferative effect of tamoxIFen by Phenol red and estradiol.

TL;DR: The discovery of the antiinflammatory corticosteroid drugs prednisone, prednisolone, and betamethasone, all of which, more than 30 years after their introduction, continue to enjoy wide use in human and animal medical practice throughout the world.

TL;DR: A highly specific and sensitive enzyme-linked immunosorbent assay, using a heterologous combination of antiserum raised against testosterone-3-(O-carboxymethyl) oxime-bovine serum albumin and penicillinase-labeled testosterone-11 beta-car boxymethyl ether, was developed for measuring testosterone in human plasma.

TL;DR: The sulfonate analogs showed polarity similar to that of taurine-conjugated bile acids on thin-layer chromatography, and the carbon 13 nuclear magnetic resonance spectral data for the sulfonates were tabulated.

TL;DR: The ability of testosterone to displace the hapten-enzyme conjugate and the specificity of the assay appear to depend on the position of the enzyme label on the steroid molecule as well as on the availability of antigenic sites in particular combinations of antibody and haptens-en enzyme conjugates.

TL;DR: The buffered hydrolyses of these sulfates provided the 17-epimers of the original steroids and 17,17-dimethyl-18-nor-13(14)-ene steroids, presumably via the 17 -carbocations.

TL;DR: Investigation of how 17 beta-estradiol (E2) and progesterone affect cortisol secretion in orchidectomized male rhesus macaques found that the levels and the sequence of these hormones mimicked those that occur during the menstrual cycle of intact female macaques.

TL;DR: In this article, two new 9,11secosterol, 9, 11-seco-3 beta,6 alpha,11-trihydroxy-24- methylene-5 alpha-cholest-7-en-9-one structures have been identified from the marine sponge Spongia officinalis and their structures elucidated by analysis of spectral data.

TL;DR: It is demonstrated that bovine adrenal cells can use human low-density lipoprotein (hHDL) as a source of cholesterol for steroid hormone production, and may be of particular importance when one considers that in vivo, the bHDL content ofbovine serum greatly surpasses the level of bLDL.

TL;DR: It is likely that, while soluble receptor cannot recognize the complex steroid-SBP, membrane-bound receptor can interact both with "unliganded" SBP and with the estradiol- SBP complex (but not with androgen-SBp complexes) in an estrogen-dependent tissue like human endometrium.

TL;DR: In this paper, the steroid fatty acid ester-synthesizing activity was investigated in rat brain microsomes, and a high level of synthetic activity was found in the brain of 1-to 3-week-old male rats, which rapidly decreased with aging.

TL;DR: Time-series analysis was applied to the urinary total estrogen data from 142 ovulatory menstrual cycles to determine the first statistically significant increase as a marker for the beginning of the potentially fertile phase.

TL;DR: The search for antitumor compounds from Southeast Asian plants led to ponasterones, the first phytoecdysteroids, just a year after structure determination of ecdysone and 20-hydroxyecdysone, and these findings greatly facilitated research in insect and crustacean physiology.

TL;DR: Three hapten-carrier conjugates having different lengths of bridges at the C-3 position were prepared from 25-hydroxyvitamin D3 by coupling with bovine serum albumin using the active ester method, indicating that some of these antisera are suitable for enzyme immunoassay.

TL;DR: The HPLC systems reported here are also useful in identifying the chromium trioxide oxidized products of metabolites, such as triols and tetrols, which considerably narrows down the number of probable metabolites.

TL;DR: Results suggest that DHEA treatment does not exert its effects on cellular metabolism through a receptor-mediated mechanism like other steroid hormones or by interfering in the expression of steroid hormones such as estrone and corticosterone.

TL;DR: The history of polycyclic chemistry is traced, via personal recollections, from Leopold Ruzicka's early work in characterizing terpenes to the tremendous progress in producing corticoids and estrogens from Mexican yam sterols.