Showing papers in "Synthesis in 1989"
TL;DR: In this paper, the reactions sonochimiques des composes organiques et organometalliques are discussed, and a general survey of the reactions to sonochimi is presented.
Abstract: Article general sur les reactions sonochimiques des composes organiques et organometalliques
192 citations
TL;DR: A demonstration du large champ d'application and de la grande polyvalence de la reaction de Reformatsky dans de nombreuses reactions inter-and intramoleculaires faisant intervenir divers electrophiles.
Abstract: Demonstration du large champ d'application et de la grande polyvalence de la reaction de Reformatsky dans de nombreuses reactions inter- et intramoleculaires faisant intervenir divers electrophiles
186 citations
TL;DR: In this article, Nitriles 1 were efficiently transformed into N-unsubstituted amides 2 at 20 o C in 5-30 mins in good yield and with high selectivity, using basic 30% hydrogen peroxide in dimethyl sulfoxide.
Abstract: Nitriles 1 are efficiently transformed into N-unsubstituted amides 2 at 20 o C in 5-30 mins in good yield and with high selectivity, using basic 30% hydrogen peroxide in dimethyl sulfoxide
144 citations
134 citations
TL;DR: A review of low-valent titanium reagents and their development as reagents for inter-and intramolccular coupling, reductive elimination and alkylidenation is given in this article.
Abstract: The number and variety of applications of low-valent titanium reagents has expanded greatly since their initial use in 1973. This review examines the preparation of low-valent titanium reagents and their development as reagents for inter- and intramolccular coupling, reductive elimination and alkylidenation, with reference to aspects of the mechanism and stereoselectivity. 1. Introduction 2. Low-Valent Titanium Reagents 2.1. Preparation 2.2. Mechanism and Stereoselectivity 3. Intermolecular Coupling of Aldehydes and Ketones 3.1. Preparation of Alkenes 3.1.1. Preparation of Strained Ethylenes 3.1.2. Preparation of Aromatic Olefins 3.1.3. Mixed Coupling of Carbonyl Groups 3.1.4. Scope and Limitation of the Coupling Reaction 3.1.5. Selective Coupling of Ketones and Aldehydes 3.1.5.1. Groups with Large Reduction Potentials 3.1.5.2. Groups with Low Reduction Potentials 3.2. Preparation of Glycols 3.2.1. Mixed Coupling of Carbonyl Compounds 4. Intramolecular Couplings of Carbonyl Groups 4.1. Preparation of Cycloalkenes and Cyclic Ketones 4.2. Preparation of Cyclic Diols 5. Reductive Eliminations 5.1. Dcoxygenation of Glycols 5.2. Reductive Eliminations of Other Groups 6. Alkylidenation of Carbonyl Groups 6.1. Methylenations 6.2. Alkylidenations 7. Conclusions and Summary
130 citations
TL;DR: In this article, the authors present des differentes methodes de synthese des acylsilanes, de leur reactivite, and des reactifs de synthetes potentiellement interessants par exemple for l'acylation nucleophile.
Abstract: Presentation des differentes methodes de synthese des acylsilanes, de leur reactivite. Ce sont des reactifs de synthese potentiellement interessants par exemple pour l'acylation nucleophile. Plusieurs applications sont presentees dont la preparation de plusieurs pheromones et d'une sila-vitamine A
106 citations
104 citations
TL;DR: A CONVENIENT METHOD for the GENERATION of NITRILE OXIDE and its application to the SYNTHESIS of 2-ISOXAZOLINES is described in this article.
Abstract: (1992). A CONVENIENT METHOD FOR THE GENERATION OF NITRILE OXIDE AND ITS APPLICATION TO THE SYNTHESIS OF 2-ISOXAZOLINES. Organic Preparations and Procedures International: Vol. 24, No. 1, pp. 91-93.
100 citations
TL;DR: In this article, a simple and efficient two-step procedure for the preparation of triformylmethane from bromoacetic acid and dimethylformamide is presented.
Abstract: In this paper we present a simple and efficient two-step procedure for the preparation of triformylmethane from bromoacetic acid and dimethylformamide, synthesis of some triformylmethane derivatives of preparative importance, evidence for an intramolecular hydrogen bond in triformylmethane, based on its 1 H-NMR spectra measured in deuterochloroform in the presence of trichloroacetyl isocyanate, and comments on some recent erroneous statements concerning the IR spectra of triformylmethane
94 citations
TL;DR: Synthese des composes du titre par cycloaddition d'acides aryloxy acetiques ou de leurs chlorures avec des methylthio-4 benzooxazines-1,3 ou -dihydro- 1,2 quinazolines as discussed by the authors.
Abstract: Synthese des composes du titre par cycloaddition d'acides aryloxy acetiques ou de leurs chlorures avec des methylthio-4 benzooxazines-1,3 ou -dihydro-1,2 quinazolines
TL;DR: A series of 3-alkyl-4-aminobutanoic acids were prepared via the Michael addition of nitromethane to 2-alkenoic esters, followed by catalytic hydrogenation of the resultant 3-(nitromethyl)alkanoic Esters using 10% palladium on carbon in acetic acid, and acid hydrolysis of the reduction products as mentioned in this paper.
Abstract: A series of 3-alkyl-4-aminobutanoic acids were prepared via the Michael addition of nitromethane to 2-alkenoic esters, followed by catalytic hydrogenation of the resultant 3-(nitromethyl)alkanoic esters using 10% palladium on carbon in acetic acid, and acid hydrolysis of the reduction products
TL;DR: In this article, a simple synthesis of both (R)- and (S)-GABOB (5) is reported, in which doubly deprotonated (R) or (S) 2-hydroxy-1.2.
Abstract: A simple synthesis of both (R)- and (S)-GABOB (5) is reported. In the key step, doubly deprotonated (R)- or (S)-2-Hydroxy-1.2.2-triphenylethyl acetate (HYTRA) (1) is added to Cbz-protected glycinal (2)
TL;DR: Ammonium formate catalytic transfer hydrogenation in the presence of 10 % palladium on carbon has shown utility for mild and excellent deoxygenation of heteroaromatic N-oxides in neutral medium.
Abstract: Ammonium formate catalytic transfer hydrogenation in the presence of 10 % palladium on carbon has shown utility for mild and excellent deoxygenation of heteroaromatic N-oxides in neutral medium
TL;DR: The lithiated SAMP-hydrazone (S)-[(S)-1-(2,2-dimethyl-1,3-dioxan-5-ylideneamino)-2-methoxymethylpyrrolidine] is used as a chiral 1,3dihydroxyacetone-enolate equivalent in overall enantioselective α-alkylations leading to 4-ALKyl-2.5-ones (S) in good overall chemical yields and of high enantiomeric purity.
Abstract: The lithiated SAMP-hydrazone (S)-[(S)-1-(2,2-dimethyl-1,3-dioxan-5-ylideneamino)-2-methoxymethylpyrrolidine] is used as a chiral 1,3-dihydroxyacetone-enolate equivalent in overall enantioselective α-alkylations leading to 4-alkyl-2,2-dimethyl-1,3-dioxan-5-ones (S) in good overall chemical yields and of high enantiomeric purity (ee=88−≥93%)