Showing papers in "Tetrahedron in 2003"

TL;DR: Pestalotiopsis microspora, an endophytic fungus native to the rainforest of Papua New Guinea, produces a 1,3-dihydro isobenzofuran that is 1,5,7-trisubstituted and exhibits moderate antifungal properties and antioxidant activity 11 times greater than the vitamin E derivative trolox.

TL;DR: The global electrophilicity power of a series of dipoles and dipolarophiles commonly used in 1,3-dipolar cycloadditions may be conveniently classified within a unique relative scale.

TL;DR: In this article, several Knoevenagel condensations of solid or liquid aromatic aldehydes are performed with four barbituric acids, Meldrum's acid, dimedone, cyanoacetamide, malodinitrile and methyl cyano-acetate.

TL;DR: A general preparation of 2-substituted indoles starting from functionalized 2-alkynylanilines has been developed and this base mediated reaction has been used to synthesize the heterocyclic core of the marine alkaloid hinckdentine A.

TL;DR: Flow calorimetry demonstrated that the dendrimers were able to release their hydrophobic guests when in contact with a biological cell and the resulting complexes could be considered as potential drug delivery systems.

TL;DR: Foubelo et al. as mentioned in this paper studied carbanions, organolithium compounds, and dithioacetal moiety in the tetrahedron of the Tetrarch.

TL;DR: The combination of compound library synthesis and high-throughput screening has become a powerful tool in today's drug discovery effort as mentioned in this paper, however, implementation of traditionalsolution-phase reactions in library synthesis, however, is hampered by the time-consuming step of product purification.

TL;DR: This work describes the syntheses of a new poly(amidoamine) (PAMAM) dendrimer family possessing a disulfide function (cystamine) in its core, which has broad implications for the systematic size, shape and regio-chemical control of a wide range of dendritic nanostructures, many of which may be designed to mimic the sizes, shapes and Regio specific chemo-domains observed for globular proteins.

TL;DR: Xanthene derivatives were synthesized and evaluated for their potential as trypanothione reductase (TryR) inhibitors and chloroquine (CQ) potentiating agents and one compound also displaying strong intrinsic antimalarial activity.

TL;DR: In this article, the stability of a set of 105 five-membered π-electron systems (involving aromatic, nonaromatic and anti-aromatic species) was evaluated using six isodesmic reactions of which two belong to the subclass of homodesmotic reactions, which are based on cyclic and acyclic reference systems.

TL;DR: In this article, the authors revisited the old chemistry between CO 2 and primary alkylamines and showed that CO 2 entrapment can be prevented by using carbamic acids.

TL;DR: Biological systems have evolved haloperoxidase (HaloPO) enzymes to catalyze the oxidation of chloride, bromide and iodide by hydrogenperoxide by hydrogen peroxide.

TL;DR: In the presence of Pd(OAc) 2 and a bulky phosphine ligand using Cs 2 CO 3 as base 2-Phenyl-5-thiazolecarboxanilide undergoes successive diarylation at the 4 and 5 positions accompanied by decarbamoylation as discussed by the authors.

TL;DR: In this article, task-specific ionic liquid was used as synthetic equivalent of ILSP matrices for the preparation of a small library of 4-thiazolidinones, which was functionalized with 4-(formylphenoxy)butyric acid by using usual esterification reaction conditions (DCC/DMAP as catalyst).