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JournalISSN: 0039-7881

Synthesis 

Thieme Medical Publishers (Germany)
About: Synthesis is an academic journal published by Thieme Medical Publishers (Germany). The journal publishes majorly in the area(s): Aryl & Catalysis. It has an ISSN identifier of 0039-7881. Over the lifetime, 19935 publications have been published receiving 339064 citations. The journal is also known as: Synthesis. Special issue (Stuttgart. Print) & Synthesis (Stuttgart. Print).


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Journal ArticleDOI
TL;DR: In this article, a reagent formed by combining diethyl azodicarboxylate (DEAD) and triphenylphosphine (TPP) could be utilized in the intermolecular dehydration between an alcohol and various acidic components such as carboxylic acids, phosphoric diesters, imides, and active methylene compounds.
Abstract: The reagent formed by combining diethyl azodicarboxylate (DEAD) and triphenylphosphine (TPP) could be utilized in the intermolecular dehydration between an alcohol and various acidic components such as carboxylic acids, phosphoric diesters, imides, and active methylene compounds. By the use of DEAD and TPP, diols and hydroxy acids gave cyclic ethers and lactones, respectively. The reaction of nucleosides with DEAD and TPP afforded triphenylphosphoranylnucleosides. Alcohols reacted with 2,6-di-t-butyl-4-nitrophenol in the presence of DEAD and TPP to give aci-nitroesters which converted into the corresponding carbonyl compounds.

3,209 citations

Journal ArticleDOI
TL;DR: In this paper, a review of the oxidations of a wide range of molecules with tetrapropylammonium perruthenate including examples of both double oxidations and selective oxidations is presented.
Abstract: This article reviews the oxidations of a wide range of molecules with tetrapropylammonium perruthenate including examples of both double oxidations and selective oxidations. Mechanistic studies are discussed and general experimental procedures are reported. In addition several interesting developments in the chemistry of this reagent are outlined, that is, heteroatom oxidation, cleavage reactions and also its use in sequential reaction processes. In order to present a complete picture examples of failed reactions have been included

1,029 citations

Journal ArticleDOI
TL;DR: In this paper, a review focusing on recent achievements in the development of enantioselective transforma- tions using these axially chiral phosphoric acids and their analogues as chiral Bronsted acid catalysts is presented.
Abstract: Chiral phosphoric acids derived from axially chiral biar- yls and related chiral Bronsted acids have emerged as an attractive and widely applicable class of enantioselective organocatalysts for a variety of organic transformations. This review focuses on recent achievements in the development of enantioselective transforma- tions using these axially chiral phosphoric acids and their analogues as chiral Bronsted acid catalysts. The contents are arranged accord- ing to the specific types of carbon-carbon bond-forming reactions, followed by carbon-heteroatom bond-forming reactions and func- tional group transformations, including reduction and oxidation. Further applications to combined phosphoric acid and metal com- plex catalytic systems and new aspects in the development of chiral Bronsted acid catalysts are also highlighted.

1,016 citations

Journal ArticleDOI
TL;DR: This review highlights the advances in the literature up to May2009 in the synthesis of spirocyclic indoline natural products, including bothenantioselective and diastereoselectives methods.
Abstract: This review highlights the advances in the literature up to May2009 in the synthesis of spirocyclic indoline natural products. Thefocus is on formation of the spirocyclic chiral center, including bothenantioselective and diastereoselective methods. This review issplit into two main sections, the first consisting of the formation ofspirooxindoles and their application towards oxindole alkaloids, andthe second covering asymmetric synthesis of spiroindoline naturalproducts. 1 Introduction 2 Spirooxindole Alkaloids 2.1 Oxidative Rearrangements 2.2 Azomethine Ylide Cycloaddition 2.3 Asymmetric Addition-Elimination 2.4 Palladium-Catalyzed Heck Reactions 2.5 Palladium-Catalyzed Allylic Alkylation 2.6 Ring Expansion 2.7 Mannich Reaction 3 Spiroindoline Alkaloids 3.1 Palladium Catalyzed Asymmetric Allylic Alkylation 3.2 [4+2] Cycloaddition 3.3 Oxidative Rearrangement 3.4 Diastereoselective Pummerer Rearrangement 3.5 Tandem Iminium Cascade 3.6 Fischer Indole Synthesis 3.6.1 Diastereoselective Ring-Closing Metathesis 3.6.2 Diastereoselective Alkylation of Chiral Lactams 3.6.3 Regioselective Schmidt Reaction 3.6.4 Diastereoselective Ketene Lactonization 3.6.5 Harley-Mason Reaction 3.6.6 S N 2-Type Indole Alkylation 3.6.7 Aza-Cope-Mannich Rearrangement 4 Conclusion

937 citations

Performance
Metrics
No. of papers from the Journal in previous years
YearPapers
2023146
2022253
2021533
2020374
2019459
2018402